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1. 发明申请

WO0183554A3 ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：抗炎化合物及其用途
公开(公告)号：WO0183554A3
公开(公告)日：2002-08-01
申请号：PCT/US0114346
申请日：2001-05-02
申请人： PRAECIS PHARM INC , UNIV YALE , MAY MICHAEL J , GHOSH SANKAR , FINDEIS MARK A , PHILLIPS KATHRYN
发明人： MAY MICHAEL J , GHOSH SANKAR , FINDEIS MARK A , PHILLIPS KATHRYN
IPC分类号： A61K38/00 , A61P1/04 , A61P7/02 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/02 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/06 , A61P31/08 , A61P31/12 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K7/06 , C07K7/08 , C07K14/47 , C12N9/12 , C12N15/09 , C12Q1/02 , C07K14/08 , A61K38/10 , A61K38/43
CPC分类号： C07K14/4703 , A61K38/00 , C07K14/4747 , C12N9/1205
摘要： The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF- kappa B-dependent target gene expression in a cell.
摘要翻译：本发明提供抗炎化合物，其药物组合物及其用于治疗炎症性疾病的方法。本发明还提供鉴定抗炎化合物的方法和抑制细胞中NF-κB依赖性靶基因表达的方法。

2. 发明申请

WO0183547A3 ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：抗炎化合物及其用途
公开(公告)号：WO0183547A3
公开(公告)日：2002-05-16
申请号：PCT/US0140654
申请日：2001-05-02
申请人： UNIV YALE , MAY MICHAEL J , GHOSH SANKAR
发明人： MAY MICHAEL J , GHOSH SANKAR
IPC分类号： A61K38/00 , A61P1/04 , A61P7/02 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/02 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/06 , A61P31/08 , A61P31/12 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K7/06 , C07K7/08 , C07K14/47 , C12N9/12 , C12N15/09 , C12Q1/02 , A61K38/16 , C12N15/12
CPC分类号： C07K14/4703 , A61K38/00 , C07K14/4747 , C12N9/1205
摘要： The present invention provides anti-inflammatory compounds, comprising at least one NEMO binding domain, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF- kappa B-dependent target gene expression in a cell.
摘要翻译：本发明提供了包含至少一个NEMO结合结构域的抗炎化合物，其药物组合物及其用于治疗炎症性疾病的方法。本发明还提供鉴定抗炎化合物的方法和抑制细胞中NF-κB依赖性靶基因表达的方法。

3. 发明申请

WO2009134544A4 DOWNHOLE BARRIER VALVE 审中-公开
标题翻译：井下阀门
公开(公告)号：WO2009134544A4
公开(公告)日：2010-04-15
申请号：PCT/US2009037622
申请日：2009-03-19
申请人： BAKER HUGHES INC , BEALL CLIFFORD H , MAY MICHAEL J , SLOAN JAMES T , HAYNES ANDREW , ANDREWS THAD D
发明人： BEALL CLIFFORD H , MAY MICHAEL J , SLOAN JAMES T , HAYNES ANDREW , ANDREWS THAD D
IPC分类号： E21B34/06 , E21B34/08 , E21B43/12
CPC分类号： E21B34/103 , E21B2034/002
摘要： A ball type downhole barrier valve capable of bidirectional sealing features a ball rotating on its axis to open or close with control line pressure to an actuating rod piston assembly. The ball is also shiftable to a locked open position. A cage surrounds the ball and retains opposed seats to it. The cage is made from one piece and tangential holes are drilled and tapped before the piece is longitudinally split with a wire EDM cutting technique. Fasteners to rejoin the cut halves properly space them to the original one piece internal dimension. Auxiliary tools allow determination of spacing of internal components so that a desired spring preload on the seats against the ball can be achieved. Seals on the sleeves that form ball seats help prevent leakage due to ball distortion at high differential pressures when the valve is closed.
摘要翻译：一种能够双向密封的球形井下阻挡阀，其特征在于，球体在其轴线上旋转，以通过控制管线压力打开或关闭致动杆活塞组件。球也可以移动到锁定的打开位置。一个笼子围绕球并保留相对的座位。保持架由一件制成，并且在利用电火花线切割技术纵向分开之前，钻出并攻丝切向孔。紧固件重新加入切割的半部分，将它们适当地放置在原来的一块内部尺寸上。辅助工具允许确定内部部件的间距，从而可以实现座椅上抵靠球的期望弹簧预加载荷。当阀门关闭时，形成球座的套筒上的密封件有助于防止高压差时由于球变形而造成的泄漏。

4. 发明申请

WO2011019645A3 PERMANENT MAGNET LINEAR MOTOR ACTUATED SAFETY VALVE AND METHOD 审中-公开
标题翻译：永磁电机线性电动机启动安全阀及方法
公开(公告)号：WO2011019645A3
公开(公告)日：2011-06-09
申请号：PCT/US2010044858
申请日：2010-08-09
申请人： BAKER HUGHES INC , LAKE GARY , MAY MICHAEL J , RANJAN PRIYESH , MURRAY DOUGLAS , RAINONE MICHAEL , SACKETT SAMUEL , PRESLEY TALBOT
发明人： LAKE GARY , MAY MICHAEL J , RANJAN PRIYESH , MURRAY DOUGLAS , RAINONE MICHAEL , SACKETT SAMUEL , PRESLEY TALBOT
IPC分类号： E21B34/10 , E21B21/10 , E21B43/12 , F16K31/06
CPC分类号： E21B34/066 , F16K31/082 , H01F7/122
摘要： A linear motor activator for a downhole safety valve including a permanent magnet carrier; a plurality of permanent magnets mounted to the permanent magnet carrier; a coil carrier disposed in magnetic field proximity to the permanent magnet carrier; and a plurality of coils mounted to the coil carrier, one of the permanent magnet carrier and the coil carrier being movable relative to the other of the permanent magnet carrier and coil carrier, and being connected to a component of a downhole safety valve and method.
摘要翻译：一种用于井下安全阀的直线电机启动器，包括永磁体载体; 安装到永磁体载体上的多个永磁体; 设置在靠近永磁体载体的磁场中的线圈架; 以及安装在所述线圈架上的多个线圈，所述永磁体载体和所述线圈架中的一个可相对于所述永磁体载体和线圈架中的另一个移动，并连接到井下安全阀和方法的部件。

5. 发明申请

WO2009134544A3 DOWNHOLE BARRIER VALVE 审中-公开
标题翻译：卧式障碍阀
公开(公告)号：WO2009134544A3
公开(公告)日：2010-02-18
申请号：PCT/US2009037622
申请日：2009-03-19
申请人： BAKER HUGHES INC , BEALL CLIFFORD H , MAY MICHAEL J , SLOAN JAMES T , HAYNES ANDREW , ANDREWS THAD D
发明人： BEALL CLIFFORD H , MAY MICHAEL J , SLOAN JAMES T , HAYNES ANDREW , ANDREWS THAD D
IPC分类号： E21B34/06 , E21B34/08 , E21B43/12
CPC分类号： E21B34/103 , E21B2034/002
摘要： A ball type downhole barrier valve capable of bidirectional sealing features a ball rotating on its axis to open or close with control line pressure to an actuating rod piston assembly. The ball is also shiftable to a locked open position. A cage surrounds the ball and retains opposed seats to it. The cage is made from one piece and tangential holes are drilled and tapped before the piece is longitudinally split with a wire EDM cutting technique. Fasteners to rejoin the cut halves properly space them to the original one piece internal dimension. Auxiliary tools allow determination of spacing of internal components so that a desired spring preload on the seats against the ball can be achieved. Seals on the sleeves that form ball seats help prevent leakage due to ball distortion at high differential pressures when the valve is closed.
摘要翻译：能够双向密封的球型井下阻挡阀的特征在于，在其轴线上旋转的滚珠以控制线压力打开或关闭到致动杆活塞组件。球也可以移动到锁定的打开位置。一个笼子围绕着球，并保留着相对的座位。保持架由一块制成，切割孔在钻头纵向分割之前用电火花线切割技术进行钻孔和攻丝。紧固件重新加入切割半部分将其适当地放置在原始的单件内部尺寸上。辅助工具允许确定内部部件的间距，从而可以实现抵靠球的座椅上所需的弹簧预载荷。形成球座的套筒上的密封有助于防止当阀门关闭时在高压差下由于球形变形引起的泄漏。

6. 发明申请

WO2012173852A2 TUBULAR VALVING SYSTEM, BODY AND METHOD OF OPENING 审中-公开
标题翻译：管状阀门系统，身体和开放方法
公开(公告)号：WO2012173852A2
公开(公告)日：2012-12-20
申请号：PCT/US2012041240
申请日：2012-06-07
申请人： BAKER HUGHES INC , COGHILL ANTHONY S , SCHUBERT DALE W , CRASE LISA D , MYERLEY THOMAS S , MAY MICHAEL J
发明人： COGHILL ANTHONY S , SCHUBERT DALE W , CRASE LISA D , MYERLEY THOMAS S , MAY MICHAEL J
IPC分类号： E21B34/06 , E21B21/10
CPC分类号： F16K5/0605 , E21B34/06 , E21B2034/002
摘要： A valving system includes, a tubular having a seat, and a body with a bore therethrough having a surface sealably engagable with the seat, the body being rotatable relative to the tubular between at least a first position, a second position and a third position, the first position occluding flow between an inside of the tubular and the bore the second position providing fluidic communication between the inside of the tubular and the bore via at least one cavity formed in the surface and a third position providing direct fluidic communication between the inside of the tubular and the bore.
摘要翻译：阀系统包括：具有座的管状体和具有穿过其中的孔的主体，所述孔具有与座部可密封地接合的表面，所述主体可在至少第一位置，第二位置和第三位置之间相对于管状物旋转，所述第一位置在所述管状物的内部和所述孔之间阻塞流动，所述第二位置通过形成在所述表面中的至少一个空腔提供所述管状物的内部和所述孔之间的流体连通，所述第三位置提供在所述内部之间的直接流体连通管状和孔。

7. 发明申请

WO2010068484A3 DOWNHOLE DECELERATING DEVICE, SYSTEM AND METHOD 审中-公开
标题翻译：卧式减速装置，系统和方法
公开(公告)号：WO2010068484A3
公开(公告)日：2010-08-05
申请号：PCT/US2009065881
申请日：2009-11-25
申请人： BAKER HUGHES INC , MYERLEY THOMAS S , MAY MICHAEL J
发明人： MYERLEY THOMAS S , MAY MICHAEL J
IPC分类号： E21B17/07
CPC分类号： E21B17/07
摘要： Disclosed herein is a downhole decelerating device. The device includes, a body movably engagable within a downhole tubular, a mandrel longitudinally movably disposed at the body, and at least one deceleration element disposed at the body in operable communication with the mandrel such that longitudinal movement of the mandrel with respect to the body causes controlled radial movement of the at least one deceleration element to decelerate the decelerating device in relation to the downhole tubular.
摘要翻译：这里公开了一种井下减速装置。该装置包括：可移动地接合在井下管状体内的主体，纵向可移动地设置在主体处的心轴和设置在主体处的与心轴可操作连通的至少一个减速元件，使得心轴相对于身体的纵向运动引起所述至少一个减速元件的受控的径向运动，以使所述减速装置相对于所述井下管减速。

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