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1. 发明申请

WO2006006195A1 ANTIBACTERIAL PEPTIDES AND ANALOGUES THEREOF 审中-公开
标题翻译：抗菌肽及其类似物
公开(公告)号：WO2006006195A1
公开(公告)日：2006-01-19
申请号：PCT/IT2005/000397
申请日：2005-07-13
申请人： UNIVERSITÀ DEGLI STUDI DI SIENA , BRACCI, Luisa , GIULIANI, Andrea , PINI, Alessandro , NERI, Paolo
发明人： BRACCI, Luisa , GIULIANI, Andrea , PINI, Alessandro , NERI, Paolo
IPC分类号： C07K7/06
CPC分类号： A01N37/46 , A61K8/64 , A61Q17/005 , C07K7/06
摘要： Antibacterial peptides and their multimeric analogues, with a wide range of action and low haemolytic activity are described. In particular, the peptide molecules exhibit a high antimicrobial activity against numerous bacterial species, with reduced cytotoxicity and a low haemolysis rate. The molecules of the invention are advantageously usable as therapeutic agents and coadjutants against infections caused by strains that are resistant to common antibiotics.
摘要翻译：描述了具有广泛作用和低溶血活性的抗菌肽及其多聚类似物。具体而言，肽分子表现出对许多细菌物种的高抗微生物活性，具有降低的细胞毒性和低溶血率。本发明的分子有利地可用作针对抗普通抗生素的菌株引起的感染的治疗剂和辅助剂。

2. 发明申请

WO2007093373A2 BRANCHED MULTIMERIC PEPTIDES FOR TUMOR DIAGNOSIS AND THERAPY 审中-公开
标题翻译：分支多用于肿瘤诊断和治疗的多肽
公开(公告)号：WO2007093373A2
公开(公告)日：2007-08-23
申请号：PCT/EP2007/001224
申请日：2007-02-13
申请人： UNIVERSITÀ DEGLI STUDI DI SIENA , BRACCI, Luisa , FALCIANI, Chiara , PINI, Alessandro , FABBRINI, Monica
发明人： BRACCI, Luisa , FALCIANI, Chiara , PINI, Alessandro , FABBRINI, Monica
CPC分类号： C07K7/083 , C07K7/23
摘要： The instant invention refers to in vivo stable branched peptides, in particular derived from the sequence of Neurotensin (NT) and Luteinizing hormone-releasing hormone (LHRH), conjugated to functional units for specific targeting of cancer cells, either for tumor diagnosis or therapy.
摘要翻译：本发明涉及体内稳定的支链肽，特别是衍生自与用于肿瘤诊断或治疗的特异性靶向癌细胞的功能单位的神经变性蛋白（NT）和促黄体激素释放激素（LHRH）的序列。

3. 发明申请

WO2010038220A1 Peptide sequences, their branched form and use thereof for antimicrobial applications 审中-公开
标题翻译：肽序列，其分支形式及其用于抗微生物应用
公开(公告)号：WO2010038220A1
公开(公告)日：2010-04-08
申请号：PCT/IB2009/054347
申请日：2009-10-05
申请人： Università degli Studi di Siena , BRACCI, Luisa , FALCIANI, Chiara , PINI, Alessandro
发明人： BRACCI, Luisa , FALCIANI, Chiara , PINI, Alessandro
IPC分类号： A61K38/08 , C07K7/06
CPC分类号： C07K7/06 , A61K38/00
摘要： The present invention relates to an antibacterial peptide having from the amino to the carboxylic terminal an amino acid sequences selected from the group of: KKIRVRLSA, SEQ ID NO. 1, RRIRVRLSA, SEQ ID NO. 2, KRIRVRLSA, SEQ ID NO. 3, RKIRVRLSA, SEQ ID NO. 4or a derivative thereof and uses thereof.
摘要翻译：本发明涉及一种抗菌肽，其具有从氨基至羧基末端的氨基酸序列，所述氨基酸序列选自：KKIRVRLSA，SEQ ID NO： 1，RRIRVRLSA，SEQ ID NO： 2，KRIRVRLSA，SEQ ID NO： 3，RKIRVRLSA，SEQ ID NO： 4或其衍生物及其用途。

4. 发明申请

WO2003025001A1 MULTIPLE ANTIGEN PEPTIDES (MAP) AS ANTIDOTES AGAINST SNAKE NEUROTOXIN INTOXICATION 审中-公开
标题翻译：多抗抗原肽（MAP）作为抗SNAKE神经毒素毒素的抗体
公开(公告)号：WO2003025001A1
公开(公告)日：2003-03-27
申请号：PCT/IT2002/000580
申请日：2002-09-12
申请人： UNIVERSITA' DEGLI STUDI DI SIENA , BRACCI, Luisa , LOZZI, Luisa , LELLI, Barbara , PINI, Alessandro , NERI, Paolo
发明人： BRACCI, Luisa , LOZZI, Luisa , LELLI, Barbara , PINI, Alessandro , NERI, Paolo
IPC分类号： C07K14/00
CPC分类号： C07K7/08 , A61K38/00 , C07K14/001 , C07K14/70571
摘要： A Multiple Antigen Peptide comprising: a) a dendritic core basically constituted by at least one bifunctional molecule; b) at least two peptide molecules able to bind snake alphneurotoxins when injected into mammals and neutralize snake neurotoxins toxicity; wherein the dendritic core and peptide molecules are linked by covalent bonds.
摘要翻译：多抗原肽，其包含：a）基本上由至少一个双功能分子构成的树突状核; b）当注射到哺乳动物中时，至少有两种肽分子能够结合蛇形神经毒素并中和蛇神经毒素的毒性; 其中树突核心和肽分子通过共价键连接。

5. 发明申请

WO2005095444A2 SYNTHETIC PEPTIDES AS ANTIDOTES FOR ANTHRAX TOXIN 审中-公开
标题翻译：合成肽作为ANTHRAX TOXIN的抗体
公开(公告)号：WO2005095444A2
公开(公告)日：2005-10-13
申请号：PCT/IT2005/000168
申请日：2005-03-25
申请人： UNIVERSITÀ DEGLI STUDI DE SIENA , NERI, Paolo , BRACCI, Luisa , PINI, Alessandro
发明人： NERI, Paolo , BRACCI, Luisa , PINI, Alessandro
IPC分类号： C07K7/08
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06
摘要： Specific inhibitors, in Multiple Antigen Peptide form, which inhibit the interaction between protective antigen and lethal factor and neutralize anthrax toxin in vivo. Anti protective antigen peptides were selected from a phage library by competitive panning with lethal factor. Selected 12mer peptides were synthesized in tetra-branched form and systematically modified to achieve peptides with higher affinity and inhibitory efficiency.
摘要翻译：多重抗原肽形式的特异性抑制剂抑制保护性抗原与致死因子之间的相互作用并在体内中和炭疽毒素。通过与致死因子的竞争性淘选，从噬菌体文库中选择抗保护性抗原肽。选择的12mer肽以四分支形式合成并进行系统修饰以实现具有更高亲和力和抑制效率的肽。

6. 发明申请

WO2015055597A1 ANTI TNF-ALPHA COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：抗TNF-ALPHA化合物及其用途
公开(公告)号：WO2015055597A1
公开(公告)日：2015-04-23
申请号：PCT/EP2014/071924
申请日：2014-10-13
申请人： UNIVERSITÀ DEGLI STUDI DI SIENA
发明人： PINI, Alessandro , BRACCI, Luisa
IPC分类号： A61K38/10 , A61P29/00
CPC分类号： A61K38/10
摘要： The present invention refers to a peptide, multimeric derivatives thereof, pharmaceutical composition thereof and their use in therapy, in particular for inhibiting TNF-alpha activity.
摘要翻译：本发明涉及其肽，多聚体衍生物，其药物组合物及其在治疗中的用途，特别是用于抑制TNF-α活性。

7. 发明申请

WO2012010266A1 ANTIMICROBIAL PEPTIDE, BRANCHED FORMS THEREOF AND THEIR USE IN THE TREATMENT OF BACTERIA INFECTIONS 审中-公开
标题翻译：抗生素肽，其分支形式及其在治疗细菌感染中的应用
公开(公告)号：WO2012010266A1
公开(公告)日：2012-01-26
申请号：PCT/EP2011/003446
申请日：2011-07-11
申请人： SETLANCE S.r.l. , PINI, Alessandro , FALCIANI, Chiara , BRACCI, Luisa
发明人： PINI, Alessandro , FALCIANI, Chiara , BRACCI, Luisa
IPC分类号： A23L1/30 , A61K38/04 , A61L2/00 , C07K7/06
CPC分类号： C07K17/10 , A23L3/3526 , A61K38/00 , C07K7/06 , C07K17/02 , C07K17/08 , C11D3/38 , C11D3/48
摘要： The instant invention refers to an antibacterial peptide with all aminoacids in D-configuration, possessing strong antimicrobial activity against Gram-negative and Gram-positive bacteria and Candida strains. The peptide can be in linear form or multimerised on a skeleton of polyacrylamide, of dextrane units or on a skeleton of ethylene glycol units. The peptide is resistant to proteolysis especially when synthesized in the tetra-branched form where identical peptide sequences are linked together by an appropriate molecular scaffold.
摘要翻译：本发明是指具有D-构型中所有氨基酸的抗菌肽，对革兰氏阴性和革兰氏阳性菌和假丝酵母菌株具有很强的抗微生物活性。肽可以是线性形式或多聚化在聚丙烯酰胺，葡聚糖单元的骨架上或在乙二醇单元的骨架上。该肽对蛋白水解具有抗性，特别是当以相同的肽序列通过合适的分子支架连接在一起的四支化形式合成时。

8. 发明申请

WO2010052243A2 NEUROTENSIN-DERIVED BRANCHED PEPTIDES AND USES THEREOF 审中-公开
标题翻译：神经降压素衍生的多肽及其用途
公开(公告)号：WO2010052243A2
公开(公告)日：2010-05-14
申请号：PCT/EP2009/064619
申请日：2009-11-04
申请人： BRACCI, Luisa , PINI, Alessandro , FALCIANI, Chiara , MENICHETTI, Stefano
发明人： BRACCI, Luisa , PINI, Alessandro , FALCIANI, Chiara , MENICHETTI, Stefano
IPC分类号： A61K47/48
CPC分类号： C07K7/083 , A61K38/00 , A61K47/641 , A61K49/0002 , A61K49/0043 , A61K49/0056 , G01N33/574
摘要： The present invention relates to a multimeric molecule having the general formula (A) or (B): and its use in the diagnosis and/or therapy of tumors.
摘要翻译：本发明涉及具有通式（A）或（B）的多聚体分子：及其在肿瘤的诊断和/或治疗中的用途。

9. 发明申请

WO2012014046A2 SUPRAMOLECULAR AGGREGATES AS DRUG CARRIERS ON CELL EXPRESSING RECEPTORS FOR BRANCHED NEUROTENSIN 审中-公开
标题翻译：超分子聚合物作为药物载体在细胞表达分支神经递质受体
公开(公告)号：WO2012014046A2
公开(公告)日：2012-02-02
申请号：PCT/IB2011/001731
申请日：2011-07-27
申请人： TESAURO, Diego , ACCARDO, Antonella , MORELLI, Giancarlo , PEDONE, Carlo , FALCIANI, Chiara , PINI, Alessandro , BRACCI, Luisa
发明人： TESAURO, Diego , ACCARDO, Antonella , MORELLI, Giancarlo , PEDONE, Carlo , FALCIANI, Chiara , PINI, Alessandro , BRACCI, Luisa
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： A61K47/543 , A61K47/60
摘要： The present invention relates to supramolecular aggregates (liposomes, vesicles, or micelles) for target selective drug delivery; more specifically it relates to supramolecular aggregates derivatized with Neurotensin peptide in a branched form and filled, in their inner compartment or in the phospholipid bilayer, with a pharmaceutical active principle such as a cytotoxic chemotherapeutic drug. The aggregates are selectively driven by the exposed branched bioactive peptides to specific receptors overexpressed in malignant cells.
摘要翻译：本发明涉及用于靶选择性药物递送的超分子聚集体（脂质体，囊泡或胶束）更具体地涉及用分支形式的神经降压素肽衍生的超分子聚集体，并且在其内部隔室或磷脂双层中填充药物活性成分如细胞毒性化学治疗药物。聚集体被暴露的分支生物活性肽选择性地驱动到恶性细胞中过表达的特异性受体。

10. 发明申请

WO2013098799A1 A METHOD AND AN APPARATUS FOR LIGHTING AN AREA INTENDED FOR STAY AND/OR THE MOVEMENT OF PERSONS AND VEHICLES, IN PARTICULAR ROAD TUNNELS 审中-公开
标题翻译：一种用于照亮在特定道路隧道内驻留和/或运动人员和车辆的区域的方法和装置
公开(公告)号：WO2013098799A1
公开(公告)日：2013-07-04
申请号：PCT/IB2012/057847
申请日：2012-12-31
申请人： BECCHETTI, Romolo , PINI, Alessandro , VIVALDI, Francesco
发明人： BECCHETTI, Romolo , PINI, Alessandro , VIVALDI, Francesco
IPC分类号： C09D5/22
CPC分类号： C09D5/22
摘要： A method for lighting with a predetermined illuminance an environment (11,12) intended for the stay and/or for the passage of people and/or vehicles, comprising steps of selecting and installing in the environment (11,12) at least one passive lighting element (13) comprising a photoluminescent pigment, typically a material of formula Al x Sr y Ca (1-y) O z :Eu,Dy and/or an Europium and/or Dysprosium-doped alkaline-earth aluminate, in particular a material of formula SrAl 2 O 4 :Eu,Dy or SrAl 2 O 4 :Eu,Dy,B, adapted to emit a photoluminescent light flux (13') when exposed to a primary light flux (19'). In an aspect of the invention, the environment (11,12) has at least one electrically suppliable active lighting body (19) or a pre-existing electric lighting installation, which is adapted to generate the primary light flux (19'), and the method provides supplying an adjusted electric power to at least one active lighting body (19) to generate the primary light flux (19') that is summed to the photoluminescent flux (13'), producing the required illuminance. According to another aspect of the invention, the method provides steps of selecting the at least one active lighting body (19) in such a way that, by supplying it with a predetermined electric power, the primary light flux (19') and the luminescent light flux (13') produce together the required illuminance value. The method remarkably reduces the lighting energy consumptions as well as the costs of the lighting installation. In an exemplary embodiment, the environment is a road or motorway environment (11,12), for example a or pedestrian road tunnel (11). The passive lighting element (13) can be a photoluminescent stripe (13) arranged on the wall (10, 10') and parallel to the ground (9), having a predetermined width (H),
摘要翻译：一种用于以预定照度照明用于停留和/或人和/或车辆通过的环境（11,12）的方法，包括以下步骤：在环境中选择和安装（11,12）至少一个被动发光元件（13），其包含光致发光颜料，通常为AlxSryCa（1-y）Oz：Eu，Dy和/或铕和/或掺杂镝的碱土金属铝的材料，特别是式SrAl 2 O 4的材料： Eu，Dy或SrAl 2 O 4：Eu，Dy，B，当暴露于初级光通量（19'）时适于发射光致发光光通量（13'）。在本发明的一个方面，环境（11,12）具有至少一个可供电的有源发光体（19）或预先存在的电照明装置，其适于产生主光通量（19'），以及所述方法提供向至少一个有源发光体（19）提供调整的电力以产生与光致发光通量（13'）相加的一次光束（19'），从而产生所需的照度。根据本发明的另一方面，所述方法提供了以下方式选择所述至少一个有源发光体（19）的步骤：通过向所述至少一个有源发光体（19）提供预定的电力，所述主光通量（19'）和所述发光光通量（13'）一起产生所需的照度值。该方法显着降低了照明能源消耗以及照明设备的成本。在示例性实施例中，环境是道路或高速公路环境（11,12），例如道路或行人道路隧道（11）。无源发光元件（13）可以是布置在壁（10,10'）上并平行于地面（9）的具有预定宽度（H）的光致发光条纹（13）

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