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    • 1. 发明申请
    • METHODS TO PREPARE PATCHY MICROPARTICLES
    • 制备贴剂微粒的方法
    • WO2011044328A3
    • 2011-09-29
    • PCT/US2010051771
    • 2010-10-07
    • UNIV PITTSBURGHLITTLE STEVEN RKAMALASANAN KALADHAR
    • LITTLE STEVEN RKAMALASANAN KALADHAR
    • B01J13/02B01J13/14
    • B01J13/18Y10T428/2982Y10T428/2991
    • A method for making microparticles having an exterior surface that includes preparing a self-assembled arrangement of microparticles; contacting the self- assembled microparticles with a patch-forming agent resulting in a microparticle/patch-forming agent assembly having proximal regions between adjacent microparticles and/or proximal regions between a microparticle and another substrate, wherein the patch-forming agent is present in the proximal region; and condensing the patch- forming agent such that a pattern of a plurality of discrete patches of patch-forming agent are formed on the exterior surfaces of the microparticles at the proximal regions. A synthetic microsphere having an exterior spherical surface, wherein the exterior spherical surface comprises a first material and a plurality of discrete, uniformly-dimensioned, patches of a second bioactive material arranged in an orderly array over more than one hemisphere of the microsphere.
    • 一种制造具有外表面的微粒的方法,所述方法包括制备微粒的自组装排列; 使自组装微粒与补丁形成剂接触,产生微粒/补丁形成剂组件,其具有邻近微粒之间的近侧区域和/或微粒与另一基底之间的近侧区域,其中所述补丁形成剂存在于 近端区域; 以及使所述斑块形成剂冷凝,使得在所述近端区域处的所述微粒的外表面上形成斑块形成剂的多个离散贴片的图案。 具有外部球形表面的合成微球体,其中所述外部球形表面包含第一材料和多个离散的,均匀尺寸的第二生物活性材料的贴片,所述第二生物活性材料贴片以有序排列的方式排列在所述微球体的多于一个半球上。