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2. 发明申请

WO2011144761A1 COMPOSITIONS FOR USE IN TREATING OR DIAGNOSING BONE DISORDERS AND/OR CARDIOVASCULAR DISORDERS 审中-公开
标题翻译：用于治疗或诊断骨质疏松症和/或心血管疾病的组合物
公开(公告)号：WO2011144761A1
公开(公告)日：2011-11-24
申请号：PCT/EP2011/058379
申请日：2011-05-23
申请人： UNIVERSITÄT FÜR BODENKULTUR WIEN , GRILLARI, Johannes , SCHRAML, Elisabeth , FORTSCHEGGER, Klaus , GRILLARI, Regina
发明人： GRILLARI, Johannes , SCHRAML, Elisabeth , FORTSCHEGGER, Klaus , GRILLARI, Regina
IPC分类号： C12N15/113 , A61K31/7088 , C12Q1/68 , A61P19/08 , A61P9/00
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7105 , C12N15/1138 , C12N2310/113 , C12N2310/141 , C12Q1/6881
摘要： The present invention relates to compositions comprising an inhibitor of a polynucleotide, said polynucleotide to be inhibited being capable of decreasing or suppressing expression of FZD3 (Frizzled-3) or a biologically active derivative thereof for use in treating or preventing bone disorders and/or cardiovascular disorders. Such bone disorders comprise, inter alia , osteoporosis, osteopenia, bone fracture, bone cancer, as well as impaired bone homeostasis. Cardiovascular diseases to be treated by the compounds of the present invention may be selected from the group consisting of infarction, stroke, hypertension, thrombosis, vascular stenosis, coronary syndromes, vascular dementia, heart failure, renal failure, stress-related cardiovascular disorders and atherosclerosis. Preferred compounds to be used in these medical interventions are antagonistic compounds, like nucleic acid molecules, directed against miR- 31 and derivatives thereof. Also, the present invention relates to methods for diagnosing and compositions for use in diagnosing bone disorders and/or cardiovascular disorders. Compounds to be employed in these diagnostic methods and uses may be compounds (like primers and probes) that are capable of detecting such a polynucleotide that is capable of decreasing or suppressing expression of FZD3 or a biologically active derivative thereof. miR-31 is provided herein as a polynucleotide that is capable of decreasing or suppressing expression of FZD3.
摘要翻译：本发明涉及包含多核苷酸抑制剂的组合物，所述待抑制的多核苷酸能够降低或抑制用于治疗或预防骨病和/或心血管疾病的FZD3（卷曲3）或其生物活性衍生物的表达障碍。这种骨骼疾病尤其包括骨质疏松症，骨质减少症，骨折，骨癌以及受损的骨平衡。本发明化合物治疗的心血管疾病可以选自梗死，中风，高血压，血栓形成，血管狭窄，冠状动脉综合征，血管性痴呆，心力衰竭，肾衰竭，应激相关心血管疾病和动脉粥样硬化。在这些医学干预中使用的优选化合物是针对miR-31及其衍生物的拮抗化合物，如核酸分子。此外，本发明还涉及用于诊断骨骼疾病和/或心血管疾病的诊断方法和组合物。用于这些诊断方法和用途的化合物可以是能够检测能够降低或抑制FZD3或其生物活性衍生物的表达的多核苷酸的化合物（如引物和探针）。本文提供miR-31作为能够降低或抑制FZD3表达的多核苷酸。

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