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1. 发明申请

WO2008090533A2 A BONE CEMENT 审中-公开
标题翻译：骨水泥
公开(公告)号：WO2008090533A2
公开(公告)日：2008-07-31
申请号：PCT/IE2008/000005
申请日：2008-01-25
申请人： UNIVERSITY OF LIMERICK , TOWLER, Mark, Robert , BOYD, Daniel , CLARKIN, Owen
发明人： TOWLER, Mark, Robert , BOYD, Daniel , CLARKIN, Owen
IPC分类号： A61L27/10 , A61L27/50 , C03C3/078
CPC分类号： A61L27/50 , A61L27/10 , A61L2430/02 , C03C3/078 , C03C4/0007 , C03C14/004 , C03C2214/12 , C03C2214/30
摘要： A bone cement comprises a zinc-based glass and polyalkenoate acid. In addition, the cement comprises a controlled amount of tri-sodium citrate (Na3C6HsO7) ("TSC"). The cement has enhanced rheology without negatively impacting on the mechanical properties. Controlled addition of TSC significantly improves the rheology of the bone cements, increasing working and setting times (illustrated in Fig. 1). For three formulations of the working time can be adjusted from less than 50 seconds to almost 120 seconds; concomitantly working times improve from 58 seconds to duration in excess of 300s.
摘要翻译：骨水泥包括锌基玻璃和聚烯丙酸。此外，水泥包含受控量的柠檬酸三钠（Na 3 C 6 H 6 O 7）（“TSC”）。该水泥具有增强的流变性，而不会对机械性能产生负面影响。控制添加TSC显着改善骨水泥的流变性，增加工作和凝固时间（如图1所示）。对于三种配方的工作时间可以从小于50秒调整到近120秒; 伴随工作时间从58秒提高到持续时间超过300秒。

2. 发明申请

WO2007020613A1 A SYNTHETIC GRAFT HAVING A GLASS NETWORK 审中-公开
标题翻译：具有玻璃网络的合成树脂
公开(公告)号：WO2007020613A1
公开(公告)日：2007-02-22
申请号：PCT/IE2006/000080
申请日：2006-07-31
申请人： UNIVERSITY OF LIMERICK , TOWLER, Mark, Robert , BOYD, Daniel
发明人： TOWLER, Mark, Robert , BOYD, Daniel
IPC分类号： A61L24/12 , A61K6/083 , C04B28/28 , C03C3/04
CPC分类号： C04B28/28 , A61L24/0089 , A61L24/12 , C03C3/078 , C03C4/0007 , C03C12/00 , C04B2111/00836 , C04B14/06 , C04B14/30 , C04B2103/001 , C08L33/02
摘要： A synthetic graft has a glass composition comprises silicon as a network former and Sr as a stable isotope acting as a network modifier. The composition contains calcium as a network modifier and Zn acting as a as either a network modifier or as a network former. The glass composition may be mixed with a solution of polyalkenoic acid to provide advantageous glass polyalkenoate cements (GPCs). These cements are particularly effective for use as bone cements and fillers in the human skeleton as they set at room temperature, have similar strengths to bone, chemically bond to both bone and surgical metal, and release therapeutic ions, which can assist in wound healing and bone re-growth.
摘要翻译：合成移植物具有玻璃组合物，其包含作为网络形成剂的硅和Sr作为稳定同位素作为网络改性剂。该组合物含有钙作为网络改性剂，Zn作为网络改性剂或作为网络前体。玻璃组合物可以与聚烯酸溶液混合以提供有利的玻璃聚烯丙酸酯粘结剂（GPC）。这些粘固剂在人体骨架中用作骨水泥和填料时特别有效，因为它们在室温下固化，具有与骨相似的强度，与骨和手术金属化学键合，以及释放治疗离子，其可以帮助伤口愈合和骨再生长。

3. 发明申请

WO2008104964A2 A SYNTHETIC BONE GRAFT 审中-公开
标题翻译：合成骨髓
公开(公告)号：WO2008104964A2
公开(公告)日：2008-09-04
申请号：PCT/IE2008/000016
申请日：2008-02-26
申请人： UNIVERSITY OF LIMERICK , BOYD, Daniel , TOWLER, Mark, Robert
发明人： BOYD, Daniel , TOWLER, Mark, Robert
IPC分类号： A61K6/083 , A61L24/12 , C03C3/04
CPC分类号： A61L24/12 , A61L27/10 , A61L2430/02 , C03C3/062 , C03C4/0007
摘要： A particulate glass for a synthetic bone (including dental) graft includes ZnO, SrO, and may include NaO. The glass promotes cellular metabolism, and upon implantation in living bone tissue induces bone growth at their surface. The ZnO and SrO respectively degrade to provide Zn 2+ and Sr 2+ ions respectively. The ions released by the glass provide anti-bacterial effects; improved bone formation in place of diseased tissue; inhibition of bone resorption; and radiopacity. There is excellent synergy between the SrO, ZnO, and NaO. The Sr 2+ ions have better bone formation effects than the Zn 2+ ions, but an anti-bacterial effect which is not as good. Choice of relative proportions of ZnO and SrO combined with the choice of NaO concentration to set the resorption rate allow optimisation. NaO there is control of the degradation rate of the graft; a feature which is advantageous in tailoring the grafts to specific patients and applications. Additionally the sodium (Na) in the glass imparts water solubility, allowing glasses to degrade to their ionic components.
摘要翻译：用于合成骨（包括牙科）移植物的颗粒状玻璃包括ZnO，SrO，并且可以包括NaO。玻璃促进细胞代谢，并且植入活体骨组织后，在其表面诱导骨生长。 ZnO和SrO分别降解以分别提供Zn 2+和Sr 2+ 2+。由玻璃释放的离子提供抗菌作用; 改善骨形成代替病变组织; 抑制骨吸收; 和不透射线。 SrO，ZnO和NaO之间具有良好的协同作用。 Sr 2+离子具有比Zn 2+ 2+离子更好的骨形成效果，但是抗菌效果不如那么好。选择ZnO和SrO的相对比例结合选择NaO浓度来设定吸收速率允许优化。 NaO有控制移植物的降解速率; 这有利于将移植物定制到特定患者和应用中。此外，玻璃中的钠（Na）赋予水溶性，允许玻璃降解成其离子组分。

4. 发明申请

WO2011121087A1 A GLASS CERAMIC BIOMATERIAL 审中-公开
标题翻译：玻璃陶瓷生物材料
公开(公告)号：WO2011121087A1
公开(公告)日：2011-10-06
申请号：PCT/EP2011/055039
申请日：2011-03-31
申请人： CORK INSTITUTE OF TECHNOLOGY , BOYD, Daniel , LOONEY, Mark
发明人： BOYD, Daniel , LOONEY, Mark
IPC分类号： A61L27/10 , A61L27/58 , C03C10/00
CPC分类号： A61L27/10 , A61L27/56 , A61L27/58 , A61L2430/02 , C03C3/062 , C03C3/078 , C03C4/0007 , C03C10/0009
摘要： A glass ceramic biomaterial (1) comprises SrO, ZnO, CaO, SiO 2 and Na 2 O. The biomaterial (1) has a crystalline atomic structure. The biomaterial (1) is provided in the form of a porous foam. The biomaterial (1) with the crystalline atomic structure is degradable for release of bio active Sr 2+ ions and for release of bio active Zn 2+ ions. The Sr 2+ ions may assist with bone regeneration, and the Zn 2+ ions may provide an anti-bacterial function.
摘要翻译：玻璃陶瓷生物材料（1）包括SrO，ZnO，CaO，SiO2和Na2O。生物材料（1）具有结晶原子结构。生物材料（1）以多孔泡沫的形式提供。具有结晶原子结构的生物材料（1）可降解以释放生物活性Sr 2+离子并释放生物活性Zn 2+离子。 Sr2 +离子可有助于骨再生，Zn2 +离子可提供抗细菌功能。

5. 发明申请

WO2012101524A2 RADIOPAQUE EMBOLIC PARTICLES 审中-公开
标题翻译：放射性胶囊
公开(公告)号：WO2012101524A2
公开(公告)日：2012-08-02
申请号：PCT/IB2012/000341
申请日：2012-01-27
申请人： DALHOUSIE UNIVERSITY , ABRAHAM, Robert, J. , KEHOE, Sharon , BOYD, Daniel
发明人： ABRAHAM, Robert, J. , KEHOE, Sharon , BOYD, Daniel
IPC分类号： C01B7/00
CPC分类号： A61K49/08 , A61K9/143 , A61K33/00 , A61K33/08 , A61K33/24 , A61K49/0419 , A61K2300/00
摘要： A radiopaque particulate material one or more of SiO 2 , TiO 2 , La 2 O 3 , Na 2 O and MgO and useful for embolization which optionally includes therapeutic components that are released in vivo .
摘要翻译：不透射线的颗粒材料，一种或多种SiO 2，TiO 2，La 2 O 3，Na 2 O和MgO，并且可用于栓塞，其任选地包括在体内释放的治疗成分。

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