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1. 发明申请

WO9859234A9 METHOD AND APPARATUS FOR DETECTION OF A CONTROLLED SUBSTANCE 审中-公开
标题翻译：用于检测受控物质的方法和装置
公开(公告)号：WO9859234A9
公开(公告)日：1999-04-15
申请号：PCT/US9812974
申请日：1998-06-24
申请人： UNIV WYOMING , CARRON KEITH T , CORCORAN ROBERT C
发明人： CARRON KEITH T , CORCORAN ROBERT C
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , Y10S436/815 , Y10S436/816 , Y10S436/901 , Y10T436/14 , Y10T436/141111 , Y10T436/142222 , Y10T436/145555 , Y10T436/147777 , Y10T436/163333 , Y10T436/170769
摘要： Techniques and devices for detecting and analyzing controlled substances and the like are discussed including highly reactive sensor molecules which are coated on a spectroscopic sample surface (4) and which may chemically react with a given analyte to form a covalently bonded adduct with spectral characteristics unique to the new adduct. The techniques provide the basis of a detection system with high sensitivity and high specificity in which the surface can even be washed to remove interfering or nonreactive compounds. The sensor molecules which comprise the coating (8) may have three major components: a central molecular scaffold ("CMS"), a "tether" terminated by a surface attachment group "SAG", and a reactive functional group "RFG" which may be highly reactive towards certain classes of molecules. One or more modifiers or modifier groups "Z" which may serve to increase or decrease the reactivity of the RFG towards target analytes, or to modify the spectral characteristics of the adduct may also be included. Some sensor molecules include diazonium compounds, activated acyls, and nitrosos.
摘要翻译：讨论了用于检测和分析受控物质等的技术和装置，其包括涂覆在光谱样品表面（4）上的高反应性传感器分子，并且其可以与给定的分析物发生化学反应，以形成具有独特的光谱特性的共价键合的加合物新加入。该技术提供了具有高灵敏度和高特异性的检测系统的基础，其中表面甚至可以被洗涤以除去干扰或非反应性化合物。包含涂层（8）的传感器分子可以具有三个主要成分：中心分子支架（“CMS”），由表面附着基团“SAG”终止的“连接臂”，以及反应性官能团“RFG” 对某些类别的分子具有高反应性。还可以包括一种或多种改性剂或修饰基团“Z”，其可用于增加或降低RFG对靶分析物的反应性，或修饰加合物的光谱特征。一些传感器分子包括重氮化合物，活化的酰基和亚硝基。

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