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1. 发明申请

WO2006099176A3 3-D INTERCONNECTED MULTI-LAYER MICROSTRUCTURE OF THERMOPLASTIC MATERIALS 审中-公开
标题翻译：热塑性材料3-D互连多层微结构
公开(公告)号：WO2006099176A3
公开(公告)日：2009-05-07
申请号：PCT/US2006008660
申请日：2006-03-08
申请人： UNIV LELAND STANFORD JUNIOR , RYU WONHYOUNG , JAI BAI SEOUNG , HAMMERICK KYLE , SMITH ROBERT LANE , GRECO RALPH S , PRINZ FRIEDRICH B , FASCHING RAINER J
发明人： RYU WONHYOUNG , JAI BAI SEOUNG , HAMMERICK KYLE , SMITH ROBERT LANE , GRECO RALPH S , PRINZ FRIEDRICH B , FASCHING RAINER J
IPC分类号： B44C1/22 , B01L3/00 , B28B1/00 , B29B7/00 , B29C33/00 , B29C33/40 , B29C43/02 , B29C45/00 , B29C59/02 , B29C59/04
CPC分类号： B29C43/021 , B01L3/5027 , B01L3/5085 , B29C33/0033 , B29C33/424 , B29C43/003 , B29C59/02 , B29C59/022 , B29C59/04 , B29C2043/025 , B29C2043/463 , B29C2043/5883 , B29C2059/023 , B29L2031/7532
摘要： Methods for compression molding through holes in polymer layers are provided, as are the resulting patterned polymer layers. Two key aspects of the invention are provision of a mold and substrate having different mechanical hardness , and provision of room for local flow of material. These aspects of the invention facilitate formation of through holes by compression molding that are not blocked or partially blocked by undesirable material. These polymer layers can be formed into three dimensional patterned structures by bonding patterned layers together. Since the layers include through holes, a three-dimensional polymer pattern can be formed. These patterned polymer layers and three dimensionally patterned polymer constructs have a wide variety of applications. For example, these constructs can be used for fabrication of micro-f luidic devices, and/or can be used for various medical and biological applications including drug delivery devices and tissue engineering devices.
摘要翻译：提供了聚合物层中的孔的压缩模塑方法，以及所形成的图案化聚合物层。本发明的两个关键方面是提供具有不同机械硬度的模具和基材，并提供用于局部流动材料的空间。本发明的这些方面有助于通过压缩成型形成未被不期望的材料阻挡或部分阻挡的通孔。这些聚合物层可以通过将图案化层结合在一起而形成三维图案化结构。由于层包括通孔，因此可以形成三维聚合物图案。这些图案化的聚合物层和三维图案化的聚合物构造物具有广泛的应用。例如，这些构建体可用于制造微流体装置，和/或可用于各种医疗和生物应用，包括药物递送装置和组织工程装置。

2. 发明申请

WO2006034470A3 SENSORS FOR ELECTROCHEMICAL, ELECTRICAL OR TOPOGRAPHICAL ANALYSIS 审中-公开
标题翻译：电化学，电气或地理分析传感器
公开(公告)号：WO2006034470A3
公开(公告)日：2007-11-15
申请号：PCT/US2005034234
申请日：2005-09-23
申请人： UNIV LELAND STANFORD JUNIOR , PRINZ FRIEDRICH B , TAO YE , FASCHING RAINER J , GRECO RALPH S , HAMMERICK KYLE , SMITH ROBERT LANE
发明人： PRINZ FRIEDRICH B , TAO YE , FASCHING RAINER J , GRECO RALPH S , HAMMERICK KYLE , SMITH ROBERT LANE
IPC分类号： B82B1/00 , B82B3/00 , G01Q10/00 , G01Q60/02 , G01Q60/38 , G01Q60/60 , H01L21/3065
CPC分类号： G01Q60/02 , G01Q60/38 , G01Q60/60 , Y10S977/86 , Y10S977/869 , Y10S977/875
摘要： Sensors (100, 520) and systems for electrical, electrochemical, or topographical analysis, as well as methods of fabricating these sensors are provided The sensors include a cantilever (110, 524) and one or more probes (120, 522), each of which has an electrode (126) at its tip (122) The tips of the probes are sharp, with a radius of curvature of less than about 50 nm In addition, the probes have a high aspect ratio of more than about 19 :1. The sensors are suitable for both Atomic Force Microscopy and Scanning Electrochemical Microscopy.
摘要翻译：提供了传感器（100,520）以及用于电气，电化学或地形分析的系统以及制造这些传感器的方法。传感器包括悬臂（110,524）和一个或多个探针（120,522），每个探针其尖端（122）具有电极（126）。探针的尖端是锐利的，其曲率半径小于约50nm。此外，探针的高纵横比大于约19:1。传感器适用于原子力显微镜和扫描电化学显微镜。

3. 发明申请

WO02092778A3 DEVICE AND METHOD FOR THREE-DIMENSIONAL SPATIAL LOCALIZATION AND FUNCTIONAL INTERCONNECTION OF DIFFERENT TYPES OF CELLS 审中-公开
标题翻译：三维空间定位和功能互连不同类型细胞的装置和方法
公开(公告)号：WO02092778A3
公开(公告)日：2003-05-30
申请号：PCT/US0215746
申请日：2002-05-17
申请人： UNIV LELAND STANFORD JUNIOR
发明人： HAMMERICK KYLE , PRINZ FRIEDRICH B , SMITH ROBERT LANE , GRECO RALPH S , FASCHNG RAINER
IPC分类号： C12M3/00 , C12N20060101 , C12N5/00 , C12N5/08
CPC分类号： C12M3/00 , C12N5/0062 , C12N2503/00
摘要： A device (10), method and process for three-dimensional spatial localization and functional interconnection of the same or different types of cells. The two or three-dimensional device (10) comprising multiple layers (12, 14, 16, 18) containing wells (26) for cell deposition where both the wells (26) and layers (12, 14, 16, 18) are interconnected through microfluidic channels (28). A process for fabricating the three-dimensional device and a method for depositing different types of cells within the device in a functional interdependent spatial orientation thereby mimicking physiological functions. The device is useful for diagnostic assays, determination of dysfunction of certain cells in the system, quantification of production of cellular proteins, metabolites, hormones or other cellular products, for organ or tissue replacement, for co-culturing different cells, for testing pharmaceutical agents and as a bioreactor for production of biologicals.
摘要翻译：用于相同或不同类型的单元的三维空间定位和功能互连的装置（10），方法和过程。包含多个层（12,14,16,18）的二维或三维装置（10）包含用于细胞沉积的孔（26），其中孔（26）和层（12,14,16,18）都互连通过微流体通道（28）。用于制造三维装置的方法和用于在功能相互依赖的空间取向中在装置内沉积不同类型的细胞的方法，从而模仿生理功能。该装置可用于诊断测定，确定系统中某些细胞的功能障碍，定量细胞蛋白质，代谢物，激素或其他细胞产物的生成，用于器官或组织置换，用于共培养不同细胞，用于测试药剂并作为生物反应器的生物反应器。

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