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1. 发明申请

WO2011057078A3 COMPOSITIONS AND METHODS FOR DETECTING PLECTIN-1 AS A BIOMARKER FOR CANCER 审中-公开
标题翻译：检测PLECTIN-1作为癌症生物标志物的组合物和方法
公开(公告)号：WO2011057078A3
公开(公告)日：2011-09-22
申请号：PCT/US2010055632
申请日：2010-11-05
申请人： UNIV VIRGINIA PATENT FOUND , KELLY KIMBERLY A
发明人： KELLY KIMBERLY A
IPC分类号： G01N33/68 , G01N33/574 , G01N33/58
CPC分类号： A61K51/088 , A61K47/64 , A61K49/0002 , A61K51/0482 , A61K51/065 , C07K7/06 , C07K14/00 , G01N33/531 , G01N33/574 , G01N2333/4724
摘要： The present invention provides compositions and methods useful for diagnostic and imaging techniques for detecting and localizing the biomarker Plectin-1. The present invention provides multimeric peptide ligand complexes for targeting Plectin-1, such as the multimeric peptide ligand complex having the formula (ßAKTLLPTPGGS(PEG5000))4 KKKKDOTAßA-NH2, to which imaging agents and/or therapeutic agents can be conjugated.
摘要翻译：本发明提供了用于检测和定位生物标志物网蛋白-1的诊断和成像技术的组合物和方法。本发明提供了用于靶向网蛋白-1的多聚体肽配体复合物，例如具有式（βAKTLLPTPGGS（PEG5000））4KKKKDOTAASA-NH 2的多聚体肽配体复合物，可以与成像剂和/或治疗剂缀合。

2. 发明申请

WO2012158502A2 COMPOSITIONS AND METHODS FOR A MYCOBACTERIUM TUBERCULOSIS DRUG SUSCEPTIBILITY TEST 审中-公开
标题翻译： MYCOBACTERIUM TUBCCOSOS药物耐药性测试的组合物和方法
公开(公告)号：WO2012158502A2
公开(公告)日：2012-11-22
申请号：PCT/US2012037472
申请日：2012-05-11
申请人： UNIV VIRGINIA PATENT FOUND , HOUPT ERIC R , KELLY KIMBERLY A , PHOLWAT SUPORN
发明人： HOUPT ERIC R , KELLY KIMBERLY A , PHOLWAT SUPORN
CPC分类号： C12Q1/686 , A61K31/133 , A61K31/4409 , A61K31/496 , A61K31/506 , A61K31/7036 , C12Q1/18 , C12Q1/689 , C12Q1/701 , C12Q2600/136 , G01N2333/35
摘要： The present application discloses rapid Mycobacterium tuberculosis drug susceptibility utilizing real-time PCR of mycobacteriophage D29 DNA. One protocol involves culturing Tb isolates for 48 hours with and without drugs at critical concentrations, followed by incubation with 103 pfu/ml of D29 mycobacteriophage for 24 hours and then real-time PCR. Many drugs can be incubated instantly with Tb and phage. The change in phage DNA real-time PCR cycle threshold (Ct) between control Tb and Tb treated with drugs was calculated and correlated with conventional agar proportion drug susceptibility results. Specifically, 9 susceptible clinical isolates, 22 MDR, and 1 XDR Tb strains were used and Ct control - Ct drug cutoffs of between +0.3 and -6.0 yielded 422/429 (98%) accurate results for the drugs tested. The Ct values correlated with isolate minimal inhibitory concentration (MIC) for most agents. This D29 qPCR assay offers a rapid, accurate, 1-3 day phenotypic drug susceptibility test.
摘要翻译：本申请公开了利用分枝杆菌噬菌体D29DNA的实时PCR的快速结核分枝杆菌药物敏感性。一个方案包括在临界浓度下用和不用药物培养Tb分离物48小时，然后与103pfu / ml的D29分枝杆菌噬菌体孵育24小时，然后进行实时PCR。许多药物可以用Tb和噬菌体立即孵育。计算用药物处理的对照Tb和Tb之间的噬菌体DNA实时PCR循环阈值（Ct）的变化，并与常规琼脂比例药物敏感性结果相关。具体来说，使用了9种敏感性临床分离株，22种MDR和1种XDR Tb菌株，对于所测试的药物，Ct对照 - Ct药物截止值在+ 0.3和-6.0之间产生了422/429（98％）的准确结果。 Ct值与大多数试剂的分离最小抑制浓度（MIC）相关。这种D29 qPCR测定提供了快速，准确的1-3天表型药物敏感性测试。

3. 发明申请

WO2011150226A9 METHOD FOR DETECTING NUCLEIC ACIDS BASED ON AGGREGATE FORMATION 审中-公开
标题翻译：基于聚集形成检测核酸的方法
公开(公告)号：WO2011150226A9
公开(公告)日：2012-01-19
申请号：PCT/US2011038166
申请日：2011-05-26
申请人： LANDERS JAMES P , KELLY KIMBERLY A , LI JINGYI , LESLIE DANIEL C
发明人： LANDERS JAMES P , KELLY KIMBERLY A , LI JINGYI , LESLIE DANIEL C
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6888 , C12Q1/6816 , C12Q1/689 , C12Q1/70 , C12Q2565/113 , C12Q2563/143 , C12Q2537/125 , C12Q2563/149
摘要： The invention provides methods to detect or determine the presence or amount of a pathogen, such as a virus or bacterium, in a sample or the amount of cells based on the detection of their genomic DNA. The method employs magnetic substrates and subjects the sample and the magnetic substrate to forms of energy so as to induce aggregate formation and detects the aggregates.
摘要翻译：本发明提供了检测或确定样品中病原体如病毒或细菌的存在或数量或基于其基因组DNA检测的细胞数量的方法。该方法采用磁性底物，并使样品和磁性底物形成能量，以便诱导聚集体形成并检测聚集体。

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