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2. 发明申请

WO2004039391A1 VIRAL SERPIN REGULATION OF INFLAMATION 审中-公开
标题翻译： VIRAL SERPIN调节爆发
公开(公告)号：WO2004039391A1
公开(公告)日：2004-05-13
申请号：PCT/CA2003/001682
申请日：2003-10-31
申请人： LUCAS, Alexandra, R. , MCFADDEN, Grant, D.
发明人： LUCAS, Alexandra, R. , MCFADDEN, Grant, D.
IPC分类号： A61K38/03
CPC分类号： A61K38/55
摘要： The present invention provides for a pharmaceutical composition containing at least one compound that promotes intracellular signalling via the human urokinase plasminogen activator receptor. The compound binds the human urokinase plasminogen activator receptor, the compound binds one or more intracellular protein(s) directly or indirectly associated with intracellular signalling via human urokinase plasminogen activator receptor, and the compound binds one or more intracellular protein(s) that are modulated by urokinase plasminogen activator receptor activity. The compound is an organic or inorganic compound with a molecular weight less than 1kDa, compound is a peptide between 2 and 20 amino acids in length, and the compound is a polypeptide greater than 20 amino acids in length. The compound is an antibody or fragment thereof, the compound is a nucleic acid, and the compound is administered to humans in vivo , and to human cells ex vivo . The composition includes a pharmaceutically acceptable carrier, and the composition is administered to a human individual for the treatment of an inflamatory condition.
摘要翻译：本发明提供含有至少一种通过人尿激酶纤溶酶原激活物受体促进细胞内信号传导的化合物的药物组合物。该化合物结合人尿激酶纤溶酶原激活物受体，该化合物通过人尿激酶纤溶酶原激活物受体直接或间接地与细胞内信号传导相关联的一种或多种细胞内蛋白质，并且该化合物结合调节的一种或多种细胞内蛋白质通过尿激酶纤溶酶原激活物受体活性。该化合物是分子量小于1kDa的有机或无机化合物，化合物是长度在2至20个氨基酸之间的肽，并且化合物是长度大于20个氨基酸的多肽。化合物是抗体或其片段，化合物是核酸，并且化合物在体内施用于人体，并且离体施用于人类细胞。组合物包括药学上可接受的载体，并且将组合物施用于人个体以治疗炎症状况。

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