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1. 发明申请

WO2013113707A1 SYSTEM FOR DETECTING GENES IN TISSUE SAMPLES 审中-公开
标题翻译：用于检测组织样本中的基因的系统
公开(公告)号：WO2013113707A1
公开(公告)日：2013-08-08
申请号：PCT/EP2013/051705
申请日：2013-01-29
申请人： VENTANA MEDICAL SYSTEMS, INC. , F. HOFFMANN-LA ROCHE AG , BAMFORD, Pascal , CHUKKA, Srinivas , MARTIN, Jim F. , SARKAR, Anindya , SERTEL, Olcay , SUZUE, Ellen , VARANGAONKAR, Harshal
发明人： BAMFORD, Pascal , CHUKKA, Srinivas , MARTIN, Jim F. , SARKAR, Anindya , SERTEL, Olcay , SUZUE, Ellen , VARANGAONKAR, Harshal
IPC分类号： G06K9/00 , G06T7/00 , G06T7/40 , C12Q1/68
CPC分类号： G06K9/00147 , C12Q1/6813 , G06T7/0012 , G06T7/90 , G06T2207/10024 , G06T2207/10056 , G06T2207/30024
摘要： A computer-based specimen analyzer (10) is configured to detect a level of expression of genes in a cell sample by detecting dots that represent differently stained genes and chromosomes in a cell. The color of the stained genes and the chromosomes is enhanced and filtered to produce a dot mask that defines areas in the image that are genes, chromosomes, or non-genetic material. Metrics are determined for the dots and/or pixels in the image of the cell in areas corresponding to the dots. The metrics are fed to a classifier that separates genes from chromosomes. The results of the classifier are counted to estimate the expression level of genes in the tissue samples.
摘要翻译：基于计算机的样本分析器（10）被配置为通过检测代表细胞中不同染色的基因和染色体的点来检测细胞样品中基因的表达水平。染色基因和染色体的颜色被增强和过滤以产生定义图像中基因，染色体或非遗传物质区域的点掩模。针对与点对应的区域中的单元格的图像中的点和/或像素确定度量。将度量提供给将染色体分离基因的分类器。计算分类器的结果以估计组织样品中基因的表达水平。

2. 发明申请

WO2018065434A1 DIGITAL PATHOLOGY SYSTEM AND ASSOCIATED WORKFLOW FOR PROVIDING VISUALIZED WHOLE-SLIDE IMAGE ANALYSIS 审中-公开
标题翻译：数字病理学系统和相关的工作流程，用于提供可视化的整体幻灯片图像分析
公开(公告)号：WO2018065434A1
公开(公告)日：2018-04-12
申请号：PCT/EP2017/075113
申请日：2017-10-04
申请人： VENTANA MEDICAL SYSTEMS, INC. , F. HOFFMANN-LA ROCHE AG
发明人： BARNES, Michael , BREDNO, Joerg , CHUKKA, Srinivas , GUETTER, Christoph , LORSAKUL, Auranuch , SARKAR, Anindya , SUZUE, Ellen
IPC分类号： G06T7/00
摘要： A digital pathology system and associated method and computer program product provide a quantitative analysis of entire tissue slides as well as intuitive, effective, fast, and precise quantification of biomarker expressions across relevant areas of the entire tissue slides. The digital pathology system enables a novel workflow that allows the user to efficiently outline clinically relevant morphology in its entirety, including solid tumor areas. Quantitative analysis results are then efficiently and intuitively provided to the user for all tissue content (i.e., millions of cells) within seconds. This efficiency is made possible by a pre-computation step that computes and stores image analysis results for later retrieval. Visualizing vast amount of data effectively is another component of the system that provides information and confidence to the user about the biomarker expression levels.
摘要翻译：数字病理学系统和相关方法以及计算机程序产品提供对整个组织切片的定量分析以及对整个组织切片的相关区域的生物标记表达的直观，有效，快速和精确的量化。数字病理系统实现了一种新颖的工作流程，使用户能够有效地勾勒整个临床相关形态，包括实体肿瘤区域。然后在数秒内将定量分析结果有效且直观地提供给用户以获得所有组织含量（即，数百万个细胞）。通过计算和存储图像分析结果以供稍后检索的预计算步骤，可以提高效率。有效显示大量数据是该系统的另一个组成部分，为用户提供有关生物标志物表达水平的信息和信心。

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