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1. 发明申请

WO2007100728A2 MANNOSE DERIVATIVES FOR KILLING TUMOR CELLS 审中-公开
标题翻译：用于杀死肿瘤细胞的MANNOSE衍生物
公开(公告)号：WO2007100728A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/004845
申请日：2007-02-26
申请人： UNIVERSITY OF MIAMI , LAMPIDIS, Theodore, J. , KURTOGLU, Metin , MATHER, John
发明人： LAMPIDIS, Theodore, J. , KURTOGLU, Metin , MATHER, John
IPC分类号： A61K31/70
CPC分类号： A61K31/70 , A61K45/06 , A61K2300/00
摘要： A method for treating cancer by killing selected tumor cells such as human breast, non-small cell lung cancer cells, pancreatic cancer cells, osteosarcoma cancer cells, and glioblastoma cells, includes administering to a patient in need of treatment, an effective amount of at least one mannose analog such as 2-DG or 2-FM or 2-CM. The killing is believed to be due to an interference with glycosylation. A theranostic method includes determining whether a patient. cancer tumor sample comprises cells sensitive to killing to at least one mannose analog due to an interference with glycosylation.
摘要翻译：通过杀死所选择的肿瘤细胞如人乳腺癌，非小细胞肺癌细胞，胰腺癌细胞，骨肉瘤癌细胞和成胶质细胞瘤细胞来治疗癌症的方法包括向需要治疗的患者施用有效量的至少一种甘露糖类似物如2-DG或2-FM或2-CM。这种杀戮被认为是由于对糖基化的干扰。鉴别方法包括确定患者是否。癌症肿瘤样品包含由于干扰糖基化而对至少一种甘露糖类似物的杀伤敏感的细胞。

2. 发明申请

WO2009143515A2 TREATMENT USING CONTINUOUS LOW DOSE APPLICATION OF SUGAR ANALOGS 审中-公开
标题翻译：使用连续低剂量蔗糖应用的处理
公开(公告)号：WO2009143515A2
公开(公告)日：2009-11-26
申请号：PCT/US2009/045157
申请日：2009-05-26
申请人： UNIVERSITY OF MIAMI , LAMPIDIS, Theodore, J. , KURTOGLU, Metin
发明人： LAMPIDIS, Theodore, J. , KURTOGLU, Metin
IPC分类号： A61K31/7004 , A61P35/00 , A61K31/702
CPC分类号： A61K31/7004 , A61K31/702
摘要： Methods and uses of low dosage nonmetabolizable D-glucose analogs and mannose analogs such as 2-deoxy-D-glucose, 5-thio-D-glucose, 2-fluoro-2-deoxy-D-glucose, 2-chloro-2-deoxy-D-glucose, 2-bromo-2-deoxy-D-glucose, 2-deoxy-2-fluoro- mannose, 2-deoxy-2-chloro-mannose, 3-deoxy mannose, 4-deoxy mannose, and 2,3 didioxy mannose, for the treatment of tumors.
摘要翻译：低剂量非代谢D-葡萄糖类似物和甘露糖类似物如2-脱氧-D-葡萄糖，5-硫代-D-葡萄糖，2-氟-2-脱氧-D-葡萄糖，2-氯-2- 脱氧-D-葡萄糖，2-溴-2-脱氧-D-葡萄糖，2-脱氧-2-氟 - 甘露糖，2-脱氧-2-氯甘露糖，3-脱氧甘露糖，4-脱氧甘露糖和2 ，3代谢甘露糖，用于治疗肿瘤。

3. 发明申请

WO2010111208A1 MITOCHONDRIAL INHIBITORS AND USES THEREOF 审中-公开
标题翻译：麻醉抑制剂及其用途
公开(公告)号：WO2010111208A1
公开(公告)日：2010-09-30
申请号：PCT/US2010/028215
申请日：2010-03-23
申请人： UNIVERSITY OF MIAMI , KURTOGLU, Metin , LAMPIDIS, Theodore, J.
发明人： KURTOGLU, Metin , LAMPIDIS, Theodore, J.
IPC分类号： C12Q1/00
CPC分类号： G01N33/5076 , G01N33/5079 , G01N33/84 , G01N2800/2821 , G01N2800/2835 , G01N2800/2878
摘要： Compositions which modulate mitochondrial functions treat diseases associated with cells that are hyperactively using their endoplasmic reticulum. Screening assays identify agents which modulate mitochondrial functions.
摘要翻译：调节线粒体功能的组合物治疗与使用其内质网过度活跃的细胞相关的疾病。筛选试验鉴定调节线粒体功能的试剂。

4. 发明申请

WO2012024234A1 COMPOSITIONS AND METHODS FOR INDUCING CANCER CELL DEATH 审中-公开
标题翻译：用于诱导癌细胞死亡的组合物和方法
公开(公告)号：WO2012024234A1
公开(公告)日：2012-02-23
申请号：PCT/US2011/047781
申请日：2011-08-15
申请人： UNIVERSITY OF MIAMI , LAMPIDIS, Theodore , KURTOGLU, Metin
发明人： LAMPIDIS, Theodore , KURTOGLU, Metin
IPC分类号： G01N33/574
CPC分类号： A61K31/7004 , A61K31/198 , A61K31/713 , A61K45/06 , A61K2300/00
摘要： Described herein are pharmaceutical compositions including a sugar or mannose analog (e.g., 2-DG) and an inhibitor of at least one of PERK and GCN2 (e.g., an inhibitor of PERK and an inhibitor of GCN2) for treating cancer, and methods of treating cancer in a subject involving administration of these pharmaceutical compositions. Pharmaceutical compositions [or inducing death of cancer cells include a therapeutically effective amount of a pharmaceutical composition including: a pharmaceutically acceptable carrier, a sugar analog in an amount effective for inhibiting the growth of cancer cells, and an inhibitor of at least one of: PERK and GCN2 in an amount effective for blocking phosphorylation of eif2-l"t in the cancer cells, wherein the combined amounts of the sugar analog and the inhibitor of at least one of: PERK and GCN2 are sufficient for inducing death of the cancer cells.
摘要翻译：本文描述了用于治疗癌症的药物组合物，包括糖或甘露糖类似物（例如2-DG）和至少一种PERK和GCN2（例如，PERK的抑制剂和GCN2抑制剂）的抑制剂，以及治疗癌症的方法涉及这些药物组合物的给药的受试者的癌症。药物组合物[或诱导癌细胞死亡包括治疗有效量的药物组合物包括：药学上可接受的载体，有效抑制癌细胞生长的糖类似物，以及以下至少一种的抑制剂：PERK 和GCN2，其量有效阻断癌细胞中eif2-1“t的磷酸化，其中糖类似物和至少一种：PERK和GCN2的抑制剂的组合量足以诱导癌细胞的死亡。

5. 发明申请

WO2016065353A1 COMBINATION THERAPY WITH FENOFIBRATE AND 2-DEOXYGLUCOSE OR 2-DEOXYMANNOSE 审中-公开
标题翻译：联合治疗与脱氧胆酸和2-脱氧葡萄糖或2-脱氧山梨醇
公开(公告)号：WO2016065353A1
公开(公告)日：2016-04-28
申请号：PCT/US2015/057333
申请日：2015-10-26
申请人： UNIVERSITY OF MIAMI
发明人： LAMPIDIS, Theodore, J. , KURTOGLU, Metin , LIU, Huaping
IPC分类号： A61K31/216 , A61K31/7004 , C07H3/08
CPC分类号： C07H3/08 , A61K31/216 , A61K31/7004 , A61K2300/00
摘要： Combination therapy comprising (1) fenofibrate and (2) 2-deoxyglucose or 2-deoxymannose is disclosed. Methods of using the combination therapy in the treatment of hyperproliferative disease including cancer and pharmaceutical compositions comprising (1) fenofibrate and (2) 2-deoxyglucose or 2-deoxymannose are also disclosed.
摘要翻译：公开了包含（1）非诺贝特和（2）2-脱氧葡萄糖或2-脱氧甘露糖的组合疗法。还公开了使用组合疗法治疗包括癌症的过度增殖性疾病和包含（1）非诺贝特和（2）2-脱氧葡萄糖或2-脱氧甘露糖的药物组合物的方法。

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