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1. 发明申请

WO2017161004A1 PKCδ INHIBITOR FORMULATIONS AND USES THEREOF CROSS-REFERENCE TO RELATED APPLICATIONS 审中-公开
标题翻译： PKCδ抑制剂制剂及其用途相关申请的交叉引用
公开(公告)号：WO2017161004A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/022538
申请日：2017-03-15
申请人： UNIVERSITY OF SOUTH FLORIDA , THE USA GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS OFFICE OF THE GENERAL COUNSEL - PSG IV (024)
发明人： PATEL, Niketa, A. , PATEL, Rekha, S. , SPARKS, Robert, Pleasants , GUIDA, Wayne, Charles
IPC分类号： C07D401/06
CPC分类号： A61K31/4035 , A61K31/357 , A61K31/36 , A61K31/4184 , A61K31/444 , A61K31/4965 , A61K31/517 , A61K31/519 , A61K45/06 , A61P3/04
摘要： Provided herein are formulations that can contain an effective amount of a PKCδ inhibitor. Also provided herein are methods of inhibiting a PKCδ in a subject in need thereof, that can include the step of administering an effective amount of a compound that is capable of inhibiting a PKCδ.
摘要翻译：本文提供了可含有有效量的PKCδ抑制剂的制剂。本文还提供了在有需要的受试者中抑制PKCδ的方法，其可包括施用有效量的能够抑制PKCδ的化合物的步骤。

2. 发明申请

WO2018045022A1 ADIPOSE DERIVED STEM CELL EXOSOMES AND USES THEREOF 审中-公开
标题翻译：脂肪干衍生干细胞的外体和用途
公开(公告)号：WO2018045022A1
公开(公告)日：2018-03-08
申请号：PCT/US2017/049359
申请日：2017-08-30
申请人： UNIVERSITY OF SOUTH FLORIDA , THE UNITED STATES DEPARTMENT OF VETERANS AFFAIRS
发明人： COOPER, Denise, R. , GOULD, Lisa , PATEL, Niketa, A. , WU, Mack
IPC分类号： A61K35/35 , C12N5/00 , C12N15/113
CPC分类号： A61K35/35 , A61K9/0014 , A61P17/02 , C12N5/0653 , C12N5/0667 , C12N15/113 , C12N2310/111 , C12N2310/20
摘要： Provided herein are exosomal compositions and exsosomal lncRNA compositions and formulations thereof. Also provided herein are methods of treating a wound in a subject in need thereof that can contain the step of administering an exosomal composition and/or exsosomal lncRNA compositions or formulation thereof to a wound in a subject in need thereof.
摘要翻译：本文提供了外泌体组合物和外泌体lncRNA组合物及其制剂。本文还提供治疗有需要的受试者的伤口的方法，其可包含将外泌体组合物和/或外泌体组织lncRNA组合物或其制剂给予需要其的受试者的伤口的步骤。

3. 发明申请

WO2017106505A1 GAS5 BINDING COMPOUNDS, FORMULATIONS, AND USES THEREOF 审中-公开
标题翻译： GAS5结合化合物，配方及其用途
公开(公告)号：WO2017106505A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/066937
申请日：2016-12-15
申请人： UNIVERSITY OF SOUTH FLORIDA , THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF VETERANS AFFAIRS OFFICE OF GENERAL COUNSEL-PSG IV (024)
发明人： PATEL, Niketa, A. , CAI, Jianfeng
IPC分类号： C07D285/00 , C07K14/47 , C07K14/705 , G01N33/577 , A61K31/38 , A61K31/395 , A61K38/01
CPC分类号： A61K31/395 , A61K31/4045 , A61K38/00 , A61K45/06 , C07D285/00 , A61K2300/00
摘要： Provided herein are compounds that can bind GAS5 long non-coding RNA, compositions thereof, and uses thereof.
摘要翻译：本文提供可结合GAS5长非编码RNA的化合物，其组合物及其用途。

4. 发明申请

WO2016089732A2 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND MANAGEMENT OF DIABETES AND METABOLIC SYNDROME 审中-公开
标题翻译：糖尿病和代谢综合征的诊断和治疗方法与组合
公开(公告)号：WO2016089732A2
公开(公告)日：2016-06-09
申请号：PCT/US2015/062912
申请日：2015-11-30
申请人： UNIVERSITY OF SOUTH FLORIDA , THE U. S. GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS OFFICE OF GENERAL COUNSEL
发明人： PATEL, Niketa, A.
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , G01N33/6893 , G01N2800/042
摘要： Described herein are assays, methods, and devices for diagnosing/prognosing diabetes, metabolic syndrome, pre-diabetic state and/or the early-onset of diabetes in a subject. The assays, methods, and devices described herein can be configured to detect one or more long- coding RNAs in a sample from a subject.
摘要翻译：本文描述了用于诊断/预测受试者中的糖尿病，代谢综合征，糖尿病前状态和/或糖尿病早期发作的测定，方法和装置。本文描述的测定，方法和装置可以被配置为检测来自受试者的样品中的一种或多种长编码RNA。

5. 发明申请

WO2011103308A2 METHODS OF USING HUMAN PROTEIN KINASE C DELTA VIII AS A BIOMARKER 审中-公开
标题翻译：使用人类蛋白激酶C DELTA VIII作为生物标记物的方法
公开(公告)号：WO2011103308A2
公开(公告)日：2011-08-25
申请号：PCT/US2011/025269
申请日：2011-02-17
申请人： U.S. DEPARTMENT OF VETERAN AFFAIRS , UNIVERSITY OF SOUTH FLORIDA , PATEL, Niketa, A. , COOPER, Denise, A.
发明人： PATEL, Niketa, A. , COOPER, Denise, A.
IPC分类号： G01N33/68 , C12Q1/68 , C12N15/63
CPC分类号： G01N33/57407 , G01N2333/91215 , G01N2800/28 , G01N2800/2814 , G01N2800/2821 , G01N2800/2835 , G01N2800/285
摘要： RA treatment can improve cognition; promote neurogenesis; and regulate alternative splicing of genes, particularly by mediating mechanisms of 5' splice site selection and generation of PKCδ alternatively spliced variants. Expression of PKCδVIII is an indicator of the levels of on-going apoptosis in neurons. In the aging brain, switching the isoform expression to PKCδVIII by RA could shield the cells from neuronal death. The inventors discovered that human PKCδVIII expression is increased in neuronal cancer and decreased in Alzheimer's disease. The data shows that PKCδVIII promotes neuronal survival and increases neurogenesis via Bcl2 and Bcl-xL. In addition, the trans-factor SC35 was found to be crucial in mediating the effects of RA on alternative splicing of PKCδVIII mRNA in neurons. The data described herein indicate that PKCδVIII can be used as a biomarker for neurological diseases such as cancers and Alzheimer's disease and as a tool for monitoring and evaluating treatment.
摘要翻译： RA治疗可以改善认知; 促进神经发生; 并调节基因的可变剪接，特别是通过介导5'剪接位点选择和产生PKCd可变剪接变体的机制。 PKCdVIII的表达是神经元中正在进行的凋亡水平的指标。在老化的大脑中，通过RA将同种型表达切换为PKCdVIII可以屏蔽细胞免受神经元死亡。本发明人发现，人类PKCdVIII表达在神经元癌症中增加并且在阿尔茨海默病中降低。数据显示PKCdVIII促进神经元存活并通过Bcl2和Bcl-xL增加神经发生。另外，发现转录因子SC35在介导RA对神经元中PKCdVIII mRNA的选择性剪接的作用方面至关重要。本文描述的数据表明PKCdVIII可用作神经疾病如癌症和阿尔茨海默氏病的生物标志物，并用作监测和评价治疗的工具。

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