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1. 发明申请

WO2016028699A8 BIOMARKERS FOR DIAGNOSIS AND MANAGEMENT OF NEURO-IMMUNOLOGICAL DISEASES 审中-公开
标题翻译：生物标志物用于神经免疫疾病的诊断和管理
公开(公告)号：WO2016028699A8
公开(公告)日：2016-11-17
申请号：PCT/US2015045549
申请日：2015-08-17
申请人： US HEALTH , MONTANA STATE UNIV
发明人： BIELEKOVA BIBIANA , KOMORI MIKA , KOSA PETER , GREENWOOD MARK C , BARBOUR CHRISTOPHER
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2333/705 , G01N2800/285 , G01N2800/52 , G01N2800/60
摘要： Biomarkers associated with neuroimmunological disease are described. The disclosed biomarkers are secreted proteins identified in cerebral spinal fluid (CSF) samples of patients with neurological disease. The disclosed biomarkers identify patients with intrathecal inflammation, distinguish multiple sclerosis (MS) patients from patients with other types of inflammatory neurological diseases and from subjects without MS, distinguish progressive MS patients from patients with relapsing-remitting MS, identify subjects with non-MS inflammatory neurological diseases, differentiate healthy subjects from patients with any type of neurological disease, and/or identify subjects with increased disability, CNS tissue damage and/or neurodegeneration. Process-specific biomarkers that can be used in place of a brain biopsy to identify immune cell infiltration and/or activation in the CNS are also described. Methods of treating subject with neurological disease, and methods of evaluating the efficacy of particular treatments, based on detection of the disclosed biomarkers are also described.
摘要翻译：描述了与神经免疫疾病相关的生物标志物。所公开的生物标记是在患有神经疾病的患者的脑脊液（CSF）样品中鉴定的分泌蛋白。所公开的生物标志物鉴定患有鞘内炎症的患者，区分多发性硬化症（MS）患者与其他类型炎症性神经疾病患者以及无MS患者，将进行性MS患者与具有复发缓解MS的患者区分开来，鉴别患有非MS炎性神经疾病，将健康受试者与任何类型的神经疾病患者区分开，和/或鉴定残疾增加，CNS组织损伤和/或神经变性的受试者。还描述了可用于代替脑活检以鉴定CNS中免疫细胞浸润和/或活化的过程特异性生物标志物。还描述了基于检测所公开的生物标志物来治疗患有神经疾病的受试者的方法以及评估特定治疗的功效的方法。

2. 发明申请

WO2016028699A2 BIOMARKERS FOR DIAGNOSIS AND MANAGEMENT OF NEURO-IMMUNOLOGICAL DISEASES 审中-公开
标题翻译：生物标志物诊断和管理神经免疫缺陷病毒
公开(公告)号：WO2016028699A2
公开(公告)日：2016-02-25
申请号：PCT/US2015045549
申请日：2015-08-17
申请人： US HEALTH , UNIV MONTANA STATE
发明人： BIELEKOVA BIBIANA , KOMORI MIKA , KOSA PETER , GREENWOOD MARK C , BARBOUT CHRISTOPHER
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2333/705 , G01N2800/285 , G01N2800/52 , G01N2800/60
摘要： Biomarkers associated with neuroimmunological disease are described. The disclosed biomarkers are secreted proteins identified in cerebral spinal fluid (CSF) samples of patients with neurological disease. The disclosed biomarkers identify patients with intrathecal inflammation, distinguish multiple sclerosis (MS) patients from patients with other types of inflammatory neurological diseases and from subjects without MS, distinguish progressive MS patients from patients with relapsing-remitting MS, identify subjects with non-MS inflammatory neurological diseases, differentiate healthy subjects from patients with any type of neurological disease, and/or identify subjects with increased disability, CNS tissue damage and/or neurodegeneration. Process-specific biomarkers that can be used in place of a brain biopsy to identify immune cell infiltration and/or activation in the CNS are also described. Methods of treating subject with neurological disease, and methods of evaluating the efficacy of particular treatments, based on detection of the disclosed biomarkers are also described.
摘要翻译：描述了与神经免疫疾病相关的生物标志物。所公开的生物标志物是在具有神经疾病的患者的脑脊髓液（CSF）样品中鉴定的分泌蛋白质。所公开的生物标志物识别患有鞘内炎症的患者，区分多发性硬化（MS）患者与患有其他类型炎症性神经疾病的患者和来自不具有MS的受试者，区分进行性MS患者与复发缓解MS患者，鉴定具有非MS炎性的受试者神经疾病，将健康受试者与患有任何类型的神经疾病的患者区分开来，和/或识别残疾增加，CNS组织损伤和/或神经变性的受试者。还描述了可用于代替脑活检以鉴定CNS中的免疫细胞浸润和/或激活的过程特异性生物标志物。还描述了基于所公开的生物标志物的检测来治疗患有神经疾病的受试者的方法和评估特定治疗的功效的方法。

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