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1. 发明申请

WO2008132729A3 PROMOTERS EXHIBITING ENDOTHELIAL CELL SPECIFICITY AND METHODS OF USING SAME FOR REGULATION OF ANGIOGENESIS 审中-公开
标题翻译：展示内皮细胞特异性及其使用方法用于调节血管生成
公开(公告)号：WO2008132729A3
公开(公告)日：2009-10-22
申请号：PCT/IL2008000543
申请日：2008-04-27
申请人： VASCULAR BIOGENICS LTD , BREITBART EYAL , BANGIO LIVNAT , HARATS DROR , PELED MICHAEL , GREENBERGER SHOSHANA
发明人： BREITBART EYAL , BANGIO LIVNAT , HARATS DROR , PELED MICHAEL , GREENBERGER SHOSHANA
IPC分类号： A61K48/00 , C12N15/00
CPC分类号： C12N15/86 , A61K48/00 , C12N15/85 , C12N2710/10343 , C12N2830/008
摘要： Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
摘要翻译：公开了显示内皮细胞特异性启动子活性的分离的多核苷酸序列，新的顺式调节元件及其使用方法，其能够治疗以异常新生血管形成或细胞生长为特征的疾病。

2. 发明申请

WO2007096882A3 PROMOTERS EXHIBITING ENDOTHELIAL CELL SPECIFICITY AND METHODS OF USING SAME FOR REGULATION OF ANGIOGENESIS 审中-公开
标题翻译：显示内皮细胞特异性的促进剂及其用于调节血管生成的方法
公开(公告)号：WO2007096882A3
公开(公告)日：2009-02-12
申请号：PCT/IL2007000242
申请日：2007-02-22
申请人： VASCULAR BIOGENICS LTD , HARATS DROR , GREENBERGER SHOSHANA , BREITBART EYAL , BANGIO LIVNAT , PELED MICHAEL
发明人： HARATS DROR , GREENBERGER SHOSHANA , BREITBART EYAL , BANGIO LIVNAT , PELED MICHAEL
IPC分类号： A61K48/00 , A61K31/198 , A61K31/573 , C12N15/861
CPC分类号： A61K38/1858 , A01K2267/0331 , A01K2267/0393 , A61K31/198 , A61K31/573 , A61K38/1866 , A61K48/00 , A61K48/0058 , A61K48/0066 , C12N15/85 , C12N15/86 , C12N2710/10343 , C12N2830/002 , C12N2830/008 , C12N2840/203
摘要： Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
摘要翻译：公开了显示内皮细胞特异性启动子活性的独立多核苷酸序列，新型顺式调控元件及其使用方法，其能够治疗以异常新血管形成或细胞生长为特征的疾病。

3. 发明申请

WO2011083464A3 METHODS FOR USE OF A SPECIFIC ANTI-ANGIOGENIC ADENOVIRAL AGENT 审中-公开
标题翻译：使用特异性抗血管形成腺病毒剂的方法
公开(公告)号：WO2011083464A3
公开(公告)日：2011-11-10
申请号：PCT/IL2011000007
申请日：2011-01-05
申请人： VASCULAR BIOGENICS LTD , COHEN YAEL , SHER NAAMIT , FEIGE EREZ , BANGIO LIVNAT , BREITBART EYAL
发明人： COHEN YAEL , SHER NAAMIT , FEIGE EREZ , BANGIO LIVNAT , BREITBART EYAL
IPC分类号： C12N15/00
CPC分类号： C12N15/86 , A61K38/177 , A61K48/005 , A61K48/0058 , A61K48/0083 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C12N15/87 , C12N2799/022 , C12N2830/008 , C12N2830/85
摘要： Anti-angiogenic adenovirus vectors, and therapeutic use thereof are provided, and more particularly, but not exclusively, clinical protocols for treatment of solid tumors in patients with an Ad5-PPE-1-3X-fas-chimera adenovirus vector.
摘要翻译：提供了抗血管生成腺病毒载体及其治疗用途，并且更具体地但非排他性地提供了用于治疗具有Ad5-PPE-1-3X-fas-嵌合体腺病毒载体的患者中的实体瘤的临床方案。

4. 发明申请

WO2008015675A2 POLYPEPTIDES AND POLYNUCLEOTIDES ENCODING SAME AND USE THEREOF IN THE TREATMENT OF MEDICAL CONDITIONS ASSOCIATED WITH ISCHEMIA 审中-公开
标题翻译：编码它们的多肽和多核苷酸及其在治疗与ISCHEMIA相关的医疗条件中的应用
公开(公告)号：WO2008015675A2
公开(公告)日：2008-02-07
申请号：PCT/IL2007000959
申请日：2007-07-31
申请人： VASCULAR BIOGENICS LTD , BREITBART EYAL , BANGIO LIVNAT , TAL RESHEF
发明人： BREITBART EYAL , BANGIO LIVNAT , TAL RESHEF
IPC分类号： A61K48/00
CPC分类号： C07K14/4705 , A61K48/005 , A61K48/0058 , C07K14/4702 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2710/10371 , C12N2799/022 , C12N2799/04 , C12N2830/002 , C12N2830/008
摘要： An isolated polynucleotide is disclosed comprising a nucleic acid sequence encoding a polypeptide having an amino acid sequence of HIF-1alpha, the polypeptide being stably expressed and constitutively active. Isolated polypeptides encoded by same are also disclosed and uses thereof.
摘要翻译：公开了分离的多核苷酸，其包含编码具有HIF-1α的氨基酸序列的多肽的核酸序列，所述多肽具有稳定表达并具有组成型活性。还公开了由相同编码的分离的多肽及其用途。

5. 发明申请

WO2009050692A3 PLATELET-ACTIVATING FACTOR (PAF) ANALOGS AND USES THEREOF 审中-公开
标题翻译：弹药因子（PAF）模拟物及其用途
公开(公告)号：WO2009050692A3
公开(公告)日：2010-03-04
申请号：PCT/IL2008001315
申请日：2008-10-05
申请人： VASCULAR BIOGENICS LTD , MENDEL ITZHAK , YACOV NIVA , BREITBART EYAL
发明人： MENDEL ITZHAK , YACOV NIVA , BREITBART EYAL
IPC分类号： A61K9/127
CPC分类号： A61K31/685
摘要： Disclosed are novel methods and compositions for treating inflammatory diseases and disorders, utilizing structural analogs of platelet activating factor (PAF).
摘要翻译：公开了利用血小板活化因子（PAF）的结构类似物治疗炎性疾病和病症的新方法和组合物。

6. 发明申请

WO2010041242A3 OXIDIZED THIOPHOSPHOLIPID COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：氧化硫代磷脂化合物及其用途
公开(公告)号：WO2010041242A3
公开(公告)日：2010-06-03
申请号：PCT/IL2009000949
申请日：2009-10-01
申请人： VASCULAR BIOGENICS LTD , BREITBART EYAL , KOVALEVSKI-ISHAI ETI , FEIGE EREZ , MENDEL ITZHAK , ZINIUK ZEEV , HALPERIN GIDEON
发明人： BREITBART EYAL , KOVALEVSKI-ISHAI ETI , FEIGE EREZ , MENDEL ITZHAK , ZINIUK ZEEV , HALPERIN GIDEON
IPC分类号： A01N57/00 , A61K31/66
CPC分类号： C07F9/10
摘要： Novel oxidized thiophospholipids are provided herein, as well as methods for producing same, and uses thereof in treating or preventing an inflammation associated with endogenous oxidized lipids and related conditions. Exemplary oxidized thiophospholipid according to embodiments described herein have the formula: (I) wherein X1, X2, A1, A2, B', B'', D' and D'' are as described herein.
摘要翻译：本文提供了新的氧化型硫磷脂，以及其生产方法及其用于治疗或预防与内源性氧化脂质相关的炎症和相关病症的用途。根据本文所述实施方案的示例性氧化型硫代磷脂具有式（I），其中X 1，X 2，A 1，A 2，B'，B“，D'和D”如本文所述。

7. 发明申请

WO2010052718A1 OXIDIZED LIPID COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：氧化脂质化合物及其用途
公开(公告)号：WO2010052718A1
公开(公告)日：2010-05-14
申请号：PCT/IL2009001049
申请日：2009-11-05
申请人： VASCULAR BIOGENICS LTD , KOVALEVSKI-ISHAI ETI , ZINIUK ZEEV , HALPERIN GIDEON , MENDEL ITZHAK , FEIGE EREZ , YACOV NIVA , BREITBART EYAL
发明人： KOVALEVSKI-ISHAI ETI , ZINIUK ZEEV , HALPERIN GIDEON , MENDEL ITZHAK , FEIGE EREZ , YACOV NIVA , BREITBART EYAL
IPC分类号： A01N57/26
CPC分类号： C07F9/091 , C07C59/125 , C07F9/106
摘要： Novel oxidized lipids are provided herein, as well as methods for producing same, and uses thereof in treating or preventing an inflammation associated with endogenous oxidized lipids and related conditions.
摘要翻译：本文提供了新的氧化脂质，以及其生产方法及其在治疗或预防与内源性氧化脂质和相关病症相关的炎症中的用途。

8. 发明申请

WO2006109312A3 COMPOSITIONS CONTAINING BETA 2-GLYCOPROTEIN I-DERIVED PEPTIDES FOR THE PREVENTION AND/OR TREATMENT OF VASCULAR DISEASE 审中-公开
标题翻译：含有β-谷氨酸蛋白I衍生肽的组合物用于预防和/或治疗血管疾病
公开(公告)号：WO2006109312A3
公开(公告)日：2009-01-08
申请号：PCT/IL2006000467
申请日：2006-04-11
申请人： VASCULAR BIOGENICS LTD , BREITBART EYAL , YACOV NIVA
发明人： BREITBART EYAL , YACOV NIVA
IPC分类号： A61K31/739 , A61K38/00 , C07K14/00
CPC分类号： A61K38/1709
摘要： Methods and compositions employing beta2-glycoprotein-1 ( 2GPI)-derived peptides and combinations thereof effective in inducing mucosal tolerance to atheroma related antigens and effective in inhibiting inflammatory processes contributing to atheromatous vascular disease and sequalae are provided.
摘要翻译：提供了使用β2-糖蛋白-1（2GPI）衍生的肽及其组合有效诱导对动脉粥样化相关抗原的粘膜耐受并且有效抑制有助于动脉粥样化血管疾病和后遗症的炎症过程的方法和组合物。

9. 发明申请

WO2013121300A3 METHODS FOR TREATING PSORIASIS AND VASCULAR INFLAMMATION 审中-公开
标题翻译：治疗PSORIASIS和血管炎的方法
公开(公告)号：WO2013121300A3
公开(公告)日：2013-12-27
申请号：PCT/IB2013000780
申请日：2013-02-15
申请人： VASCULAR BIOGENICS LTD
发明人： SHER NAAMIT , LEUBITZ ANDREA , BREITBART EYAL
IPC分类号： A61K31/685
CPC分类号： A61K31/685 , A61K9/146 , A61K9/4866 , A61K45/06 , A61K47/02 , A61K47/10
摘要： Described are methods of decreasing vascular inflammation in a subject suffering from a chronic autoimmune or chronic inflammatory disease by administering to the subject a therapeutically effective amount of VB-201, wherein the therapeutically effective amount is from about 20 mg/day to about 160 mg/day, optionally administered in two daily sub-doses. Also described are methods of treating inflammation associated with an implant (e.g., a breast implant) in a subject by administering to the subject a therapeutically effective amount of VB-201, wherein the therapeutically effective amount is from about 20 mg/day to about 160 mg/day, optionally administered in two daily sub-doses. Further described are methods of treating psoriasis (e.g., active plaque psoriasis) in a subject by administering to the subject a therapeutically effective amount of VB-201, wherein the therapeutically effective amount is from about 80 mg/day to about 160 mg/day, optionally administered in two daily sub-doses.
摘要翻译：描述了通过向受试者施用治疗有效量的VB-201来减少患有慢性自身免疫性或慢性炎性疾病的受试者的血管炎症的方法，其中治疗有效量为约20mg /天至约160mg / 天，任选地以两个每日次剂量施用。还描述了通过向受试者施用治疗有效量的VB-201来治疗与受试者中的植入物（例如，乳房植入物）相关的炎症的方法，其中治疗有效量为约20mg /天至约160 mg /天，任选地以两个每日次剂量施用。进一步描述的是通过向受试者施用治疗有效量的VB-201治疗受试者的牛皮癣（例如，活性斑块性银屑病）的方法，其中治疗有效量为约80mg /天至约160mg /天，任选地以两个每日次剂量施用。

10. 发明申请

WO2017021855A3 MOTILE SPERM DOMAIN CONTAINING PROTEIN 2 AND INFLAMMATION 审中-公开
标题翻译：含有MOTILE SPERM域的蛋白2和炎症
公开(公告)号：WO2017021855A3
公开(公告)日：2017-04-06
申请号：PCT/IB2016054582
申请日：2016-07-29
申请人： VASCULAR BIOGENICS LTD
发明人： MENDEL ITZHAK , PROPHETA-MEIRAN OSHRAT , SALEM YANIV , SHOHAM ANAT , BREITBART EYAL
IPC分类号： A61K38/00 , C07C59/125 , C07F9/09 , C12N9/20
CPC分类号： A61K48/00 , A61K2039/505 , C07K16/28 , C12N15/113 , C12N2310/14 , C12N2310/531
摘要： Disclosed herein are methods of treating, preventing, or reducing the incidence of an inflammatory disease or disorder and methods of inhibiting, preventing, or reducing the incidence of one or more activities in a cell with an inhibitor of a Motile Sperm Domain containing Protein 2 (MOSPD2). Also disclosed are inhibitors of MOSPD2 and pharmaceutical compositions containing MOSPD2 inhibitors.
摘要翻译：本文公开了治疗，预防或降低炎性疾病或病症的发生的方法以及用含有运动精子结构域的蛋白质2抑制剂抑制，预防或减少细胞中一种或多种活性的发生的方法（ MOSPD2）。还公开了含有MOSPD2抑制剂的MOSPD2抑制剂和药物组合物。

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