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1. 发明申请

WO2012074117A1 EFFICIENT METHOD FOR ESTABLISHING ARTIFICIAL PLURIPOTENT STEM CELLS 审中-公开
标题翻译：用于建立人工细胞干细胞的有效方法
公开(公告)号：WO2012074117A1
公开(公告)日：2012-06-07
申请号：PCT/JP2011077992
申请日：2011-12-02
申请人： UNIV KYOTO , YAMANAKA SHINYA , TAKAHASHI KAZUTOSHI , TANABE KOJI
发明人： YAMANAKA SHINYA , TAKAHASHI KAZUTOSHI , TANABE KOJI
IPC分类号： C12N5/10 , C12N15/09
CPC分类号： C12N5/0696 , C12N15/85 , C12N2501/115 , C12N2501/415 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/998 , C12N2506/1307 , C12N2510/00
摘要： The present invention provides a method for improving the efficiency of establishing artificial pluripotent stem cells, said method including, in a step for nucleus initialization of somatic cells, causing an increase in the level of activity of at least one protein selected from the group consisting of a Ras family member, a PI3 kinase, RalGEF, Raf, an AKT family member, Rheb, TCL1, and S6K. The present invention also provides an agent for improving the efficiency of establishing artificial pluripotent stem cells, said agent comprising a factor selected from the group consisting of a Ras family member, a PI3 kinase, RalGEF, Raf, an AKT family member, Rheb, TCL1, S6K, and nucleic acids coding for each of same. Furthermore, the present invention provides a method for producing artificial pluripotent stem cells, said method including causing somatic cells to contact a nucleus initialization substance and at least one factor selected from the group consisting of a Ras family member, a PI3 kinase, RalGEF, Raf, an AKT family member, Rheb, TCL1, S6K, and nucleic acids coding for each of same.
摘要翻译：本发明提供了一种提高人造多能干细胞建立效率的方法，所述方法包括在体细胞核初始化步骤中引起至少一种蛋白质的活性水平的提高，所述蛋白质选自 Ras家族成员，PI3激酶，RalGEF，Raf，AKT家族成员，Rheb，TCL1和S6K。本发明还提供了用于提高建立人造多能干细胞的效率的试剂，所述试剂包含选自Ras家族成员，PI3激酶，RalGEF，Raf，AKT家族成员，Rheb，TCL1的因子，S6K和编码其中每一种的核酸。此外，本发明提供了一种生产人造多能干细胞的方法，所述方法包括使体细胞接触核初始化物质和至少一种选自Ras家族成员，PI3激酶，RalGEF，Raf ，AKT家族成员，Rheb，TCL1，S6K和编码其中每一种的核酸。

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