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1. 发明申请

WO1997015688A1 NOVEL DIAGNOSTIC MARKER FOR SPLICING VARIANTS OF GENES ASSOCIATED WITH NEUROLOGICAL FUNCTION 审中-公开
标题翻译：用于分离与神经功能相关的基因变异的新型诊断标记
公开(公告)号：WO1997015688A1
公开(公告)日：1997-05-01
申请号：PCT/US1996017128
申请日：1996-10-25
申请人： WASHINGTON UNIVERSITY SCHOOL OF MEDICINE , UNIVERSITY OF SOUTH FLORIDA , HARDY, John, A. , GOATE, Alison, M.
发明人： WASHINGTON UNIVERSITY SCHOOL OF MEDICINE , UNIVERSITY OF SOUTH FLORIDA
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Methods are described for detecting the presence or absence of a four amino acid motif (VRXQ) in expressed proteins that arise from aberrant alternative splicing of pre-mRNA in genes associated with normal neurological function. The presence of these variants suggest that mutational events in these genes have occurred. Nucleotide sequences and nitron-exon junctional sequences of examples of this splicing variant are provided.
摘要翻译：描述了用于检测在与正常神经功能相关的基因中的前mRNA的异常选择性剪接产生的表达蛋白中存在或不存在四个氨基酸基序（VRXQ）的方法。这些变体的存在表明这些基因中的突变事件已经发生。提供了这种剪接变体实例的核苷酸序列和硝酮 - 外显子连接序列。

2. 发明申请

WO1997015689A1 METHOD TO DETECT POLYMORPHISM IN THE S182 GENE 审中-公开
标题翻译：检测S182基因多态性的方法
公开(公告)号：WO1997015689A1
公开(公告)日：1997-05-01
申请号：PCT/US1996017132
申请日：1996-10-25
申请人： WASHINGTON UNIVERSITY SCHOOL OF MEDICINE , UNIVERSITY OF SOUTH FLORIDA , HARDY, John, A. , GOATE, Alison, M.
发明人： WASHINGTON UNIVERSITY SCHOOL OF MEDICINE , UNIVERSITY OF SOUTH FLORIDA
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6883 , C12Q1/683 , C12Q1/6869 , C12Q2600/156
摘要： A method of detecting polymorphisms in the S182 gene by detecting mutations in the S182 gene using selected mismatched PCR primers comprising sequences derived from intronic sequences of the S182 gene is provided. A method of identifying an individual susceptible to late onset Alzheimer's Disease is also provided.
摘要翻译：提供了通过使用包含来自S182基因的内含子序列的序列的选择的错配PCR引物检测S182基因中的突变来检测S182基因中的多态性的方法。还提供了鉴定易患迟发性阿尔茨海默病的个体的方法。

3. 发明申请

WO1997003999A1 MUTANT S182 GENES 审中-公开
标题翻译： MUTANT S182基因
公开(公告)号：WO1997003999A1
公开(公告)日：1997-02-06
申请号：PCT/US1996011065
申请日：1996-06-26
申请人： WASHINGTON UNIVERSITY SCHOOL OF MEDICINE , UNIVERSITY OF SOUTH FLORIDA , GOATE, Alison, M. , HARDY, John, A.
发明人： WASHINGTON UNIVERSITY SCHOOL OF MEDICINE , UNIVERSITY OF SOUTH FLORIDA
IPC分类号： C07H21/04
CPC分类号： C12Q1/6883 , A01K2217/05 , C07K14/4711 , C12Q2600/156
摘要： The invention provides novel mutant S182 sequences, methods of diagnosing Alzheimer's disease using these novel mutant S182 genes, a model system for Alzheimer's disease comprising a mutant S182 gene, and methods of identifying mutations in genes homologous to the S182 gene.
摘要翻译：本发明提供了新的突变S182序列，使用这些新型突变体S182基因诊断阿尔茨海默病的方法，包含突变S182基因的阿尔茨海默病模型系统，以及鉴定与S182基因同源的基因突变的方法。

4. 发明申请

WO1994006828A1 PEPTIDES TOLERIZING T-CELLS AND COMPOSITIONS THEREOF 审中-公开
标题翻译： PEPTIDES TOLERIZING T-CELLS AND COMPOSITIONS WITHEROF
公开(公告)号：WO1994006828A1
公开(公告)日：1994-03-31
申请号：PCT/US1993008456
申请日：1993-09-09
申请人： WASHINGTON UNIVERSITY SCHOOL OF MEDICINE
发明人： WASHINGTON UNIVERSITY SCHOOL OF MEDICINE , ALLEN, Paul, M. , SLOAN-LANCASTER, Joanne , EVAVOLD, Brian, D.
IPC分类号： C07K15/00
CPC分类号： A61K38/1709 , A61K2039/5154 , C07K14/805
摘要： The present invention provides a tolerizing peptide and a therapeutic composition containing at least one such tolerizing peptide which when administered to an individual in a therapeutically effective amount is capable of tolerizing at least a portion and preferably all of the T cells of said individual which are specific for an antigen (e.g. an allergen, an autoantigen or a transplantation antigen), said tolerizing peptide having the ability to combine with MHC proteins on antigen presenting cells (APC) and cause binding of T cell receptors on at least a portion of the T cells of an individual to said peptide-MHC complex. Said tolerizing peptide preferably has the ability to cause no detectable or minimal proliferation of at least a portion of the T cells of an individual which are specific for said antigen when said peptide is administered in vivo in immunogenic form. The invention also provides a method for treating sensitivity to a particular antigen in an individual and a method for tolerizing at least a portion of a population of T cells in an individual which are specific for an antigen.
摘要翻译：本发明提供了一种耐受性肽和含有至少一种这样的耐受性肽的治疗组合物，其当以治疗有效量施用于个体时能够耐受所述个体的至少一部分，优选全部T细胞，其特异性对于抗原（例如变应原，自身抗原或移植抗原），所述耐受肽具有与抗原呈递细胞（APC）上的MHC蛋白结合的能力，并引起T细胞受体在至少一部分T细胞上的结合的个体对所述肽-MHC复合物。当所述肽以免疫原性形式在体内施用时，所述耐受肽优选具有引起对所述抗原特异性的个体的至少一部分T细胞的可检测或最小增殖的能力。本发明还提供了治疗对个体中特定抗原的敏感性的方法和用于耐受个体中对抗原特异性的至少一部分T细胞群的方法。

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