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    • 3. 发明申请
    • PHARMACEUTICAL COMPOSITION COMPRISING APOLIPOPROTEINS FOR THE TREATMENT OF HUMAN DISEASES
    • 包含APOLIPOPROTEIN治疗人类疾病的药物组合物
    • WO2007138023A1
    • 2007-12-06
    • PCT/EP2007/055128
    • 2007-05-25
    • UNIVERSITE LIBRE DE BRUXELLESPAYS, EtienneVANHOLLEBEKE, Benoit
    • PAYS, EtienneVANHOLLEBEKE, Benoit
    • A61K38/17A61P35/00
    • A61K38/17
    • The present invention is related to a pharmaceutical composition comprising an adequate pharmaceutical carrier or diluent and an element selected from the group consisting of a pharmaceutical composition comprising an adequate pharmaceutical carrier or diluent and an element selected from the group consisting of : - apolipoprotein apoL-III; - a pharmaceutically active fragment of this apolipoprotein apoL-III; - a nucleotide sequence encoding this apolipoprotein apoL-III or said fragment; - a vector comprising said nucleotide sequence; - a cell transformed by said nucleotide sequence or said vector; - an inhibitor or activator directed against said apolipoprotein apoL-III, its fragment or its nucleotide sequence, - an anti-inhibitor or anti-activator directed against said inhibitor or activator or its encoding nucleotide sequence.
    • 本发明涉及包含足够的药物载体或稀释剂和选自包含足够的药物载体或稀释剂的药物组合物和选自以下的元素的元素的药物组合物: - 载脂蛋白载体-III ; - 该载脂蛋白apoL-III的药物活性片段; - 编码该载脂蛋白apoL-III或所述片段的核苷酸序列; - 包含所述核苷酸序列的载体; - 由所述核苷酸序列或所述载体转化的细胞; - 针对所述载脂蛋白apoL-III,其片段或其核苷酸序列的抑制剂或激活剂 - 针对所述抑制剂或活化剂或其编码核苷酸序列的抗抑制剂或抗激活剂。