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1. 发明申请

WO2004074312A2 TRYPTOPHYLLIN PEPTIDES AND USES THEREOF 审中-公开
标题翻译：三苯乙烯肽及其用途
公开(公告)号：WO2004074312A2
公开(公告)日：2004-09-02
申请号：PCT/IB2004/000806
申请日：2004-02-04
申请人： UNIVERSITY OF ULSTER , SHAW, Chris , HIRST, David , CHEN, Tianbao , O'Rourke, Martin
发明人： SHAW, Chris , HIRST, David , CHEN, Tianbao , O'Rourke, Martin
IPC分类号： C07K
CPC分类号： C07K7/06 , A61K38/00 , C07K14/463
摘要： A vasodilatory tryptophyllin peptide, PdT-1, isolated from frog (Pachymedusa dacnicolor) defensive skin secretion, fragments and analogs thereof, are disclosed. The structure of PdT-1 is Lys-Pro-Hyp-Ala-Trp-Val-Pro.NH 2 (SEQ ID NO: 1). Also disclosed are tryptophyllin analogs, prodrugs including the peptides, fusion peptides and multimeric peptides including the peptide sequences, pharmaceutical compositions including PdT-1 and analogs thereof, nucleic acids encoding PdT-1 and analogs thereof, and methods of treatment of diseases for which vasodilation is beneficial using such peptides and nucleic acids.
摘要翻译：公开了从青蛙（Pachymedusa dacnicolor）防御性皮肤分泌中分离的血管扩张性色氨酰蛋白肽PdT-1，其片段和类似物。 PdT-1的结构是Lys-Pro-Hyp-Ala-Trp-Val-Pro.NH 2（SEQ ID NO：1）。还公开了色氨酰蛋白类似物，包括肽的前药，包括肽序列的融合肽和多聚体肽，包括PdT-1及其类似物的药物组合物，编码PdT-1的核酸及其类似物，以及治疗血管扩张疾病的方法使用这样的肽和核酸是有益的。

2. 发明申请

WO2004069857A2 “PEPTIDES, COMPOSITIONS AND USES THEREOF” 审中-公开
标题翻译： “肽，组合物及其用途”
公开(公告)号：WO2004069857A2
公开(公告)日：2004-08-19
申请号：PCT/GB2004/000470
申请日：2004-02-06
申请人： UUTECH LIMITED , SHAW, Chris , HIRST, David , CHEN, Tianbao , O'ROURKE, Martin , RAO, Pingfan
发明人： SHAW, Chris , HIRST, David , CHEN, Tianbao , O'ROURKE, Martin , RAO, Pingfan
IPC分类号： C07K
CPC分类号： C07K7/18 , A61K38/00
摘要： A bradykinin agonist peptide, maximakinin, isolated from toad (Bombina maxima) defensive skin secretion, fragments and analogs thereof, are disclosed. The structure of maximakinin is DLPKINRKGPRPPGFSPFR. Also disclosed are maximakinin analogs, prodrugs including the peptides, fusion peptides and multimeric peptides including the peptide sequences, pharmaceutical compositions including maximakinin and analogs thereof, prodrugs, fusion and multimeric peptides thereof, nucleic acids encoding maximakinin and analogs thereof, and nucleic acids encoding the fusion and multimeric peptides.
摘要翻译：公开了从蟾蜍（Bombina maxima）防御性皮肤分泌中分离出的缓激肽激动剂肽maximaxinin，其片段和类似物。最大蛋白的结构为DLPKINRKGPRPPGFSPFR。还公开了maximinin类似物，前药包括肽，融合肽和多聚体肽，包括肽序列，药物组合物，包括最大蛋白和其类似物，前药，其融合和多聚肽，编码最大蛋白及其类似物的核酸，以及编码融合和多聚体肽。

3. 发明申请

WO2004068928A2 PEPTIDES AND USES THEREOF 审中-公开
标题翻译：肽及其用途
公开(公告)号：WO2004068928A2
公开(公告)日：2004-08-19
申请号：PCT/GB2004/000473
申请日：2004-02-06
申请人： UUTECH LIMITED , SHAW, Chris , HIRST, David , CHEN, Tianbao , O'ROURKE, Martin , RAO, Pingfan
发明人： SHAW, Chris , HIRST, David , CHEN, Tianbao , O'ROURKE, Martin , RAO, Pingfan
IPC分类号： C07K7/18
CPC分类号： C07K7/18
摘要： A bradykinin B 2 -receptor antagonist peptide, kinestatin, isolated from toad (Bombina maxima) defensive skin secretion, and analogs thereof, is disclosed. The structure of kinestatin is pGlu-Leu/Ile-Pro-Gly-Leu/Ile-Gly-Pro-Leu/Ile-Arg-NH 2 . Also disclosed are kinestatin analogs, prodrugs including the peptides, fusion peptides and multimeric peptides including the peptide sequences, pharmaceutical compositions including kinestatin and analogs thereof, prodrugs, fusion and multimeric peptides thereof, nucleic acids encoding kinestatin and analogs thereof, and nucleic acids encoding the fusion and multimeric peptides. Kinestatin and analogs thereof (including the prodrugs and multimeric and/or fusion peptides) can be used to treat and/or prevent disorders associated with bradykinin, including cardiovascular disorders, inflammation, asthma, allergic rhinitis, pain, angiogenesis and the like.
摘要翻译：公开了从蟾蜍（Bombina maxima）防御性皮肤分泌物中分离出的缓激肽B2受体拮抗剂肽kinestatin及其类似物。 kinestatin的结构是pGlu-Leu / Ile-Pro-Gly-Leu / Ile-Gly-Pro-Leu / Ile-Arg-NH2。还公开了活性抑素类似物，前药，包括肽，融合肽和多聚体肽，包括肽序列，药物组合物，包括激活素及其类似物，前药，其融合和多聚肽，编码激酶和其类似物的核酸，以及编码融合和多聚体肽。抗癌药及其类似物（包括前体药物和多聚体和/或融合肽）可用于治疗和/或预防与缓激肽相关的疾病，包括心血管疾病，炎症，哮喘，过敏性鼻炎，疼痛，血管发生等。

4. 发明申请

WO2008149115A1 PRECURSOR OF TRYPTOPHYLLIN-1 AND USES THEREOF 审中-公开
标题翻译：三苯乙烯-1的前体及其用途
公开(公告)号：WO2008149115A1
公开(公告)日：2008-12-11
申请号：PCT/GB2008/001961
申请日：2008-06-06
申请人： THE QUEEN'S UNIVERSITY OF BELFAST , SHAW, Christopher , CHEN, Tianbao , O'ROURKE, Martin , WALKER, Brian , HIRST, David
发明人： SHAW, Christopher , CHEN, Tianbao , O'ROURKE, Martin , WALKER, Brian , HIRST, David
IPC分类号： A61K38/08 , C07K7/06 , A61P9/00
CPC分类号： A61K38/08 , C07K7/06
摘要： Described is a peptide QUB919, having sequence Lys-Pro-Pro-Pro-Trp-Val-Pro-Val (SEQ ID NO: 1), and fragments or analogues thereof, including reverse peptides thereof, and their novel use as bradykinin receptor antagonists and as anti-angiogenic agents.
摘要翻译：描述了具有序列Lys-Pro-Pro-Pro-Trp-Val-Pro-Val（SEQ ID NO：1）的肽QUB919及其包含其逆肽的片段或类似物及其作为缓激肽受体拮抗剂的新用途和作为抗血管生成剂。

5. 发明申请

WO2008107722A2 PEPTIDES, COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：肽，组合物及其用途
公开(公告)号：WO2008107722A2
公开(公告)日：2008-09-12
申请号：PCT/GB2008/050163
申请日：2008-03-07
申请人： THE QUEEN'S UNIVERSITY OF BELFAST , SHAW, Christopher , CHEN, Tianbao , O'ROURKE, Martin , WALKER, Brian , HIRST, David
发明人： SHAW, Christopher , CHEN, Tianbao , O'ROURKE, Martin , WALKER, Brian , HIRST, David
IPC分类号： C07K14/43
CPC分类号： C07K7/18 , C07K14/47
摘要： Described is an N-terminal hexapeptide fragment of maximakinin, QUB 698.8, which exhibits potent tissue selective actions on smooth muscle. It demonstrates a high degree of selectivity for arterial smooth muscle over small intestinal smooth muscle, causing potent relaxation of arterial smooth muscle, while causing less potent contraction of ileal smooth muscle. It may be used treatment of diseases of the cardiovascular system and in promotion of angiogenesis.
摘要翻译：描述的是最大蛋白质的N末端六肽片段，QUB 698.8，其在平滑肌上表现出有力的组织选择性作用。它表现出对小肠平滑肌的动脉平滑肌的高度选择性，导致动脉平滑肌的强力松弛，同时引起回肠平滑肌的较不有效的收缩。它可用于治疗心血管系统疾病和促进血管生成。

6. 发明申请

WO2009053725A2 PEPTIDES AND USES THEREOF 审中-公开
标题翻译：肽及其用途
公开(公告)号：WO2009053725A2
公开(公告)日：2009-04-30
申请号：PCT/GB2008/003637
申请日：2008-10-27
申请人： THE QUEEN'S UNIVERSITY OF BELFAST , KING'S COLLEGE LONDON , SHAW, Christopher , JONES, Peter , PERSAUD, Shanta , CHEN, Tianbao , WALKER, Brian
发明人： SHAW, Christopher , JONES, Peter , PERSAUD, Shanta , CHEN, Tianbao , WALKER, Brian
IPC分类号： A61K38/22 , A61P3/00
CPC分类号： A61K31/7004 , A61K38/00 , C07K14/575 , A61K2300/00
摘要： The invention relates to fragments of Chromogranin A (CgA) derived peptide fragments and their use in methods of therapy, for example in the treatment of diabetes etc. The peptides, for example AL-11, GV-19 and WE-14, are tropic, i.e stimulate release of regulatory substances and may be used in the absence of a stimulatory concentration of glucose.
摘要翻译：本发明涉及嗜铬粒蛋白A（CgA）衍生的肽片段的片段及其在治疗方法中的用途，例如用于治疗糖尿病等。肽例如AL-11，GV-19和WE-14是热带的，即刺激调节物质的释放，并且可以在没有葡萄糖的刺激浓度的情况下使用。

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