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1. 发明申请

WO2009140429A3 MICELLIC ASSEMBLIES 审中-公开
公开(公告)号：WO2009140429A3
公开(公告)日：2009-11-19
申请号：PCT/US2009/043849
申请日：2009-05-13
申请人： UNIVERSITY OF WASHINGTON , PHASERX , STAYTON, Patrick, S. , HOFFMAN, Alan, S. , CONVERTINE, Anthony, J. , DUVALL, Craig, L. , BENOIT, Danielle , OVERELL, Robert , JOHNSON, Paul , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
发明人： STAYTON, Patrick, S. , HOFFMAN, Alan, S. , CONVERTINE, Anthony, J. , DUVALL, Craig, L. , BENOIT, Danielle , OVERELL, Robert , JOHNSON, Paul , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
IPC分类号： C08F299/00 , C08F299/02 , C08F299/04 , C08F293/00 , C12N15/87 , A61K48/00
摘要： Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.

2. 发明申请

WO2009140423A3 TARGETED POLYMER BIOCONJUGATES 审中-公开
公开(公告)号：WO2009140423A3
公开(公告)日：2009-11-19
申请号：PCT/US2009/043839
申请日：2009-05-13
申请人： UNIVERSITY OF WASHINGTON , PHASERX , JOHNSON, Paul , STAYTON, Patrick, S. , HOFFMAN, Alan, S. , CONVERTINE, Anthony, J. , DUVALL, Craig, L. , BENOIT, Danielle , LEE, Chen-Chang , OVERELL, Robert , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
发明人： JOHNSON, Paul , STAYTON, Patrick, S. , HOFFMAN, Alan, S. , CONVERTINE, Anthony, J. , DUVALL, Craig, L. , BENOIT, Danielle , LEE, Chen-Chang , OVERELL, Robert , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
IPC分类号： C07H21/02
摘要： Polymer bioconjugate having a RNAi agent covalently coupled to the alpha or omega end of a pH-dependent membrane-destabilizing polymer.

3. 发明申请

WO2009140421A2 POLYMERIC CARRIER 审中-公开
标题翻译：聚合载体
公开(公告)号：WO2009140421A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/043837
申请日：2009-05-13
申请人： UNIVERSITY OF WASHINGTON , PHASERX, INC. , STAYTON, Patrick, S. , HOFFMAN, Allan, S. , CONVERTINE, Anthony, J. , DUVALL, Craig, L. , BENOIT, Danielle , OVERELL, Robert , JOHNSON, Paul , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
发明人： STAYTON, Patrick, S. , HOFFMAN, Allan, S. , CONVERTINE, Anthony, J. , DUVALL, Craig, L. , BENOIT, Danielle , OVERELL, Robert , JOHNSON, Paul , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
IPC分类号： A61K47/34 , A61K48/00 , A61K31/7088
CPC分类号： A61K47/488 , A61K9/1075 , A61K47/549 , A61K47/58 , A61K47/60 , A61K47/6907 , C08F293/005 , C12N15/113 , C12N15/87 , C12N2310/11 , C12N2310/14
摘要： Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell.
摘要翻译：本文提供适合于将多核苷酸（例如寡核苷酸）和/或其它治疗剂递送至活细胞的聚合物载体。

4. 发明申请

WO2009140432A2 MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：用于细胞内递送治疗药物的细胞
公开(公告)号：WO2009140432A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/043853
申请日：2009-05-13
申请人： UNIVERSITY OF WASHINGTON , PhaseRx, Inc. , JOHNSON, Paul , STAYTON, Patrick, S. , HOFFMAN, Allan, S. , CONVERTINE, Anthony, J. , OVERELL, Robert , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
发明人： JOHNSON, Paul , STAYTON, Patrick, S. , HOFFMAN, Allan, S. , CONVERTINE, Anthony, J. , OVERELL, Robert , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
IPC分类号： A61K9/127 , A61K48/00 , A61K47/38 , A61K31/7105
CPC分类号： A61K9/1075 , A61K9/0019 , A61K31/7105 , A61K47/551 , A61K47/58 , A61K47/60 , A61K47/6907 , A61K48/0041 , C08F293/005 , C08F2438/03 , C12N15/111 , C12N2320/32
摘要： Composition comprising a polymeric micelle and an associated polynucleotide.
摘要翻译：包含聚合胶束和相关多核苷酸的组合物。

5. 发明申请

WO2010021770A1 HETEROGENEOUS POLYMERIC MICELLES FOR INTRACELLULAR DELIVERY 审中-公开
标题翻译：异源聚合物细胞用于细胞内递送
公开(公告)号：WO2010021770A1
公开(公告)日：2010-02-25
申请号：PCT/US2009/043859
申请日：2009-05-13
申请人： UNIVERSITY OF WASHINGTON , PHASERX, INC. , JOHNSON, Paul , STAYTON, Patrick, S. , HOFFMAN, Allan, S. , OVERELL, Robert , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
发明人： JOHNSON, Paul , STAYTON, Patrick, S. , HOFFMAN, Allan, S. , OVERELL, Robert , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
IPC分类号： A61K9/127 , A61K48/00 , A61K47/34 , A61K31/7088 , A61K31/7105
CPC分类号： A61K9/0019 , A61K9/1075 , A61K47/58 , C08L53/00 , C12N15/88 , C08L2666/24
摘要： Compositions comprising a heterogeneous polymeric micelle and an agent (e.g., a polynucleotide) associated with the micelle are disclosed, together with methods for intracellular delivery of such agent.
摘要翻译：公开了包含非均相聚合物胶束和与胶束相关联的试剂（例如，多核苷酸）的组合物，以及用于细胞内递送该试剂的方法。

6. 发明申请

WO2010053597A2 MICELLES OF HYDROPHILICALLY SHIELDED MEMBRANE-DESTABILIZING COPOLYMERS 审中-公开
标题翻译：亲水屏蔽膜失活共聚物的胶束
公开(公告)号：WO2010053597A2
公开(公告)日：2010-05-14
申请号：PCT/US2009/043860
申请日：2009-05-13
申请人： UNIVERSITY OF WASHINGTON/////////////////////-+ , PHASERX, INC. , JOHNSON, Paul , STAYTON, Patrick, S. , HOFFMAN, Allan, S. , OVERELL, Robert , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
发明人： JOHNSON, Paul , STAYTON, Patrick, S. , HOFFMAN, Allan, S. , OVERELL, Robert , GALL, Anna , PRIEVE, Mary , PASCHAL, Amber , DIAB, Charbel , DE, Priyadarsi
CPC分类号： A61K9/1075 , A61K47/549 , A61K47/58 , A61K47/60 , A61K47/6907
摘要： Provided herein are micelles comprising a plurality of copolymers. In certain instances, micelles provided herein are pH sensitive particles.
摘要翻译：本文提供了包含多种共聚物的胶束。在某些情况下，本文提供的胶束是pH敏感粒子。

7. 发明申请

WO2009140427A3 DIBLOCK COPOLYMERS AND POLYNUCLEOTIDE COMPLEXES THEREOF FOR DELIVERY INTO CELLS 审中-公开
公开(公告)号：WO2009140427A3
公开(公告)日：2009-11-19
申请号：PCT/US2009/043847
申请日：2009-05-13
申请人： UNIVERSITY OF WASHINGTON , PHASERX , STAYTON, Patrick, S. , HOFFMAN, Alan, S. , CONVERTINE, Anthony, J. , BENOIT, Danielle , DUVALL, Craig, L. , JOHNSON, Paul , GALL, Anna
发明人： STAYTON, Patrick, S. , HOFFMAN, Alan, S. , CONVERTINE, Anthony, J. , BENOIT, Danielle , DUVALL, Craig, L. , JOHNSON, Paul , GALL, Anna
IPC分类号： C08F299/00 , C08F299/02 , C08F299/04 , C08F293/00 , C12N15/87 , A61K48/00
摘要： Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.

8. 发明申请

WO2010053596A1 BISPECIFIC INTRACELLULAR DELIVERY VEHICLES 审中-公开
标题翻译：双重细胞输送车辆
公开(公告)号：WO2010053596A1
公开(公告)日：2010-05-14
申请号：PCT/US2009/043852
申请日：2009-05-13
申请人： UNIVERSITY OF WASHINGTON , PHASERX , STAYTON, Patrick, S. , HOFFMAN, Alan, S. , CONVERTINE, Anthony , DUVALL, Craig, L. , OVERELL, Robert , JOHNSON, Paul
发明人： STAYTON, Patrick, S. , HOFFMAN, Alan, S. , CONVERTINE, Anthony , DUVALL, Craig, L. , OVERELL, Robert , JOHNSON, Paul
IPC分类号： A61K39/395 , A61K47/42 , A61K47/34 , A61K38/00
CPC分类号： A61K47/48715 , A61K47/48176 , A61K47/48246 , A61K47/48384 , A61K47/48507 , A61K47/48561 , A61K47/48569 , A61K47/48646 , A61K47/48676 , A61K47/58 , A61K47/64 , A61K47/6803 , A61K47/6835 , A61K47/6849 , A61K47/6851 , A61K47/6871 , A61K47/6879 , A61K47/6889 , C07K16/18 , C07K16/28 , C07K16/2881 , C07K16/32 , C07K16/40 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2319/10
摘要： A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.
摘要翻译：用于将试剂递送至细胞的组合物，其包含双特异性亲和试剂和pH响应性膜去稳定化聚合物。双特异性亲和试剂可以包括与第二亲和试剂共价连接的第一亲和试剂，其中第一亲和试剂与细胞表面上的分子结合，第二亲和试剂结合细胞内靶。

9. 发明申请

WO2020172191A1 SOLVENT-LESS IONIC LIQUID EPOXY RESIN 审中-公开
公开(公告)号：WO2020172191A1
公开(公告)日：2020-08-27
申请号：PCT/US2020/018682
申请日：2020-02-18
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , FRIESEN, Cody , BAUTISTA-MARTINEZ, Jose, Antonio , GONCHARENKO, Mykhaylo , JOHNSON, Paul
发明人： FRIESEN, Cody , BAUTISTA-MARTINEZ, Jose, Antonio , GONCHARENKO, Mykhaylo , JOHNSON, Paul
IPC分类号： C08G59/24 , C08G59/30 , C08G59/50 , C08G59/245 , C08G59/4021 , C08G59/4064 , C08G59/4071 , C08G59/5073 , C08G59/56
摘要： Solvent free epoxy systems are disclosed that can include a hardener compound H comprising: a molecular stmcture (R1-(Y1)n), wherein R1 is an ionic moiety, Y1 is a nucleophilic group, n is a between 2 and 10; and an ionic moiety A acting as a counter ion to R1; and an epoxy compound E comprising: a molecular structure (R2- Z1) n), wherein R2 is an ionic moiety, Z1 comprises an epoxide group, n is a between 2 and 10, and an ionic moiety B acting as a counter ion to R2. In embodiments, the epoxy compound E and/or the hardener H is comprised in a solvent-less ionic liquid. The systems can further include accelerators, crosslinkers, plasticizers, inhibitors, ionic hydrophobic and/or super-hydrophobic compounds, ionic hydrophilic compounds, ionic transitional hydrophobic/hydrophilic compounds, biological active compounds, and/or plasticizer compounds. Polymers made from the disclosed epoxy systems and their methods of use are described.

10. 发明申请

WO2012087305A1 AZIMUTHAL SATURATION LOGGING SYSTEMS AND METHODS 审中-公开
标题翻译： AZIMUTHAL饱和测井系统和方法
公开(公告)号：WO2012087305A1
公开(公告)日：2012-06-28
申请号：PCT/US2010/061735
申请日：2010-12-22
申请人： HALLIBURTON ENERGY SERVICES, INC. , LOTFY, Amr , JOHNSON, Paul , HVEDING, Frode
发明人： LOTFY, Amr , JOHNSON, Paul , HVEDING, Frode
IPC分类号： E21B49/00
CPC分类号： G01V3/38 , E21B47/00 , G01V11/00
摘要： Logging systems and methods to provide azimuthally-sensitive saturation logs. In some embodiments a processor operates on formation porosity and resistivity measurements from an azimuthally-sensitive logging tool assembly to derive a saturation log having a dependence on tool position and rotation angle, and possibly on radial distance as well. The processor may provide the log to a user via a screen, printer, or some other display mechanism. The logging tool assembly includes at least one tool to measure formation porosity. Suitable tools include a gamma density tool, a neutron density tool, a nuclear magnetic resonance tool, and an acoustic tool. The tool assembly further includes at least one tool to measure formation resistivity. Suitable tools include a laterolog tool, an induction tool, and a propagation resistivity tool. The tool assembly can be a wireline sonde, a tubing-conveyed logging assembly, or a logging while drilling tool assembly.
摘要翻译：记录系统和方法以提供方位角敏感的饱和日志。在一些实施例中，处理器对来自方位敏感测井工具组件的地层孔隙度和电阻率测量结果进行操作，以导出与工具位置和旋转角度有关的饱和度测井值，以及可能的径向距离。处理器可以经由屏幕，打印机或某些其他显示机构向用户提供日志。测井工具组件包括至少一个测量地层孔隙度的工具。合适的工具包括伽马密度工具，中子密度工具，核磁共振工具和声学工具。工具组件还包括至少一个测量地层电阻率的工具。合适的工具包括后工具，感应工具和传播电阻率工具。工具组件可以是有线探头，管道输送测井组件或钻井工具组件中的测井。

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