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1. 发明申请

WO2007078599A9 FUNCTIONAL ARRAYS FOR HIGH THROUGHPUT CHARACTERIZATION OF GENE EXPRESSION REGULATORY ELEMENTS 审中-公开
标题翻译：功能阵列用于基因表达调控元件的高通量表征
公开(公告)号：WO2007078599A9
公开(公告)日：2007-10-04
申请号：PCT/US2006046920
申请日：2006-12-08
申请人： UNIV LELAND STANFORD JUNIOR , TRINKLEIN NATHAN D , ALDRED SHELLEY F , COOPER SARA J , MYERS RICHARD M
发明人： TRINKLEIN NATHAN D , ALDRED SHELLEY F , COOPER SARA J , MYERS RICHARD M
IPC分类号： C40B30/06 , C40B40/02 , C40B50/06
CPC分类号： C12N15/1086 , C12Q1/6897
摘要： The present invention provides compositions, kits, assemblies, libraries, arrays, and high throughput methods for large scale structural and functional characterization of gene expression regulatory elements in a genome of an organism, especially in a human genome. In one aspect of the invention, an array of expression constructs is provided, e.ach of the expression constructs comprising: a nucleic acid segment operably linked with a reporter sequence in an expression vector such that expression of the reporter sequence is under the transcriptional control of the nucleic acid segment, the nucleic acid segment varying in the library and having a diversity of at least 50. The nucleic acid segments can be a large library of gene expression regulatory elements such as transcriptional promoters. The present invention can have a wide variety of applications such as in personalized medicine, pharmacogenomics, and correlation of polymorphisms with phenotypic traits.
摘要翻译：本发明提供用于大规模结构和功能表征生物基因组中基因表达调控元件，特别是人类基因组中的基因表达调控元件的组合物，试剂盒，组件，文库，阵列和高通量方法。在本发明的一个方面，提供了一系列表达构建体，其中一些表达构建体包含：与表达载体中的报道子序列可操作地连接的核酸区段，使得报道子序列的表达处于转录控制的核酸片段，所述核酸片段在所述文库中变化并且具有至少50的多样性。所述核酸片段可以是基因表达调控元件的大文库，例如转录启动子。本发明可以具有广泛的应用，例如在个性化医学，药物基因组学和多态性与表型性状的相关性中。

2. 发明申请

WO2007078599A2 FUNCTIONAL ARRAYS FOR HIGH THROUGHPUT CHARACTERIZATION OF GENE EXPRESSION REGULATORY ELEMENTS 审中-公开
标题翻译：用于基因表达调控元件的高通量表征的功能阵列
公开(公告)号：WO2007078599A2
公开(公告)日：2007-07-12
申请号：PCT/US2006046920
申请日：2006-12-08
申请人： UNIV LELAND STANFORD JUNIOR , TRINKLEIN NATHAN D , ALDRED SHELLEY F , COOPER SARA J , MYERS RICHARD M
发明人： TRINKLEIN NATHAN D , ALDRED SHELLEY F , COOPER SARA J , MYERS RICHARD M
IPC分类号： C40B30/06 , C40B40/02 , C40B50/06
CPC分类号： C12N15/1086 , C12Q1/6897
摘要： The present invention provides compositions, kits, assemblies, libraries, arrays, and high throughput methods for large scale structural and functional characterization of gene expression regulatory elements in a genome of an organism, especially in a human genome. In one aspect of the invention, an array of expression constructs is provided, e.ach of the expression constructs comprising: a nucleic acid segment operably linked with a reporter sequence in an expression vector such that expression of the reporter sequence is under the transcriptional control of the nucleic acid segment, the nucleic acid segment varying in the library and having a diversity of at least 50. The nucleic acid segments can be a large library of gene expression regulatory elements such as transcriptional promoters. The present invention can have a wide variety of applications such as in personalized medicine, pharmacogenomics, and correlation of polymorphisms with phenotypic traits.
摘要翻译：本发明提供组合物，试剂盒，组装，文库，阵列和高通量方法，用于在生物体，特别是人类基因组的基因组中的基因表达调控元件的大规模结构和功能表征。在本发明的一个方面，提供了一系列表达构建体，每个表达构建体包括：与表达载体中的报告基因序列可操作地连接的核酸区段，使得报告序列的表达在转录控制下的核酸片段，核酸片段在文库中变化并且具有至多50的多样性。核酸片段可以是基因表达调节元件如转录启动子的大型文库。本发明可以具有广泛的应用，例如个性化医学，药物基因组学和多态性与表型性状的相关性。

3. 发明申请

WO2007078599A8 FUNCTIONAL ARRAYS FOR HIGH THROUGHPUT CHARACTERIZATION OF GENE EXPRESSION REGULATORY ELEMENTS 审中-公开
公开(公告)号：WO2007078599A8
公开(公告)日：2008-10-30
申请号：PCT/US2006046920
申请日：2006-12-08
申请人： UNIV LELAND STANFORD JUNIOR , TRINKLEIN NATHAN D , ALDRED SHELLEY F , COOPER SARA J , MYERS RICHARD M
发明人： TRINKLEIN NATHAN D , ALDRED SHELLEY F , COOPER SARA J , MYERS RICHARD M
IPC分类号： C12Q1/68 , C12N5/00
CPC分类号： C12N15/1086 , C12Q1/6897
摘要： The present invention provides compositions, kits, assemblies, libraries, arrays, and high throughput methods for large scale structural and functional characterization of gene expression regulatory elements in a genome of an organism, especially in a human genome. In one aspect of the invention, an array of expression constructs is provided, e.ach of the expression constructs comprising: a nucleic acid segment operably linked with a reporter sequence in an expression vector such that expression of the reporter sequence is under the transcriptional control of the nucleic acid segment, the nucleic acid segment varying in the library and having a diversity of at least 50. The nucleic acid segments can be a large library of gene expression regulatory elements such as transcriptional promoters. The present invention can have a wide variety of applications such as in personalized medicine, pharmacogenomics, and correlation of polymorphisms with phenotypic traits.

4. 发明申请

WO2007059064A3 FGF2-RELATED METHODS FOR DIAGNOSING AND TREATING DEPRESSION 审中-公开
标题翻译： FGF2相关方法诊断和治疗抑郁症
公开(公告)号：WO2007059064A3
公开(公告)日：2009-05-22
申请号：PCT/US2006044057
申请日：2006-11-13
申请人： UNIV LELAND STANFORD JUNIOR , AKIL HUDA , WATSON STANLEY J , EVANS SIMON J , TURNER CORTNEY , BERNARD RENE , KERMAN ILAN , THOMPSON ROBERT C , BURMEISTER MARGIT , SCOTT LAURA J , MENG FAN , BOEHNKE MICHAEL , BUNNEY WILLIAM E JR , VAWTER MARQUIS P , JONES EDWARD G , CHOUDARY PRABHAKARA V , MYERS RICHARD M , SCHATZBERG ALAN F , LI JUN , ABSHER DEVIN , TOMITA HIROAKI
发明人： AKIL HUDA , WATSON STANLEY J , EVANS SIMON J , TURNER CORTNEY , BERNARD RENE , KERMAN ILAN , THOMPSON ROBERT C , BURMEISTER MARGIT , SCOTT LAURA J , MENG FAN , BOEHNKE MICHAEL , BUNNEY WILLIAM E JR , VAWTER MARQUIS P , JONES EDWARD G , CHOUDARY PRABHAKARA V , MYERS RICHARD M , SCHATZBERG ALAN F , LI JUN , ABSHER DEVIN , TOMITA HIROAKI
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04 , C12M1/34
CPC分类号： C12Q1/6883 , A61K38/03 , A61K38/10 , A61K38/1774 , A61K38/1825 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N2800/304
摘要： The present application relates to the treatment and diagnosis of mood disorders, including bipolar disorder, major depression disorder and schizophrenia. The invention provides novel diagnostic markers and assays, as well as research tools for the development and discovery of agents and compounds which are useful for treating patients who suffer from mental illness.
摘要翻译：本申请涉及心理障碍的治疗和诊断，包括双相情感障碍，重症抑郁障碍和精神分裂症。本发明提供了新的诊断标记和测定，以及用于开发和发现可用于治疗患有精神疾病的患者的药剂和化合物的研究工具。

5. 发明申请

WO2008057691A3 SNP DETECTION AND OTHER METHODS FOR CHARACTERIZING AND TREATING BIPOLAR DISORDER AND OTHER AILMENTS 审中-公开
标题翻译：表征和处理双极性疾病及其他物质的SNP检测及其他方法
公开(公告)号：WO2008057691A3
公开(公告)日：2009-03-12
申请号：PCT/US2007080732
申请日：2007-10-08
申请人： UNIV LELAND STANFORD JUNIOR , AKIL HUDA , WATSON STANLEY J , EVANS SIMON J , TURNER CORTNEY , BERNARD RENE , KERMAN ILAN , THOMPSON ROBERT C , BURMEISTER MARGIT , SCOTT LAURA J , MENG FAN , BOEHNKE MICHAEL , BUNNEY WILLIAM E , VAWTER MARQUIS P , JONES EDWARD G , CHOUDARY PRABHAKARA V , MYERS RICHARD M , SCHATZBERG ALAN F , LI JUN , ABSHER DEVIN
发明人： AKIL HUDA , WATSON STANLEY J , EVANS SIMON J , TURNER CORTNEY , BERNARD RENE , KERMAN ILAN , THOMPSON ROBERT C , BURMEISTER MARGIT , SCOTT LAURA J , MENG FAN , BOEHNKE MICHAEL , BUNNEY WILLIAM E , VAWTER MARQUIS P , JONES EDWARD G , CHOUDARY PRABHAKARA V , MYERS RICHARD M , SCHATZBERG ALAN F , LI JUN , ABSHER DEVIN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present application relates to the use of SNPs and differential exon expression to characterize, diagnose or treat bipolar disorder and other mental illnesses, such as major depressive disorder and schizophrenia.
摘要翻译：本申请涉及使用SNP和差异外显子表达来表征，诊断或治疗双相情感障碍和其他精神疾病，如重度抑郁障碍和精神分裂症。

6. 发明申请

WO2012138609A3 METHYLATION BIOMARKERS FOR DIAGNOSIS OF PROSTATE CANCER 审中-公开
标题翻译：用于诊断前列腺癌的甲基生物标志物
公开(公告)号：WO2012138609A3
公开(公告)日：2012-12-13
申请号：PCT/US2012031876
申请日：2012-04-02
申请人： UNIV LELAND STANFORD JUNIOR , HUDSONALPHA INST FOR BIOTECHNOLOGY , SHERLOCK GAVIN J , BROOKS JAMES DUANE , MYERS RICHARD M , KOBAYASHI YUYA , ABSHER DEVIN M
发明人： SHERLOCK GAVIN J , BROOKS JAMES DUANE , MYERS RICHARD M , KOBAYASHI YUYA , ABSHER DEVIN M
IPC分类号： G01N33/48
CPC分类号： C12Q1/6886 , C12Q2600/154
摘要： Biomarkers for diagnosis and prognosis of prostate cancer are provided. The biomarkers are promoter sequences have altered methylation patterns relative to normal prostate tissue. Altered expression of DNA methyltransferases (DNMT) and proteins that interact with DNMT result in increased methylation at a subset of prostate tumor hypermethylation sites.
摘要翻译：提供了用于诊断和预后的前列腺癌的生物标志物。生物标志物是相对于正常前列腺组织具有改变的甲基化模式的启动子序列。改变DNA甲基转移酶（DNMT）和与DNMT相互作用的蛋白质的表达导致前列腺肿瘤高甲基化位点子集上的甲基化增加。

7. 发明申请

WO2008057691A9 SNP DETECTION AND OTHER METHODS FOR CHARACTERIZING AND TREATING BIPOLAR DISORDER AND OTHER AILMENTS 审中-公开
标题翻译：单核苷酸多态性检测和其他方法来表征和治疗双相情感障碍和其他病症
公开(公告)号：WO2008057691A9
公开(公告)日：2008-10-02
申请号：PCT/US2007080732
申请日：2007-10-08
申请人： UNIV LELAND STANFORD JUNIOR , AKIL HUDA , WATSON STANLEY J , EVANS SIMON J , TURNER CORTNEY , BERNARD RENE , KERMAN ILAN , THOMPSON ROBERT C , BURMEISTER MARGIT , SCOTT LAURA J , MENG FAN , BOEHNKE MICHAEL , BUNNEY WILLIAM E , VAWTER MARQUIS P , JONES EDWARD G , CHOUDARY PRABHAKARA V , MYERS RICHARD M , SCHATZBERG ALAN F , LI JUN , ABSHER DEVIN
发明人： AKIL HUDA , WATSON STANLEY J , EVANS SIMON J , TURNER CORTNEY , BERNARD RENE , KERMAN ILAN , THOMPSON ROBERT C , BURMEISTER MARGIT , SCOTT LAURA J , MENG FAN , BOEHNKE MICHAEL , BUNNEY WILLIAM E , VAWTER MARQUIS P , JONES EDWARD G , CHOUDARY PRABHAKARA V , MYERS RICHARD M , SCHATZBERG ALAN F , LI JUN , ABSHER DEVIN
IPC分类号： G01N33/50 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present application relates to the use of SNPs and differential exon expression to characterize, diagnose or treat bipolar disorder and other mental illnesses, such as major depressive disorder and schizophrenia.
摘要翻译：本申请涉及使用SNP和差别外显子表达来表征，诊断或治疗躁郁症和其他精神疾病，例如重度抑郁症和精神分裂症。

8. 发明申请

WO2006002262A3 GENES AND PATHWAYS DIFFERENTIALLY EXPRESSED IN BIPOLAR DISORDER AND/OR MAJOR DEPRESSIVE DISORDER 审中-公开
标题翻译：基因和途径在双胞胎疾病和/或主要的严重疾病中明显不同
公开(公告)号：WO2006002262A3
公开(公告)日：2007-06-14
申请号：PCT/US2005022111
申请日：2005-06-21
申请人： UNIV LELAND STANFORD JUNIOR , AKIL HUDA , BUNNEY JR WILLIAM E , CHOUDARY PRABHAKARA V , EVANS SIMON J , JONES EDWARD G , LI JUN , LOPEZ JUAN F , LYONS DAVID M , MOLNAR MARGHERITA , MYERS RICHARD M , SCHATZBERG ALAN F , STEIN RICHARD , THOMPSON ROBERT C , TOMITA HIROAKI , VAWTER MARQUIS P , WATSON STANLEY J
发明人： AKIL HUDA , BUNNEY JR WILLIAM E , CHOUDARY PRABHAKARA V , EVANS SIMON J , JONES EDWARD G , LI JUN , LOPEZ JUAN F , LYONS DAVID M , MOLNAR MARGHERITA , MYERS RICHARD M , SCHATZBERG ALAN F , STEIN RICHARD , THOMPSON ROBERT C , TOMITA HIROAKI , VAWTER MARQUIS P , WATSON STANLEY J
IPC分类号： C12Q1/68 , A61K38/00 , A61K48/00 , G01N33/53
CPC分类号： C12Q1/6883 , A61K31/713 , A61K38/1825 , C07K16/22 , C12N15/1136 , C12N2310/14 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6896 , G01N33/74 , G01N2333/726 , G01N2800/304
摘要： The present invention provides methods for diagnosing mental disorders. The invention also provides methods of identifying modulators of mental disorders as well as methods of using these modulators to treat patients suffering from mental disorders.
摘要翻译：本发明提供诊断精神障碍的方法。本发明还提供鉴定精神障碍调节剂的方法以及使用这些调节剂治疗患有精神障碍的患者的方法。

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