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1. 发明申请

WO2007109157A3 SOLVENT DELIVERY SYSTEM FOR LIQUID CHROMATOGRAPHY THAT MAINTAINS FLUID INTEGRITY AND PRE-FORMS GRADIENTS 审中-公开
公开(公告)号：WO2007109157A3
公开(公告)日：2007-09-27
申请号：PCT/US2007/006679
申请日：2007-03-16
申请人： WATERS INVESTMENTS LIMITED , CIAVARINI, Steven, J. , PENSAK, Stanley, P. , FINCH, Jeffrey, W. , FADGEN, Keith , LIU, Hongji
发明人： CIAVARINI, Steven, J. , PENSAK, Stanley, P. , FINCH, Jeffrey, W. , FADGEN, Keith , LIU, Hongji
IPC分类号： B01D15/08
摘要： A solvent delivery subsystem (720) for a chromatographic device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery to the separation column. The mixing of the gradient is independent and does not interfere with the gradient delivery. To form the gradient, the outputs of an aqueous pump (715A) and an organic pump (715B) are mixed to fill a storage capillary (722) while a downstream point from the storage capillary (722) is vented to atmosphere. After the gradient formation, the vent to atmosphere is closed, the solvent delivery system rises to high pressure, and only aqueous pump (715A) runs for gradient delivery. To maintain integrity of the fluid stream, the solvent delivery system used feed forward compensation and controls at least one parameter selected from the group consisting of pressure and flow in the conduit means to follow a gradual ramp.

2. 发明申请

WO2005071396A1 A SAMPLE INJECTOR SYSTEM FOR LIQUID CHROMATOGRAPHY 审中-公开
标题翻译：用于液相色谱的样品注射器系统
公开(公告)号：WO2005071396A1
公开(公告)日：2005-08-04
申请号：PCT/US2005/002401
申请日：2005-01-18
申请人： WATERS INVESTMENTS LIMITED , GERHARDT, Geoff, C. , JORGENSON, James, W. , FADGEN, Keith
发明人： GERHARDT, Geoff, C. , JORGENSON, James, W. , FADGEN, Keith
IPC分类号： G01N30/16
CPC分类号： G01N30/22 , G01N30/36 , G01N2030/385 , Y10T436/2575
摘要： An injection device (10) includes a carrier inlet (40), a sample inlet (46), waste outlet (44) and a chamber outlet (64) attached to separation column (66). Valves (52, 54, 56) are used to control flow such that sample flows into chamber (22) and is carried into the chamber outlet (42).
摘要翻译：注射装置（10）包括载体入口（40），样品入口（46），废物出口（44）和连接到分离塔（66）的室出口（64）。阀（52,54,56）用于控制流动，使得样品流入室（22）并被运送到室出口（42）中。

3. 发明申请

WO2007109529A3 DEVICE AND METHODS FOR REDUCING PRESSURE AND FLOW PERTURBATIONS IN A CHROMATOGRAPHIC SYSTEM 审中-公开
公开(公告)号：WO2007109529A3
公开(公告)日：2007-09-27
申请号：PCT/US2007/064152
申请日：2007-03-16
申请人： WATERS INVESTMENTS LIMITED , FADGEN, Keith , USOWICZ, James, E. , SOARES, Miguel
发明人： FADGEN, Keith , USOWICZ, James, E. , SOARES, Miguel
IPC分类号： G01N30/02
摘要： Embodiments of the present invention are directed to methods and apparatus for placing a sample in a chromatographic system. The device and method feature placing samples held in a sample loop to pressurization prior to placing such sample loop in communication with high pressure conduits.

4. 发明申请

WO2007022236A2 METHODS, COMPOSITIONS AND DEVICES FOR PERFORMING IONIZATION DESORPTION ON SILICON DERIVATIVES 审中-公开
标题翻译：用于对硅衍生物进行离子沉淀的方法，组合物和装置
公开(公告)号：WO2007022236A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/031932
申请日：2006-08-16
申请人： WATERS INVESTMENTS LIMITED , BOVIER, Edouard, S., P. , DELLAROVERE, Dennis , BENEVIDES, Christopher, C. , FADGEN, Keith
发明人： BOVIER, Edouard, S., P. , DELLAROVERE, Dennis , BENEVIDES, Christopher, C. , FADGEN, Keith
IPC分类号： C12M3/00
CPC分类号： H01J49/04 , B01L3/5085 , Y10T436/24
摘要： A device for the presentation of samples for MALDI or DIOS ion source, comprising a semiconductor wafer body having at least one first surface and at least one second surface, the first surface being chemically modified to repel said aqueous sample toward said second surface.
摘要翻译：用于呈现用于MALDI或DIOS离子源的样品的装置，包括具有至少一个第一表面和至少一个第二表面的半导体晶片体，所述第一表面经化学修饰以将所述水性样品排斥到所述第二表面。

5. 发明申请

WO2005053813A1 FLOW SENSING APPARATUS 审中-公开
标题翻译：流量感应装置
公开(公告)号：WO2005053813A1
公开(公告)日：2005-06-16
申请号：PCT/US2004/039415
申请日：2004-11-23
申请人： WATERS INVESTMENTS LIMITED , GERHARDT, Geoff, C. , LUONGO, Joseph, A. , FADGEN, Keith
发明人： GERHARDT, Geoff, C. , LUONGO, Joseph, A. , FADGEN, Keith
IPC分类号： B01D15/08
CPC分类号： G01F1/68 , G01F1/363 , G01N30/10 , G01N30/30 , G01N30/32 , G01N2030/324 , G01N2030/326 , G05D11/132
摘要： A method and apparatus for monitoring and controlling the nano-scale flow rate of fluid in the operating flow path of a HPLC system. A first flow sensor is disposed in a first flow path between a first flow-divider and a fluidic tee. A second flow sensor is disposed in a second flow path between a second flow-divider and the fluidic tee. A first recycle flow restrictor is disposed in the first recycle flow path in fluid communication with the first flow-divider. A second recycle flow restrictor is disposed in the second. The permeability of each recycle flow restrictor can be selected to produce a desired flow rate with each respective flow path. The output signals of the first and second flow sensors to control output of a pump within each flow path.
摘要翻译：一种用于监测和控制HPLC系统的操作流路中的流体的纳米流量的方法和装置。第一流量传感器设置在第一分流器和流体三通之间的第一流动路径中。第二流量传感器设置在第二分流器和流体三通之间的第二流动路径中。第一再循环流量限制器设置在与第一分流器流体连通的第一再循环流动路径中。第二个再循环流量限制器设置在第二个再循环流量限制器中。可以选择每个再循环流量限制器的渗透性，以产生每个相应流动路径的期望流量。第一和第二流量传感器的输出信号以控制每个流动路径内的泵的输出。

6. 发明申请

WO2019171151A1 MODULAR EXTRACTION VESSEL AND ASSOCIATED METHODS 审中-公开
公开(公告)号：WO2019171151A1
公开(公告)日：2019-09-12
申请号：PCT/IB2018/051530
申请日：2018-03-08
申请人： WATERS TECHNOLOGIES CORPORATION , FOGWILL, Michael O. , FADGEN, Keith , KELLEY, Scott , MICHIENZI, Joseph D.
发明人： FOGWILL, Michael O. , FADGEN, Keith , KELLEY, Scott , MICHIENZI, Joseph D.
IPC分类号： B01D11/02
摘要： Exemplary embodiments are directed to a method for diffusing fluid flow within a modular extraction vessel. A modular extraction vessel can be assembled using a plurality of extraction vessel chambers, and each extraction vessel chamber is associated with at least one diffuser element. An extracting solvent is introduced into the modular extraction vessel, and the extracting solvent flows through the extraction vessel chambers. By flowing through the extraction vessel chambers and diffusers, the flow path of the extracting solvent is diffused along an extraction path.

7. 发明申请

WO2013032832A1 CHROMATOGRAPHY COLUMN ASSEMBLY 审中-公开
标题翻译：色谱柱组装
公开(公告)号：WO2013032832A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/051972
申请日：2012-08-23
申请人： WATERS TECHNOLOGIES CORPORATION , MICHIENZI, Joseph D. , FADGEN, Keith , LEVEILLE, SR., Wade P. , FISK, Raymond P. , MARZALKOWSKI, JR., Frank John
发明人： MICHIENZI, Joseph D. , FADGEN, Keith , LEVEILLE, SR., Wade P. , FISK, Raymond P. , MARZALKOWSKI, JR., Frank John
IPC分类号： B01D15/08 , B23P19/00
CPC分类号： B05B5/16 , B01D15/10 , B01D15/1871 , B01D15/22 , G01N30/60 , G01N30/6004 , G01N30/6026 , G01N30/603 , G01N30/6039 , G01N30/6052 , G01N30/6095 , G01N30/7266 , Y10T29/49908
摘要： Described is a chromatography column assembly that includes a permanently deformable outer tube, an intermediate tube, an inner tube and a sorbent bed disposed within the inner tube. The sorbent bed may be in the form of packed chromatographic particles or a porous monolithic structure. A radial seal is provided by one or more uniform radial crimps at longitudinal locations on the assembly. The uniform radial crimp compresses the outer tube and underlying intermediate tube onto the inner tube to achieve a high pressure liquid tight seal between the three tubes. The length and depth of each crimp is accurately formed to accommodate the requirements of the particular application. Leakage along the tubing assembly is prevented and void volume is reduced or eliminated. No external ferrule or ferrule swaging mechanism is needed; therefore the chromatography column assembly is easily adapted for use in various chromatographic column configurations.
摘要翻译：描述了一种色谱柱组件，其包括永久变形的外管，中间管，内管和设置在内管内的吸附剂床。吸附剂床可以是填充色谱颗粒或多孔整体结构的形式。在组件的纵向位置处由一个或多个均匀的径向卷曲提供径向密封。均匀的径向卷曲将外管和下面的中间管压缩到内管上，以实现三管之间的高压液密封。精确地形成每个卷曲的长度和深度以适应特定应用的要求。防止管道组件的泄漏，减少或消除空隙体积。不需要外部套圈或套圈型锻机构; 因此色谱柱组件易于适用于各种色谱柱配置。

8. 发明申请

WO2011014372A1 METHOD AND APPARATUS FOR PERFORMING MASS SPECTROMETRY 审中-公开
标题翻译：用于执行质谱分析的方法和装置
公开(公告)号：WO2011014372A1
公开(公告)日：2011-02-03
申请号：PCT/US2010/042241
申请日：2010-07-16
申请人： WATERS TECHNOLOGIES CORPORATION , FADGEN, Keith
发明人： FADGEN, Keith
IPC分类号： G01N30/72
CPC分类号： C12M45/09 , G01N30/06 , G01N30/7233 , G01N30/88 , G01N2030/067 , G01N2030/8831 , G01N2030/8881
摘要： The invention feature devices and methods for preserving and processing samples comprising a fluid having deuterated compounds. The device of the present invention comprises a housing defining a first chamber and a second chamber. The first chamber is heated to an elevated temperature and receives the sample and performs a digestion process on the sample at the elevated temperature. The second chamber is cooled to a low temperature and receives the deuterated digested sample from the first chamber and performs one or more separation steps to isolate an analyte. The device of further comprises conduit means for containing and moving the sample into the first chamber to form a digested sample. The conduit means moves the digested sample from the first chamber to the second chamber to separate the sample to form at least one analyte. The analyte is maintained at the low temperature to preserve its deuterated form.
摘要翻译：本发明的特征在于用于保存和处理包含具有氘代化合物的流体的样品的装置和方法。本发明的装置包括限定第一室和第二室的壳体。将第一室加热到升高的温度并接收样品并在高温下对样品进行消化处理。将第二室冷却至低温，并从第一室接收氘代消化的样品，并执行一个或多个分离步骤以分离分析物。该装置还包括用于容纳和移动样品进入第一室以形成消化样品的导管装置。导管装置将消化的样品从第一室移动到第二室以分离样品以形成至少一种分析物。分析物保持在低温以保持其氘化形式。

9. 发明申请

WO2009088663A1 LIQUID-CHROMATOGRAPHY CONDUIT ASSEMBLIES HAVING HIGH-PRESSURE SEALS 审中-公开
标题翻译：具有高压密封的液相色谱仪组件
公开(公告)号：WO2009088663A1
公开(公告)日：2009-07-16
申请号：PCT/US2008/086944
申请日：2008-12-16
申请人： WATERS TECHNOLOGIES CORPORATION , BENEVIDES, Christopher, C. , FADGEN, Keith , LAVALLE, Michael , JEANNOTTE, Anthony
发明人： BENEVIDES, Christopher, C. , FADGEN, Keith , LAVALLE, Michael , JEANNOTTE, Anthony
IPC分类号： B01D15/08
CPC分类号： B01D15/14 , B01D15/22 , G01N30/6004 , G01N30/6026 , G01N30/603 , G01N30/6039 , Y10T29/49826
摘要： A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits.
摘要翻译：制备液相色谱装置的方法包括将两个内导管插入中间管中，将中间管插入外管中，在中间管与至少一个内导管之间形成近端密封，并形成远端密封在中间管与至少一个内部管道之间。液相色谱装置包括外管，设置在外管中的中间管，设置在中间管中的两个内导管，中间管与至少一个内导管之间的近侧密封，以及位于中间管之间的远端密封中间管和至少一个内部管道。

10. 发明申请

WO2012151080A1 HIGH PRESSURE FLUIDIC SWITCHING VALVE HAVING VARIABLE PRESSURE LOADING 审中-公开
标题翻译：具有可变压力负载的高压液压开关阀
公开(公告)号：WO2012151080A1
公开(公告)日：2012-11-08
申请号：PCT/US2012/034760
申请日：2012-04-24
申请人： WATERS TECHNOLOGIES CORPORATION , BUNNER, Bernard , MICHIENZI, Joseph , FADGEN, Keith
发明人： BUNNER, Bernard , MICHIENZI, Joseph , FADGEN, Keith
IPC分类号： F16K31/12
CPC分类号： F16K3/10 , F16K3/18 , F16K31/041 , G01N35/1097 , G01N2030/202 , Y10T137/0318
摘要： Described are a rotary shear seal valve and a method for switching a high pressure fluid. The method includes applying a fixed force between a planar surface of a rotor and a planar surface of a stator. The planar surface of the rotor includes a fluidic channel and the planar surface of the stator has a pair of ports to receive and provide the fluid. A control signal is applied to a linear actuator coupled to the rotor to generate a controllable force between the planar surfaces of the rotor and stator. The control signal is responsive to a rotational state of the rotor. The total force between the planar surfaces of the rotor and the stator is substantially equal to a sum of the fixed force and the controllable force. The method reduces the wear and extends the lifetime of components in a rotary shear seal valve.
摘要翻译：描述了一种旋转剪切密封阀和一种用于切换高压流体的方法。该方法包括在转子的平坦表面和定子的平坦表面之间施加固定的力。转子的平面表面包括流体通道，并且定子的平坦表面具有一对接口并提供流体的端口。控制信号被施加到耦合到转子的线性致动器，以在转子和定子的平面之间产生可控的力。控制信号响应转子的旋转状态。转子和定子的平面之间的总的力基本上等于固定力和可控力之和。该方法减少了磨损并延长了旋转剪切密封阀中部件的使用寿命。

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