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1. 发明申请

WO0218584A3 XAGE-1, A GENE EXPRESSED IN MULTIPLE CANCERS, AND USES THEREOF 审中-公开
标题翻译： XAGE-1，多基因中表达的基因及其用途
公开(公告)号：WO0218584A3
公开(公告)日：2003-01-16
申请号：PCT/US0127258
申请日：2001-08-31
申请人： US GOV HEALTH & HUMAN SERV , PASTAN IRA H , LIU XIU FEN , BERA TAPAN K , LEE BYUNGKOOK , EGLAND KRISTI A
发明人： PASTAN IRA H , LIU XIU FEN , BERA TAPAN K , LEE BYUNGKOOK , EGLAND KRISTI A
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , A61K31/7088 , A61K38/17 , C07K16/18 , C12Q1/68
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention relates to the surprising discovery that XAGE-1 is translated as two proteins, a 9 kD protein, termed p9, and a 16.3 kD protein, termed p16. The invention further relates to the surprising discovery that XAGE-1 is expressed in a number of important human cancers, specifically: prostate cancer, lung cancer, ovarian cancer, breast cancer, glioblastoma, pancreatic cancer, T cell lymphoma, melanoma, and histocytic lymphoma. The proteins p9 and p16, immunogenic fragments thereof, analogs of these proteins, and nucleic acids encoding these proteins, fragments, or analogs, can be administered to persons with XAGE-1 expressing cancers to raise or augment an immune response to the cancer. The invention further provides nucleic acid sequences encoding the proteins, as well as expression vectors, host cells, and antibodies to the proteins. Further, the invention provides immunoconjugates that comprise an antibody to p16 or to p9, and an effector molecule, such as a label, a radioisotope, or a toxin. The invention also provides methods of inhibiting the growth of XAGE-1 expressing cells by contacting them with immunoconjugates comprising an anti- p9 or p16 antibody and a toxic moiety. Further, the invention provides kits for detecting the presence of p9 or p16 in a sample.
摘要翻译：本发明涉及令人惊奇的发现，即XAGE-1被翻译为两种蛋白质，称为p9的9kD蛋白质，称为p16的16.3kD蛋白质。本发明还涉及令人惊奇的发现：XAGE-1在许多重要的人类癌症中表达，特别是前列腺癌，肺癌，卵巢癌，乳腺癌，成胶质细胞瘤，胰腺癌，T细胞淋巴瘤，黑素瘤和组织细胞淋巴瘤。蛋白质p9和p16，其免疫原性片段，这些蛋白质的类似物，以及编码这些蛋白质，片段或类似物的核酸可以被给予具有XAGE-1表达癌症的人，以提高或增加对癌症的免疫应答。本发明还提供编码蛋白质的核酸序列，以及表达载体，宿主细胞和对蛋白质的抗体。此外，本发明提供包含对p16或p9的抗体的免疫缀合物和效应分子，例如标记物，放射性同位素或毒素。本发明还提供了通过使它们与包含抗p9或p16抗体和毒性部分的免疫缀合物接触来抑制表达XAGE-1细胞生长的方法。此外，本发明提供了用于检测样品中p9或p16的存在的试剂盒。

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