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    • 1. 发明申请
    • HUMAN IPLA2T
    • 人类IPLA2T
    • WO2005059099A3
    • 2009-04-09
    • PCT/US2004041619
    • 2004-12-13
    • UNIV ST LOUISGROSS RICHARDJENKINS CHRISTOPHER M
    • GROSS RICHARDJENKINS CHRISTOPHER M
    • C12P21/06A01N29/04A01N61/00A61K38/00A61K49/00C07H21/04C07K1/00C12N20060101C12N9/20
    • C12N9/20A61K38/00
    • A novel function phospholipase A2, referred to herein as calcium­independent phospholipase A2? (iPLA2?) having SEQ ID NO: 1 and SEQ ID NO: 2, and nucleic acid sequences (SEQ ID NO: 3 and SEQ ID NO: 4) encoding and expressing iPLA2?. This novel enzyme has been isolated and characterized and is involved in the catalysis and hydrolysis of lipids cycling in a living cell biosystem. In an embodiment, the compromises to an isolated nucleic acid molecule comprising a set of iPLA2? polynucleotides. In an aspect of this embodiment, the iPLA2? polynucleotides encode and express an iPLA2? polypeptide. In one aspect, an isolated and characterized gene comprises a polynucleotide having a sequence shown in SEQ ID NO: 3 and SEQ ID NO: 4.
    • 一种新型功能磷脂酶A2,本文称为钙依赖性磷脂酶A2? 具有SEQ ID NO:1和SEQ ID NO:2的核酸序列(iPLA2β)和编码并表达iPLA2β的核酸序列(SEQ ID NO:3和SEQ ID NO:4)。 这种新型酶已经被分离和表征,并参与活细胞生物系统中脂质循环的催化和水解。 在一个实施方案中,对分离的核酸分子的折衷包括一组iPLA2? 多核苷酸。 在本实施例的一个方面,iPLA2? 多核苷酸编码并表达iPLA2? 多肽。 一方面,分离和表征的基因包含具有SEQ ID NO:3和SEQ ID NO:4所示序列的多核苷酸。