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    • 6. 发明申请
    • LOW THERMAL MASS FLUOROMETER
    • 低热质量FLUOROMETER
    • WO2006085911A2
    • 2006-08-17
    • PCT/US2005019584
    • 2005-06-03
    • UNIV SOUTH FLORIDAFARMER ANDREWFRIES DAVID PFLANERY BILL
    • FARMER ANDREWFRIES DAVID PFLANERY BILL
    • G01J1/58G01N21/03G01N21/64
    • G01N21/645G01N21/0332G01N2201/0221
    • The present invention provides core technologies necessary for a portable, low cost, thermal- regulating LED-based handheld fluorometer. The regulated fluorometer is based on al low thermal mass infrared heater, and an orthogonal geometry LED based filter fluorometer. Power is supplied through an external power supply and data is collected in real-time through standard serial interfaces of personal computers or personal digital assistants. Thermal regulation is automatically maintained using temperature sensor feedback control. Optical excitation relies on LED light source(s) and optical detection is through an adjustable integrating photodetector. Such a handheld system can allow applications requiring temperature sensitive photometric measurements for real time analyte detection to be performed in the field.
    • 本发明提供了便携式,低成本,热调节LED手持式荧光计所需的核心技术。 受控的荧光计基于低热质红外线加热器和基于正交几何结构的基于LED的过滤荧光计。 电源通过外部电源供电,数据通过个人电脑或个人数字助理的标准串行接口实时采集。 温度传感器反馈控制自动保持温度调节。 光学激励依赖于LED光源,而光学检测则通过可调整的积分光电探测器。 这种手持式系统可以允许在现场进行实时分析物检测的需要温度敏感的光度测量的应用。
    • 7. 发明申请
    • HANDHELD MICROARRAY READER
    • 手持式微型读卡器
    • WO2007047555A3
    • 2007-11-01
    • PCT/US2006040313
    • 2006-10-16
    • UNIV SOUTH FLORIDAFRIES DAVID PSMITH MATTHEW
    • FRIES DAVID PSMITH MATTHEW
    • G01N21/00
    • G01N21/6452G01N21/6428G01N21/76G01N2201/0221
    • A portable, handheld micro-chip array reader analyzes luminescence and/or chemical species in the environment. The handheld macro or micro-array chipbased reader device can detect and image small amounts of fluorescence or luminescence emitted from the array chips. The device utilizes night vision technology to effect trace detection of light emanating from array chips. The chips may consist of immobilized capture molecules (oligonucleotides or proteins) which facilitate the binding of a target analyte or individual, spatially separated wells that enable spatially separated amplification or hybridization to occur in any combination of immobilized or aqueous reaction. The night vision technology is able to detect interaction of the target analyte with the capture molecule via the use of a light emitting (fluorescent or luminescent) label or by photon emitting chemical reaction. Both qualitative and quantitative analyses are within the scope of the invention.
    • 便携式手持式微芯片阵列读取器分析环境中的发光和/或化学物质。 基于手持式或基于微阵列芯片的读取器装置可以检测和成像从阵列芯片发射的少量荧光或发光。 该设备利用夜视技术来实现从阵列芯片发出的光的踪迹检测。 芯片可以由固定化的捕获分子(寡核苷酸或蛋白质)组成,其有助于靶分析物或个体的结合,空间上分离的孔能够在空间分离的扩增或杂交中发生在固定化或含水反应的任何组合中。 夜视技术能够通过使用发光(荧光或发光)标签或通过光子发射化学反应来检测目标分析物与捕获分子的相互作用。 定性和定量分析都在本发明的范围内。
    • 9. 发明申请
    • METHOD AND APPARATUS FOR MASKLESS PHOTOLITHOGRAPHY
    • 方法和装置用于MASKLESS光刻技术
    • WO2004001508A3
    • 2004-08-05
    • PCT/US0320019
    • 2003-06-24
    • UNIV SOUTH FLORIDAFRIES DAVID P
    • FRIES DAVID P
    • G03F7/20G03F9/00
    • G03F7/70283G03F7/70291G03F9/7003
    • The present invention pertains to a method and apparatus to create two dimensional and three dimensional structures using a maskless photolithography system that is semi-automated, directly reconfigurable, and does not require masks, templates or stencils to create each of the planes or layers on multi layer two-dimensional or three dimensional structure. The subject invention also relates to a maskless photolithography system and method for creating gray scale patterns and large scale patterns on substrates. The system and method uses a maskless pattern generator to generate a patterned light beam for exposing photoreactive materials. In an embodiment, the pattern generator comprises a micromirror array wherein the positioning of the mirrors in the micromirror array and the time duration of exposure can be modulated to produce gray scale patterns to photoform layers of continuously variable thickness. In an alternate embodiment, the maskless pattern generator comprises a variably transmissive light filter, such as an LCD display, to variably filter light impinging on photoreactive materials to create gray scaled features. The desired pattern can be designed and stored using conventional computer aided drawing techniques and can be used to control the positioning of the individual mirrors in the micromirror array to reflect the corresponding desired pattern. In a specific embodiment, a fixture for mounting of the substrate can be incorporated and can allow the substrate to be moved three dimensions. In a embodiment, the fixture can be rotated in one, two, or three directions.
    • 本发明涉及使用半自动化,可直接重新配置的无掩模光刻系统来产生二维和三维结构的方法和装置,并且不需要掩模,模板或模板来在多层面上形成每个平面或层 层二维或三维结构。 本发明还涉及一种用于在衬底上产生灰度图案和大规模图案的无掩模光刻系统和方法。 该系统和方法使用无掩模图案发生器来产生用于曝光光反应性材料的图案化光束。 在一个实施例中,图案生成器包括微镜阵列,其中可以调制微镜阵列中的反射镜的定位和曝光的持续时间,以产生灰度图案,以形成连续可变厚度的成像层。 在替代实施例中,无掩模图案发生器包括可变透射的滤光器,例如LCD显示器,以可变地过滤入射光反射材料的光以产生灰度特征。 可以使用传统的计算机辅助绘图技术来设计和存储所需的图案,并且可以用于控制微镜阵列中的各个反射镜的定位以反映相应的期望图案。 在具体实施例中,可以并入用于安装基板的夹具,并且可以使基板移动三维。 在一个实施例中,固定装置可以沿一个,两个或三个方向旋转。