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    • 7. 发明申请
    • SILICA-BASED ANTIBACTERIAL AND ANTIFUNGAL NANOFORMULATION
    • 基于二氧化硅的抗菌和抗真菌纳米抗体
    • WO2010068275A1
    • 2010-06-17
    • PCT/US2009/006496
    • 2009-12-10
    • UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.SANTRA, Swadeshmukul
    • SANTRA, Swadeshmukul
    • A61K31/44A61K9/14
    • A01N25/32A01N59/20A61K9/5115A61K33/34Y10S977/778A01N25/04A01N2300/00
    • A silica-based nanoformulation and method is used to treat citrus canker, inhibit the growth of mold and mildew, and add nutrients to soil used for agricultural purposes. The nanotechnology-enabled copper-loaded, silica nanoformulation (CuSiNP/NG) design is a "revolutionary re-invention" of Cu for safe applications in a formulation with a maximum abundance of ionic Cu, sustained and optimal Cu ion release for long-term disease protection, better adherence to plant and structural surfaces. The gel-based nanostructure of CuSiNG eliminates multiple spray applications and reduces the amount of Cu used, without compromising antibacterial activity, in comparison to existing Cu compounds. The gel- based nanostructure of Cu loaded silica nanogel (CuSiNG) has improved Cu bioavailability, expansive plant surface coverage and longevity of coverage with the incorporation of silane precursor compounds. The incorporation of ruthenium based fluorescent dyes into CuSiNG provides a means for monitoring adherence properties and detecting when reapplication of CuSiNG is warranted.
    • 使用二氧化硅基纳米制剂和方法治疗柑橘溃疡,抑制霉菌和霉菌的生长,并为农业用途的土壤添加营养。 纳米技术的铜负载,二氧化硅纳米制剂(CuSiNP / NG)设计是Cu的“革命性重新发明”,用于在具有最大丰度的离子Cu,长期持续和最佳Cu离子释放的配方中的安全应用 疾病保护,更好地遵守植物和结构表面。 与现有的Cu化合物相比,CuSiNG的基于凝胶的纳米结构消除了多次喷涂应用并减少了使用的Cu量,而不损害抗菌活性。 Cu负载二氧化硅纳米凝胶(CuSiNG)的基于凝胶的纳米结构改善了铜的生物利用度,膨胀的植物表面覆盖率和覆盖的寿命,同时引入硅烷前体化合物。 将钌基荧光染料掺入CuSiNG提供了一种监测粘附性能并检测何时需要重新应用CuSiNG的方法。