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    • 8. 发明申请
    • INFLATABLE BUBBLE
    • 充气泡
    • WO2011130349A3
    • 2012-04-05
    • PCT/US2011032223
    • 2011-04-13
    • ASIUS TECHNOLOGIES LLCAMBROSE STEPHEN DGIDO SAMUEL PSCHULEIN ROBERT B
    • AMBROSE STEPHEN DGIDO SAMUEL PSCHULEIN ROBERT B
    • H04R1/10G10K11/16
    • H04R1/1016H04R1/1091H04R25/65H04R25/656H04R25/658
    • An ear device having a bubble for placement approximate a user's ear canal and capable of inflation and deflation is disclosed. An inflation tube for delivering inflating air to the bubble during inflation of the bubble and an inflation source, such as a diaphonic valve, cause the bubble to extend automatically into the user's ear canal during inflation and retract from the user's ear canal during deflation. The bubble is substantially cylindrical and is comprised of a plurality of adjacently adjoined inflatable chambers. The bubble may also comprise at least one non- inflatable section interspersed therein. Where the ear device is used to convey sound to the user's ear, the device includes a sound tube positioned within the cylindrical bubble. At least one resilient member attached to a portion of the bubble, which may be a non-inflatable section of the bubble, is used to retract the bubble automatically. The ear device, equipped with a cerumen removing mechanism, may be used to clean a user's ear canal as well.
    • 公开了一种具有用于放置的气泡的耳朵装置,其接近用户的耳道并且能够进行充气和放气。 用于在气泡膨胀期间将膨胀空气输送到气泡的充气管,以及膨胀源(例如双声道阀),使得气泡在充气期间自动延伸到使用者的耳道中并在通气期间从使用者的耳道缩回。 气泡基本上是圆柱形的并且由多个相邻邻接的可充气室组成。 气泡还可以包括散布在其中的至少一个不可充气部分。 当耳机用于将声音传送到用户的耳朵时,该装置包括位于圆柱形气泡内的声管。 连接到气泡的一部分的至少一个弹性构件(其可以是气泡的不可充气部分)用于自动地缩回气泡。 装有耳垢去除机构的耳朵装置也可用于清洁使用者的耳道。
    • 10. 发明申请
    • ORIENTING POLYMER DOMAINS FOR CONTROLLED DRUG DELIVERY
    • 定向聚合物领域用于控制药物递送
    • WO2006062975A3
    • 2007-01-11
    • PCT/US2005044128
    • 2005-12-07
    • BOSTON SCIENT SCIMED INCRANADE SHRIRANG VRICHARD ROBERT EDAO KINH-LUAN LENNYGIDO SAMUEL PISAACS-SODEYE AKINBODE IDOWU
    • RANADE SHRIRANG VRICHARD ROBERT EDAO KINH-LUAN LENNYGIDO SAMUEL PISAACS-SODEYE AKINBODE IDOWU
    • A61L31/10A61L31/14A61L31/16
    • A61L31/10A61L31/14A61L31/16A61L2300/60A61L2300/602
    • The present invention provides a method for the formation of a medical device that comprises a therapeutic agent and a release region, which regulates the rate at which the therapeutic agent is released from the medical device. The method comprises providing a precursor region that comprises a polymer composition comprising two or more microphage separated polymer domains that are immiscible with one another, and forming said release region by a process that comprises applying an orienting field comprising an electric field, a magnetic field, a mechanical shear field, or a solvent gradient field, or a combination of two or more fields to said precursor region, wherein said field or combination of fields changes the spatial orientation of the microphase separated polymer domains within the release region. The electric, magnetic, mechanical shear or solvent gradient field is of sufficient strength to change the spatial orientation of the microphase separated domains. Moreover, the spatial orientation of the immiscible microphase separated polymer domains affects the rate of release of the therapeutic agent from the medical device. Hence, the present invention is further directed to methods of modulating the rate of release of a therapeutic agent from a medical device. Other aspects of the invention are directed to medical devices fromed from the above techniques.
    • 本发明提供一种形成医疗装置的方法,其包括治疗剂和释放区域,其调节治疗剂从医疗装置释放的速率。 该方法包括提供包含聚合物组合物的前体区域,该聚合物组合物包含彼此不混溶的两个或更多个微小间隔分离的聚合物区域,以及通过包括施加包括电场,磁场的取向场的方法形成所述释放区域, 机械剪切场或溶剂梯度场,或两个或更多个场的组合与所述前体区域,其中所述场或场的组合改变了微相分离的聚合物区域在释放区域内的空间取向。 电,磁,机械剪切或溶剂梯度场具有足够的强度来改变微相分离域的空间取向。 此外,不混溶的微相分离的聚合物区域的空间取向影响治疗剂从医疗装置释放的速率。 因此,本发明进一步涉及从医疗装置调节治疗剂释放速率的方法。 本发明的其它方面涉及来自上述技术的医疗装置。