专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

2. 发明申请

WO2003072050A2 PREVENTION OF AND THERAPY FOR RADIATION TOXICITY OF NORMAL TISSUES USING DRUGS WHICH BLOCK IL-1 ACTIVITY 审中-公开
标题翻译：使用块IL-1活性的药物对正常组织的放射性毒性进行预防和治疗
公开(公告)号：WO2003072050A2
公开(公告)日：2003-09-04
申请号：PCT/US2003/005624
申请日：2003-02-25
申请人： UNIVERSITY OF ROCHESTER MEDICAL CENTER , OKUNIEFF, Paul , DING, Ivan , CHEN, Yuhchyau
发明人： OKUNIEFF, Paul , DING, Ivan , CHEN, Yuhchyau
IPC分类号： A61K
CPC分类号： A61K38/2006 , A61K31/00 , A61K31/635 , A61K38/20
摘要： A method for the prevention of and therapy for radiation pneumonitis, dermatitis, soft tissue fibrosis and central nervous system toxicity in patients undergoing therapeutic radiation. In addition, the invention provides for pre-treatment of those responding to nuclear bio terrorism or other nuclear or radiological accidents. Thus, with the present invention, subjects may be treated in order to prevent toxicity from nuclear bio terrorism or other nuclear or radiological accidents. More particularly, we have discovered a method for prophylactically treating radiation toxicity in normal tissue of a subject comprising administering an anti-radiation toxicity effective amount of a cytokine blocking agent through the subject. More specifically, we have discovered a method for prophylactically treating radiation pneumonitis, dermatitis, soft tissue fibrosis or central nervous system toxicity in a subject comprising administering an anti-radiation pneumonitis, dermatitis, soft tissue fibrosis or central nervous system toxicity effective amount of a cytokine blocking agent to the subject.
摘要翻译：一种在接受治疗性放射治疗的患者中预防和治疗放射性肺炎，皮炎，软组织纤维化和中枢神经系统毒性的方法。此外，本发明还规定了应对核生物恐怖主义或其他核或放射性事故的人员的预处理。因此，通过本发明，可以对受试者进行治疗，以防止核生物恐怖主义或其他核或放射学事故的毒性。更具体地，我们已经发现了预防性治疗受试者正常组织中的放射线毒性的方法，其包括通过受试者施用抗辐射毒性有效量的细胞因子阻断剂。更具体地，我们已经发现一种用于预防性治疗受试者的放射性肺炎，皮炎，软组织纤维化或中枢神经系统毒性的方法，包括施用抗辐射性肺炎，皮炎，软组织纤维化或中枢神经系统毒性有效量的细胞因子阻断剂到受试者。

IPRDB

热门服务

关于我们

友情链接

联系方式