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1. 发明申请

WO2017017631A2 ANTIBACTERIAL THERAPEUTICS AND PROPHYLACTICS 审中-公开
标题翻译：抗菌治疗药物及预防措施
公开(公告)号：WO2017017631A2
公开(公告)日：2017-02-02
申请号：PCT/IB2016/054506
申请日：2016-07-28
申请人： VYOME BIOSCIENCES PVT. LTD.
发明人： SENGUPTA, Shiladitya , GHOSH, Shamik , GHOSH, Sumana , SINHA, Mau , SADHASIVAM, Suresh , BHATTACHARYYA, Anamika , MAVUDURU, Siva Ganesh , TANDON, Nupur , KUMAR, Deepak
IPC分类号： C07D471/00
CPC分类号： C07D513/04 , C07C323/59 , C07C323/60 , C07D215/56 , C07D239/96 , C07D263/38 , C07D311/22 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/00 , C07D487/04
摘要： The present disclosure relates generally to novel molecules, compositions, and formulations for treatment of bacterial infections in general and more specifically to bacterial infections with antibiotic resistant pathogens.
摘要翻译：本公开一般涉及一般用于治疗细菌感染的新型分子，组合物和制剂，更具体地涉及抗生素抗性病原体的细菌感染。

2. 发明申请

WO2017216722A3 SYNERGISTIC ANTIFUNGAL COMPOSITIONS AND METHODS THEREOF 审中-公开
公开(公告)号：WO2017216722A3
公开(公告)日：2017-12-21
申请号：PCT/IB2017/053505
申请日：2017-06-13
申请人： VYOME BIOSCIENCES PVT. LTD.
发明人： GHOSH, Shamik , GHOSH, Sumana , SINHA, Mau , SADHASIVAM, Suresh , JAIN, Anubhuti , BHATTACHARYYA, Anamika
IPC分类号： A61K31/122 , A61K31/137 , A61K31/19 , A61K31/20 , A61K31/201 , A61K31/343 , A61K31/407 , A61K31/4164 , A61K31/4174 , A61K31/4178 , A61K31/4196 , A61K31/422 , A61K31/496 , A61K31/506 , A61K31/513
摘要： The present invention relates to the field of antimicrobials and pharmaceutical sciences. The invention provides antifungal compositions for the management of fungal growth and treatment of fungal infections, including treatment of resistant fungal infections. The present compositions comprise at least one antifungal agent and at least one medium-chain saturated or unsaturated fatty acid having carbon chain length of C-1 to C-14 or ester thereof, optionally along with excipient(s), giving rise to a synergistic antifungal activity.

3. 发明申请

WO2017216722A2 SYNERGISTIC ANTIFUNGAL COMPOSITIONS AND METHODS THEREOF 审中-公开
标题翻译：协同抗真菌组合物及其方法
公开(公告)号：WO2017216722A2
公开(公告)日：2017-12-21
申请号：PCT/IB2017/053505
申请日：2017-06-13
申请人： VYOME BIOSCIENCES PVT. LTD.
发明人： GHOSH, Shamik , GHOSH, Sumana , SINHA, Mau , SADHASIVAM, Suresh , JAIN, Anubhuti , BHATTACHARYYA, Anamika
IPC分类号： A61K31/122
CPC分类号： A61K31/19 , A61K31/122 , A61K31/137 , A61K31/20 , A61K31/201 , A61K31/23 , A61K31/231 , A61K31/343 , A61K31/407 , A61K31/4164 , A61K31/4174 , A61K31/4178 , A61K31/4196 , A61K31/422 , A61K31/496 , A61K31/506 , A61K31/513 , A61K31/5375 , A61K31/69 , A61K31/7032 , A61K31/7034 , A61K2300/00
摘要： The present invention relates to the field of antimicrobials and pharmaceutical sciences. The invention provides antifungal compositions for the management of fungal growth and treatment of fungal infections, including treatment of resistant fungal infections. The present compositions comprise at least one antifungal agent and at least one medium-chain saturated or unsaturated fatty acid having carbon chain length of C-1 to C-14 or ester thereof, optionally along with excipient(s), giving rise to a synergistic antifungal activity.
摘要翻译：本发明涉及抗微生物剂和药物科学领域。本发明提供了用于控制真菌生长和治疗真菌感染的抗真菌组合物，包括治疗抗性真菌感染。本发明组合物包含至少一种抗真菌剂和至少一种碳链长度为C-1至C-14的中链饱和或不饱和脂肪酸或其酯，任选与赋形剂一起，产生协同作用抗真菌活性。

4. 发明申请

WO2018042367A3 COMPOUNDS, COMPOSITONS AND METHODS RELATED TO ANTIMICROBIAL APPLICATIONS 审中-公开
标题翻译：与微生物应用有关的化合物，复合物和方法
公开(公告)号：WO2018042367A3
公开(公告)日：2018-03-08
申请号：PCT/IB2017/055245
申请日：2017-08-31
申请人： VYOME BIOSCIENCES PVT. LTD.
发明人： GHOSH, Sumana , SINHA, Mau , BHATTACHARYYA, Anamika , SADHASIVAM, Suresh , GHOSH, Shamik , SAMANTA, Ritwik , TANDON, Nupur
IPC分类号： C08G73/02 , C08G63/00 , C08G18/00
摘要： The present disclosure is in the field of polymers and pharmaceuticals/antimicrobials. The disclosure provides compounds based on SNAP (synthetic novel antimicrobial polymer) technology, compositions and methods of managing microbial infections including surgical site infections (SSIs). The present compounds are used as a management/therapeutic strategy to target microbial infections and have advantages including excellent antimicrobial potency, biofilm disruption ability, broad spectrum activity against various organisms covering both gram negative and gram positive bacteria as well as fungal pathogens, and low toxicity profile to ensure a healthy therapeutic window for use in humans.
摘要翻译：本公开涉及聚合物和药物/抗微生物剂领域。本公开提供基于SNAP（合成新型抗微生物聚合物）技术的化合物，控制包括手术部位感染（SSI）的微生物感染的组合物和方法。本发明化合物被用作针对微生物感染的管理/治疗策略，并且具有优势，包括优异的抗微生物效力，生物膜破裂能力，针对覆盖革兰氏阴性和革兰氏阳性细菌的各种生物以及真菌病原体的广谱活性，以及低毒性以确保用于人类的健康治疗窗口。

5. 发明申请

WO2015114666A2 TREATMENTS FOR RESISTANT ACNE 审中-公开
标题翻译：抗性ACNE治疗
公开(公告)号：WO2015114666A2
公开(公告)日：2015-08-06
申请号：PCT/IN2015/000057
申请日：2015-01-29
申请人： VYOME BIOSCIENCES PVT. LTD.
发明人： SENGUPTA, Shiladitya , CHAWRAI, Suresh Rameshlal , GHOSH, Shamik , GHOSH, Sumana , JAIN, Nilu , SADHASIVAM, Suresh , BUCHTA, Richard , BHATTACHARYYA, Anamika
IPC分类号： A61K31/4709
CPC分类号： A61K31/55 , A61K9/0014 , A61K31/192 , A61K31/4709 , A61K45/06 , A61K47/02 , A61K47/08 , A61K47/10 , A61K47/183 , A61K47/32 , A61K47/36 , A61K47/38 , C07D513/04 , Y02A50/475 , Y02A50/491 , Y02A50/492 , A61K2300/00
摘要： The present disclosure relates generally to novel molecules, compositions, and formulations for treatment of bacterial infections in general and more specifically to bacterial infections with antibiotic resistant pathogens
摘要翻译：本公开一般涉及用于一般治疗细菌感染的新分子，组合物和制剂，更具体地涉及抗生素抗性病原体的细菌感染

6. 发明申请

WO2018042367A2 COMPOUNDS, COMPOSITONS AND METHODS RELATED TO ANTIMICROBIAL APPLICATIONS 审中-公开
公开(公告)号：WO2018042367A2
公开(公告)日：2018-03-08
申请号：PCT/IB2017/055245
申请日：2017-08-31
申请人： VYOME BIOSCIENCES PVT. LTD.
发明人： GHOSH, Sumana , SINHA, Mau , BHATTACHARYYA, Anamika , SADHASIVAM, Suresh , GHOSH, Shamik , SAMANTA, Ritwik , TANDON, Nupur
IPC分类号： C08G73/02 , C08G63/00 , C08G18/00
摘要： The present disclosure is in the field of polymers and pharmaceuticals/antimicrobials. The disclosure provides compounds based on SNAP (synthetic novel antimicrobial polymer) technology, compositions and methods of managing microbial infections including surgical site infections (SSIs). The present compounds are used as a management/therapeutic strategy to target microbial infections and have advantages including excellent antimicrobial potency, biofilm disruption ability, broad spectrum activity against various organisms covering both gram negative and gram positive bacteria as well as fungal pathogens, and low toxicity profile to ensure a healthy therapeutic window for use in humans.

7. 发明申请

WO2017125893A1 METHOD OF DETECTING AND TREATING P. ACNES AND KIT THEREOF 审中-公开
标题翻译：检测和治疗P.ACNES的方法及其试剂盒
公开(公告)号：WO2017125893A1
公开(公告)日：2017-07-27
申请号：PCT/IB2017/050313
申请日：2017-01-20
申请人： VYOME BIOSCIENCES PVT. LTD.
发明人： SENGUPTA, Shiladitya , GHOSH, Shamik , SINHA, Mau , SADHASIVAM, Suresh , BHATTACHARYYA, Anamika
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/106 , C12Q2600/156
摘要： The present disclosure relates to method for detecting P. acnes as well as a method for detecting mutation in genomic sequence of 23S rRNA sequence of P. acnes, particularly mutation A2058G. The method comprises amplifying a region of 23S rRNA specific for P. acnes using primers of SEQ ID Nos. 1 and 2 followed by detecting the mutation through selective action of an endonuclease at a mismatch at the site of said mutation or post-hybridization with specific P. acnes 23S regions followed by mismatch specific endonuclease action. The presence of A2058G mutation confers antibiotic resistance, particularly clindamycin and erythromycin resistance, and thus the present disclosure also relates to methods of treating acne caused by clindamycin resistant P. acnes by using fluoroquinolone based antibiotics.
摘要翻译：本发明涉及用于检测痤疮丙酸杆菌的方法以及用于检测痤疮丙酸杆菌的23S rRNA序列的基因组序列中的突变，特别是突变A2058G的突变的方法。该方法包括使用SEQ ID Nos.1和2的引物扩增痤疮丙酸杆菌特异性的23S rRNA区域，然后通过在所述突变位点处的错配或与特异性后杂交后的内切核酸酶的选择性作用检测突变痤疮丙酸杆菌23S区域，然后是错配特异性核酸内切酶作用。 A2058G突变的存在赋予抗生素抗性，特别是克林霉素和红霉素抗性，因此本公开还涉及通过使用基于氟喹诺酮的抗生素来治疗由克林霉素抗性痤疮丙酸杆菌引起的痤疮的方法。

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