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1. 发明申请

WO2009143149A3 IMPROVED IMAGING OF IMMUNOMAGNETICALLY ENRICHED RARE CELLS 审中-公开
标题翻译：改善免疫细胞增殖的成熟细胞
公开(公告)号：WO2009143149A3
公开(公告)日：2010-01-14
申请号：PCT/US2009044510
申请日：2009-05-19
申请人： VERIDEX LLC , SCHOLTENS TYCHO M , SCHREUDER FREDERIK , GREVE JAN , TIBBE ARJAN , TERSTAPPEN LEON W M M
发明人： SCHOLTENS TYCHO M , SCHREUDER FREDERIK , GREVE JAN , TIBBE ARJAN , TERSTAPPEN LEON W M M
IPC分类号： B03C1/033
CPC分类号： G01N33/54326
摘要： A method for removing excess unbound ferrofluid and imaging immunomagnetically enriched circulating tumor cells is provided. A vessels having a preformed grooves in the viewing surface is optimally designed for cell alignment and imaging. After separating the unbound particles by centrifugation, an externally-applied force is applied to transport magnetically responsive particle-CTC complex toward the transparent collection wall. The grooved inner surface of the viewing face of the chamber provide uniform distribution of the particles for easy imaging. The invention is also useful in conducting quantitative analysis and sample preparation in conjunction with automated cell enumeration techniques as in quantitative analysis of CTC in disease.
摘要翻译：提供了一种去除过量未结合的铁磁流体和成像免疫磁性富集的循环肿瘤细胞的方法。在观察表面中具有预成形凹槽的容器被最佳设计用于细胞对准和成像。通过离心分离未结合的颗粒后，施加外部施加的力以将磁响应颗粒-CTC复合物输送到透明收集壁。室的观察面的带槽的内表面提供了均匀分布的颗粒以便于成像。本发明还可用于与自动细胞计数技术结合进行定量分析和样品制备，如在疾病中CTC的定量分析中。

2. 发明申请

WO2007133465A3 A LASER ILLUMINATION SYSTEM IN FLUORESCENT MICROSCOPY 审中-公开
标题翻译：荧光显微镜中的激光照射系统
公开(公告)号：WO2007133465A3
公开(公告)日：2008-09-25
申请号：PCT/US2007010727
申请日：2007-05-03
申请人： IMMUNIVEST CORP , GREVE JAN , SCHREUDER FREDERIK
发明人： GREVE JAN , SCHREUDER FREDERIK
IPC分类号： G06F19/00 , G06T7/40
CPC分类号： G01N33/54326 , Y10T436/143333
摘要： Devices and methods for automated collection and image analysis are disclosed that enable identification or classification of microscopic objects aligned or deposited on surfaces. Such objects, e.g. detectably labeled rare target cells, are magnetically or non-magnetically immobilized and subjected to Time Delay Integration imaging (TDI). Incorporation of TDl technology into image cytometry analysis, like CellTracks®, makes it possible to image moving objects with very high sensitivity and signal-to-noise ratios. Implementation of TDI camera technology with dual excitation and multispectral imaging of enriched.rare cells provides a rapid system for detection, enumeration, differentiation and characterization of imaged rare cells on the basis of size, morphology and immunophenotype.
摘要翻译：公开了用于自动收集和图像分析的装置和方法，其能够识别或分类对准或沉积在表面上的微观物体。这些物体，例如。可检测标记的罕见靶细胞是磁性或非磁性固定的并经受时间延迟积分成像（TDI）。结合TDI技术进行图像细胞分析，如CellTracks®，可以以非常高的灵敏度和信噪比对运动物体进行成像。基于大小，形态和免疫表型，实现具有双激发和多光谱成像的TDI相机技术，用于富集细胞提供快速检测，计数，分化和表征成像稀有细胞的系统。

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