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1. 发明申请

WO2012129165A3 NOVEL ANTIMICROBIAL ACTIVITY OF CHICKEN NK-2 PEPTIDE AGAINST APICOMPLEXAN PROTOZOA 审中-公开
标题翻译：鸡抗NK-2肽抗APICOMPLEXAN PROTOZOA的新型抗微生物活性
公开(公告)号：WO2012129165A3
公开(公告)日：2012-11-08
申请号：PCT/US2012029659
申请日：2012-03-19
申请人： US AGRICULTURE , LILLEHOJ HYUN , LEE SUNG HYEN , HONG YEONG HO
发明人： LILLEHOJ HYUN , LEE SUNG HYEN , HONG YEONG HO
IPC分类号： C07K14/47 , A61K38/17 , A61P31/00
CPC分类号： C07K14/465 , A61K38/17 , C07K14/52
摘要： NK-2 synthetic peptide derived from cationic core region of porcine NK-lysin has an antimicrobial and antitumor polypeptide that is considered to play a pivotal role in innate defense immunity. To evaluate the antimicrobial properties of synthetic chicken NK-lysin peptides, we investigated cytolytic activity against apicomplexan parasites like Eimeria sporozoites, Neospora tachyzoites and Cryptosporidum sporozoites. The chicken NK-2 (cNK-2) lytic peptide which corresponds to amino acid residues of porcine NK-2 peptide significantly disrupted Eimeria and Cryptosporidum sporozoites and Neospora tachyzoites. In contrast, no bactericidal activity was observed on E. coli BMH71-18. The cNK-2 lytic peptide is novel antimicrobial agent which can be used to intervene and treat economically costly infections in the animal industry.
摘要翻译：来源于猪NK-lysin的阳离子核心区域的NK-2合成肽具有抗原和抗肿瘤多肽，被认为在先天免疫中起关键作用。为了评估合成鸡NK-赖氨酸肽的抗菌性能，我们研究了针对致密虫寄生虫如艾美球虫子孢子，新孢子虫速殖子和隐孢子虫子孢子的溶细胞活性。对应于NK-2肽氨基酸残基的鸡NK-2（cNK-2）裂解肽显着破坏艾美球虫和隐孢子虫子孢子和新孢子虫速殖子。相反，在大肠杆菌BMH71-18上没有观察到杀菌活性。 cNK-2裂解肽是新型抗菌剂，可用于干预和治疗动物行业经济上昂贵的感染。

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