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1. 发明申请

WO2004108755A3 CHIMERIC ADENOVIRUS CAPSID PROTEINS 审中-公开
标题翻译： CHIMERIC ADENOVIRUS CAPSID蛋白
公开(公告)号：WO2004108755A3
公开(公告)日：2005-05-19
申请号：PCT/IB2004002532
申请日：2004-06-10
申请人： UNIV SASKATCHEWAN , TIKOO SURESH K , ZAKHARTCHOUK ALEXANDRE N , BABIUK LORNE A , KAUSHIK RADHEY S , GRIEBEL PHILIP J
发明人： TIKOO SURESH K , ZAKHARTCHOUK ALEXANDRE N , BABIUK LORNE A , KAUSHIK RADHEY S , GRIEBEL PHILIP J
IPC分类号： C07K14/075 , C12N15/861 , C12Q1/70
CPC分类号： C07K14/005 , C07K2319/33 , C12N2710/10322 , C12N2810/405 , C12N2810/859
摘要： The present invention relates to chimeric adenovirus capsid proteins comprising a part of or all of an adenovirus capsid protein and a binding partner of a cell-surface binding site on a cell present in gut associated lymphoid tissues (GALT) of a mammal, wherein the chimeric adenovirus capsid protein is capable of binding the cell present in gut associated lymphoid tissues (GALT). In some examples, the adenovirus capsid protein is located on the surface of the adenovirus capsid. The present invention provides adenovirus capsids comprising a chimeric capsid protein. The present invention also provides complexes comprising a chimeric adenovirus capsid protein bound to a cell in GALT. The present invention also provides encapsidation systems and vectors, in particular adenovirus vectors, capable of expressing a chimeric adenovirus capsid protein encompassed within the invention. The present invention also provides viral particles, host cells and compositions comprising such vectors, in particular for use in vaccines, methods of eliciting an immune response and methods for targeted delivery of heterologous proteins, such as antigens, to target cells.
摘要翻译：本发明涉及包含哺乳动物肠道相关淋巴组织（GALT）中存在的细胞上的一部分或全部腺病毒衣壳蛋白和细胞表面结合位点的结合配偶体的嵌合腺病毒衣壳蛋白，其中嵌合腺病毒衣壳蛋白能够结合存在于肠道相关淋巴组织（GALT）中的细胞。在一些实例中，腺病毒衣壳蛋白位于腺病毒衣壳的表面上。本发明提供了包含嵌合衣壳蛋白的腺病毒衣壳。本发明还提供了包含与GALT中的细胞结合的嵌合腺病毒衣壳蛋白的复合物。本发明还提供能够表达包含在本发明内的嵌合腺病毒衣壳蛋白的包衣系统和载体，特别是腺病毒载体。本发明还提供病毒颗粒，宿主细胞和包含这种载体的组合物，特别是用于疫苗，引发免疫应答的方法和用于将异源蛋白质例如抗原靶向递送至靶细胞的方法。

2. 发明申请

WO0026395A3 BOVINE CELLS EXPRESSING ADENOVIRUS ESSENTIAL FUNCTIONS FOR PROPAGATION OF RECOMBINANT ADENOVIRAL VECTORS 审中-公开
标题翻译：牛细胞表达重组腺病毒载体的腺病毒ESSENTIAL功能
公开(公告)号：WO0026395A3
公开(公告)日：2000-09-14
申请号：PCT/US9925677
申请日：1999-11-01
申请人： UNIV SASKATCHEWAN , TIKOO SURESH KUMAR , BABIUK LORNE A , REDDY POLICE SESHIDHAR
发明人： TIKOO SURESH KUMAR , BABIUK LORNE A , REDDY POLICE SESHIDHAR
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K48/00 , A61P3/10 , A61P7/04 , A61P9/00 , A61P19/00 , A61P31/12 , A61P35/00 , C12N5/02 , C12N5/10 , C12N7/01 , C12N15/861 , C12R1/91 , C12N15/86
CPC分类号： C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2710/10352 , Y10S424/813
摘要： The invention provides cell lines capable of supporting the replication of a defective recombinant virus vector. In one aspect, bovine cell lines expressing adenovirus E1 functions are provided. The cell lines are useful for the propagation of adenovirus vectors with mutations and/or deletions in E1 and other essential regions of the adenovirus genome.
摘要翻译：本发明提供了能够支持有缺陷的重组病毒载体复制的细胞系。一方面，提供了表达腺病毒E1功能的牛细胞系。细胞系可用于在E1和腺病毒基因组的其他必需区域中繁殖具有突变和/或缺失的腺病毒载体。

3. 发明申请

WO02077210A3 METHODS TO CULTURE CIRCOVIRUS 审中-公开
标题翻译：培养CIRCOVIRUS的方法
公开(公告)号：WO02077210A3
公开(公告)日：2003-08-21
申请号：PCT/CA0200413
申请日：2002-03-27
申请人： UNIV SASKATCHEWAN , LIU QIANG , TIKOO SURESH K , WILLSON PHILIP , BABIUK LORNE A
发明人： LIU QIANG , TIKOO SURESH K , WILLSON PHILIP , BABIUK LORNE A
IPC分类号： C12N15/09 , C07K14/075 , C12N5/02 , C12N5/10 , C12N7/00 , C12N7/01 , C12N15/34 , C12N15/86 , A61K39/12
CPC分类号： C07K14/005 , A61K2039/525 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2750/10021 , C12N2750/10043 , C12N2750/10052
摘要： The present invention relates to methods for culturing circovirus and in particular, porcine circovirus. The present invention provides compositions and methods for culturing porcine circovirus in mammalian cells expressing mammalian adenovirus E1 function.
摘要翻译：本发明涉及培养圆环病毒，特别是猪圆环病毒的方法。本发明提供了在表达哺乳动物腺病毒E1功能的哺乳动物细胞中培养猪圆环病毒的组合物和方法。

4. 发明申请

WO9929717A3 POSTWEANING MULTISYSTEMIC WASTING SYNDROME VIRUS FROM PIGS 审中-公开
标题翻译：从PIGS发布多用途的多发病毒综合症病毒
公开(公告)号：WO9929717A3
公开(公告)日：1999-10-07
申请号：PCT/CA9801130
申请日：1998-12-11
申请人： UNIV SASKATCHEWAN , WANG LI , BABIUK LORNE A , POTTER ANDREW A , WILLSON PHILIP
发明人： WANG LI , BABIUK LORNE A , POTTER ANDREW A , WILLSON PHILIP
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/12 , A61P31/20 , C07K14/01 , C07K16/08 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/34 , C12N15/63 , C12P21/02 , C12Q1/68 , C12Q1/70 , C12R1/92 , G01N33/569
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/12 , A61K2039/552 , C12N7/00 , C12N15/86 , C12N2750/10022 , C12N2750/10043 , C12Q1/701
摘要： The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and treatment of PCVII infections, as well as in diagnostic methods for determining the presence of PCVII infections in a vertebrate subject. Polynucleotides derived from the viral genome can be used as diagnostic primers and probes.
摘要翻译：新型PCVII病毒基因组的克隆描述为源自PCVII基因组的蛋白质的表达。这些蛋白质可用于预防和治疗PCVII感染的疫苗组合物中，以及用于确定脊椎动物受试者中PCVII感染存在的诊断方法。衍生自病毒基因组的多核苷酸可用作诊断引物和探针。

5. 发明申请

WO9859063A3 BOVINE ADENOVIRUS TYPE 3 GENOME 审中-公开
标题翻译：牛血清型腺病毒3型基因
公开(公告)号：WO9859063A3
公开(公告)日：1999-07-29
申请号：PCT/CA9800624
申请日：1998-06-23
申请人： UNIV SASKATCHEWAN , BABIUK LORNE A , TIKOO SURESH KUMAR , REDDY POLICE SESHIDAR
发明人： BABIUK LORNE A , TIKOO SURESH KUMAR , REDDY POLICE SESHIDAR
IPC分类号： C12N15/09 , A61K31/711 , A61K35/76 , A61K38/00 , A61K38/22 , A61K38/43 , A61K38/44 , A61K38/46 , A61K39/00 , A61K48/00 , A61P31/00 , A61P37/04 , C07K14/075 , C07K16/08 , C12N1/21 , C12N5/10 , C12N7/01 , C12N7/02 , C12N15/861 , C12P21/02 , C12Q1/68 , C12R1/19 , C12R1/91 , C12R1/93 , C12N15/86 , A61K39/235 , G01N33/50
CPC分类号： C12N15/86 , A61K39/00 , A61K2039/51 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343
摘要： In one embodiment, the present invention relates to novel bovine adenovirus expression vector systems which utilize the following regions of the bovine adenovirus genome: nucleotides 4,092-5,234; nucleotides 5,892-17,735; nucleotides 21,198-26,033 and nucleotides 31,133-34,445. These regions can be used, among other things, for insertion of foreign sequences, for provision of DNA control sequences including transcriptional and translational regulatory sequences, or for diagnostic purposes to detect the presence of viral nucleic acids or proteins encoded by these regions, in a subject or biological sample. In another embodiment, the present invention relates to novel methods for the construction, isolation and propagation of recombinant bovine adenovirus (BAV) with deletions (and optionally insertions of heterologous sequence) in the E3 region. Recombinant BAV containing insertions of genes encoding protective determinants of a pathogen stimulate enhanced systemic and mucosal immune responses and protect host animals against challenge by the pathogen.
摘要翻译：在一个实施方案中，本发明涉及利用牛腺病毒基因组的以下区域的新型牛腺病毒表达载体系统：核苷酸4,092-5,234; 核苷酸5,892-17,735; 核苷酸21,198-26,033和核苷酸31,133-34,445。这些区域可以用于插入外来序列，用于提供包括转录和翻译调节序列的DNA控制序列，或用于诊断目的以检测由这些区域编码的病毒核酸或蛋白质的存在，主题或生物样本。在另一个实施方案中，本发明涉及在E3区域中构建，分离和繁殖重组牛腺病毒（BAV）的新颖方法，其具有缺失（并且任选插入异源序列）。含有编码病原体保护性决定簇基因插入片段的重组BAV刺激增强的全身和粘膜免疫应答，保护宿主动物免受病原体的攻击。

6. 发明申请

WO9953047A2 PORCINE ADENOVIRUS TYPE 3 GENOME 审中-公开
公开(公告)号：WO9953047A2
公开(公告)日：1999-10-21
申请号：PCT/US9908220
申请日：1999-04-15
申请人： UNIV SASKATCHEWAN , REDDY POLICE SESHIDHAR , TIKOO SURESH KUMAR , BABIUK LORNE A
发明人： REDDY POLICE SESHIDHAR , TIKOO SURESH KUMAR , BABIUK LORNE A
IPC分类号： G01N33/50 , A61K39/235 , A61K48/00 , A61P31/12 , A61P37/04 , C07K14/075 , C07K16/08 , C12N5/10 , C12N7/04 , C12N15/09 , C12N15/861 , C12Q1/68 , G01N33/53 , G01N33/566 , C12N15/00
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10362
摘要： The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3) is provided. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells are provided. Recombinant PAV viruses are obtained by transfection of mammalian cells with recombinant PAV genomes. The PAV-3 genome can be used as a vector for the expression of heterologous nucleotide sequences, for example, for the preparation and administration of subunit vaccines to swine or other mammals. In addition, PAV-3 vectors can be used for gene therapy and expression of heterologous polypeptides. PAV-3 genome sequences can also be used for diagnostic purposes, to detect the presence of PAV-3 DNA in a subject or biological sample.
摘要翻译：提供猪腺病毒3型（PAV-3）基因组的完整核苷酸序列。提供了在原核细胞中通过同源重组构建感染性PAV基因组的方法。通过用重组PAV基因组转染哺乳动物细胞获得重组PAV病毒。 PAV-3基因组可用作异源核苷酸序列表达的载体，例如用于制备和施用猪或其他哺乳动物的亚单位疫苗。此外，PAV-3载体可用于基因治疗和异源多肽的表达。 PAV-3基因组序列也可用于诊断目的，以检测受试者或生物样品中PAV-3 DNA的存在。

7. 发明申请

WO9516048A3 RECOMBINANT PROTEIN PRODUCTION IN BOVINE ADENOVIRUS EXPRESSION VECTOR SYSTEM 审中-公开
标题翻译：牛血清型表达载体系统中重组蛋白的生产
公开(公告)号：WO9516048A3
公开(公告)日：1995-09-28
申请号：PCT/CA9400678
申请日：1994-12-09
申请人： UNIV SASKATCHEWAN
发明人： MITTAL SURESH K , GRAHAM FRANK L , PREVEC LUDVIK , BABIUK LORNE A
IPC分类号： A61K48/00 , C07K14/075 , C12N7/01 , C12N15/861 , C12N15/86 , C12N5/10 , C12R1/92
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C12N2710/10322 , C12N2710/10343 , C12N2710/10352
摘要： The present invention relates to novel live bovine adenovirus (BAV) expression vector systems in which part or all of one or both of the early region 1 (E1) and early region 3 (E3) genes are deleted and replaced by a foreign gene or fragment thereof and novel recombinant mammalian cell lines stably transformed with BAV E1 sequences, and therefore, express E1 gene products capable of allowing replication therein of a bovine adenovirus having an E1 deletion replaced by a heterologous nucleotide sequence encoding a foreign gene or fragment thereof and their use in production of (antigenic) polypeptides or fragments thereof for the purpose of live recombinant virus or subunit vaccine or for other therapies.

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