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1. 发明申请

WO2006050365A3 METHODS FOR PRODUCTION OF SYNTHETIC HYDROXYAPATITE NANORODS 审中-公开
标题翻译：合成羟基磷酸酯的制备方法
公开(公告)号：WO2006050365A3
公开(公告)日：2006-11-02
申请号：PCT/US2005039492
申请日：2005-10-28
申请人： UNIV MICHIGAN , CLARKSON BRIAN H , CHEN HAIFENG
发明人： CLARKSON BRIAN H , CHEN HAIFENG
IPC分类号： A61L27/32 , C01B25/32
CPC分类号： C01B25/455 , C01B25/32
摘要： Disclosed herein are methods directed toward the synthesis of ordered structures of hydroxyapatite and hydroxyapatite derivatives. More specifically, disclosed herein is a method of preparing ordered hydroxyapatite nanorod structures including the steps of suspending calcium and phosphate in a solvent, adjusting the pH to above 5, and heating to a temperature sufficient to support formation of the ordered hydroxyapatite nanorod structures. In some cases, the methods may include ethylenediamine tetraacetic acid or ethylenediamine tetraacetic acid derivatives. Also disclosed are methods that additionally involve a step of coating hydroxyapatite nanorods with a protein or an amphiphile such as a surfactant or polymer.
摘要翻译：本文公开了涉及合成羟基磷灰石和羟基磷灰石衍生物的有序结构的方法。更具体地，本文公开了制备有序羟基磷灰石纳米棒结构的方法，包括以下步骤：将钙和磷酸盐悬浮在溶剂中，将pH调节至5以上，并加热至足以支持形成有序羟磷灰石纳米棒结构的温度。在一些情况下，所述方法可以包括乙二胺四乙酸或乙二胺四乙酸衍生物。还公开了另外涉及用蛋白质或两亲物如表面活性剂或聚合物涂覆羟基磷灰石纳米棒的步骤的方法。

2. 发明申请

WO2011057180A2 COMPOSITIONS OF APATITE AND METHODS OF USE 审中-公开
标题翻译： APATITE的组成和使用方法
公开(公告)号：WO2011057180A2
公开(公告)日：2011-05-12
申请号：PCT/US2010055805
申请日：2010-11-08
申请人： UNIV MICHIGAN , CLARKSON BRIAN H , KURODA KENICHI
发明人： CLARKSON BRIAN H , KURODA KENICHI
IPC分类号： A61K33/16 , A61K6/02 , A61K6/027 , A61K47/02 , A61K47/30
CPC分类号： A61K33/42 , A61K6/0017 , A61K6/0038 , A61K6/033 , A61K6/083 , A61K8/19 , A61K8/24 , A61K8/8152 , A61K9/0063 , A61Q11/00 , C08L33/00
摘要： Compositions of apatite derivative crystals are disclosed herein. Also disclosed are methods of using these compositions to treat tooth sensitivity, to use as an anticaries treatment, to use as a restorative material, to use as a tooth surface whitener, and to combat or lessen the side effects of tooth whitening.
摘要翻译：磷灰石衍生物晶体的组成在本文中公开。还公开了使用这些组合物治疗牙齿敏感性，用作防龋治疗，用作修复材料，用作牙齿增白剂，以及对抗或减轻牙齿增白的副作用的方法。

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