专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO0006199A8 KVLQT1 - A LONG QT SYNDROME GENE 审中-公开
标题翻译： KVLQT1 - 长QT综合征基因
公开(公告)号：WO0006199A8
公开(公告)日：2001-04-12
申请号：PCT/US9910260
申请日：1999-05-12
申请人： UNIV UTAH RES FOUND , GENZYME CORP
发明人： KEATING MARK T , SANGUINETTI MICHAEL C , CURRAN MARK E , LANDES GREGORY M , CONNORS TIMOTHY D , BURN TIMOTHY C , SPLAWSKI IGOR
IPC分类号： A01K67/027 , A61K48/00 , A61P9/06 , C07K14/46 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/577 , G01N33/58 , G01N33/68 , A61K39/395 , A01N37/18 , C07H21/02 , C12N5/00 , C12N15/00
CPC分类号： C07K14/47 , A01K2217/05 , A61K48/00 , C07K14/705 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The genomic structure including the sequence of the intron/exon junctions is disclosed for KVLQT1 and KCNE1 which are genes associated with long QT syndrome. Additional sequence data for the two genes are also disclosed. Also disclosed are newly found mutations in KVLQT1 which result in long QT syndrome. The intron/exon junction sequence data allow for the design of primer pairs to amplify and sequence across all of the exons of the two genes. This can be used to screen persons for the presence of mutations which cause long QT syndrome. Assays can be performed to screen persons for the presence of mutations in either the DNA or proteins. The DNA and proteins may also be used in assays to screen for drugs which will be useful in treating or preventing the occurrence of long QT syndrome.
摘要翻译：包括与长QT综合征相关的基因的KVLQT1和KCNE1的内含子/外显子连接序列的基因组结构公开。还公开了两种基因的附加序列数据。还公开了KVLQT1中新发现的突变，导致长QT综合征。内含子/外显子连接序列数据允许设计引物对以扩增和序列两个基因的所有外显子。这可以用于筛选造成长QT综合征的突变的存在。可以进行检测以筛选人们在DNA或蛋白质中存在突变。 DNA和蛋白质也可用于筛选可用于治疗或预防长QT综合征发生的药物的测定中。

2. 发明申请

WO9702346A3 NOVEL HUMAN CHROMOSOME 16 GENES, COMPOSITIONS, METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：新型人体色素16基因，组合物，制备方法和使用方法
公开(公告)号：WO9702346A3
公开(公告)日：1997-04-17
申请号：PCT/US9610469
申请日：1996-06-17
申请人： GENZYME CORP
发明人： LANDES GREGORY M , BURN TIMOTHY C , CONNORS TIMOTHY D , DACKOWSKI WILLIAM R , KLINGER KATHERINE W , VAN RAAY TERENCE J
IPC分类号： A01K67/027 , C07K14/47 , C07K14/475 , C07K16/18 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , C12N15/85
CPC分类号： C07K14/47 , A01K2217/05 , C07K14/475
摘要： In accordance with the present invention, there are provided isolated nucleic acids encoding a human netrin, a human ATPase binding cassette transporter, a human ribosomal L3 subtype, and a human augmenter of liver regeneration as well as isolated protein products encoded thereby. The present invention provides nucleic acid probes that hybridize to invention nucleic acids as well as isolated nucleic acids comprising unique gene sequences located on chromosome 16. Further provided are vectors containing invention nucleic acids, host cells transformed therewith, as well as transgenic non-human mammals that express invention polypeptides. The present invention includes antisense oligonucleotides, antibodies and compositions containing same. Additionally, the invention provides methods for identifying compounds that bind to invention polypeptides.

3. 发明申请

WO0157257A3 ISOLATION AND IDENTIFICATION OF MRNAS CORRELATING TO SECRETED PROTEINS 审中-公开
标题翻译：分离和鉴定与分泌蛋白相关的MRNA
公开(公告)号：WO0157257A3
公开(公告)日：2002-04-18
申请号：PCT/US0103464
申请日：2001-02-01
申请人： GENZYME CORP
发明人： LANDES GREGORY M
IPC分类号： A61K48/00 , C07H21/04 , C07K14/47 , C12N15/10 , C12Q1/68
CPC分类号： C12N15/1034 , C07K14/47
摘要： The present invention provides a method for isolating, identifying and cataloging partial messenger RNAs (mRNAs) or gene tags correlating to secreted and non-secreted proteins in a cell or tissue sample. The method requires obtaining a polynucleotide from a cellular homogenate, wherein the polynucleotide encodes the polypeptide and determining the sequence of the polynucleotide and its expression level. In essence, the method consists of two phases: (1) enrichment/purification of membrane-bound mRNA, and (2) sequence analysis. Neither of these processes, if performed independently of each other, would enable specific and rapid identification and enumeration of transcrips that encode secreted proteins and integral membrane bound proteins. This invention also provides computer-related systems and methods. More specifically, the invention provides a system and method for automatically generating a data base of gene tags corresponding to secreted and non-secreted proteins from cell or tissue samples and using the data base for filtering the tag counts from the samples into meaningful candidates for further testing and analysis.
摘要翻译：本发明提供了用于分离，鉴定和编目与细胞或组织样品中的分泌和非分泌蛋白相关的部分信使RNA（mRNA）或基因标签的方法。该方法需要从细胞匀浆中获得多核苷酸，其中多核苷酸编码多肽并确定多核苷酸的序列及其表达水平。实质上，该方法由两个阶段组成：（1）膜结合mRNA的富集/纯化，（2）序列分析。这些过程如果彼此独立地执行，将能够对编码分泌的蛋白质和整合的膜结合蛋白质的转录物进行特异且快速的鉴定和计数。本发明还提供计算机相关系统和方法。更具体地，本发明提供了一种系统和方法，用于自动生成对应于来自细胞或组织样品的分泌和非分泌蛋白质的基因标签的数据库，并且使用数据库将样品过滤到有意义的候选物中用于进一步测试和分析。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式