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1. 发明申请

WO2008067386A3 PIEZOELECTRIC MICROCANTILEVER SENSORS FOR BIOSENSING 审中-公开
标题翻译：用于生物传感的压电微型传感器
公开(公告)号：WO2008067386A3
公开(公告)日：2008-07-17
申请号：PCT/US2007085771
申请日：2007-11-28
申请人： UNIV DREXEL , SHIH WAN Y , SHIH WEI-HENG , SHEN ZUYAN , MCGOVERN JOHN-PAUL , ZHU QING , CAPOBIANCO JOSEPH
发明人： SHIH WAN Y , SHIH WEI-HENG , SHEN ZUYAN , MCGOVERN JOHN-PAUL , ZHU QING , CAPOBIANCO JOSEPH
IPC分类号： G01N5/02 , B81B3/00
CPC分类号： G01N29/022 , B82Y5/00 , B82Y35/00 , G01N29/036 , G01N29/245 , G01N33/54306 , G01N33/57415 , G01N2291/0255 , G01N2291/0256 , G01N2291/0257 , G01N2291/0427
摘要： A piezoelectric microcantilever for sensing compounds or molecules. The piezoelectric microcantilever, may include at least one electrode, an insulation layer, a receptor, an immobilization layer, a non-piezoelectric layer and a piezoelectric layer The sensor is capable of self actuation and detection. The piezoelectric layer may be constructed from a highly piezoelectric thin lead magnesium niobate-lead titanate film, a highly piezoelectric thin zirconate titanate film, a highly piezoelectric lead-free film. Methods of using the sensors and flow cells and arrays including the sensors are also described.
摘要翻译：用于感应化合物或分子的压电微悬臂梁。压电微悬臂梁可以包括至少一个电极，绝缘层，接收器，固定层，非压电层和压电层。传感器能够自行致动和检测。压电层可以由高压电薄膜铌酸铅 - 钛酸铅薄膜，高压电薄钛酸锆薄膜，高压电无铅薄膜构成。还描述了使用传感器和包括传感器的流动池和阵列的方法。

2. 发明申请

WO2008058121A3 SOL-GEL PRECURSORS AND METHODS FOR MAKING LEAD-BASED PEROVSKITE FILMS 审中-公开
标题翻译： SOL-凝胶前体和制备基于铅的钙钛矿薄膜的方法
公开(公告)号：WO2008058121A3
公开(公告)日：2008-09-25
申请号：PCT/US2007083767
申请日：2007-11-06
申请人： UNIV DREXEL , SHIH WEI-HENG , SHIH WAN Y , SHEN ZUYAN , LI HUIDONG , GAO XIAOTONG
发明人： SHIH WEI-HENG , SHIH WAN Y , SHEN ZUYAN , LI HUIDONG , GAO XIAOTONG
IPC分类号： C04B41/45 , C04B41/50
CPC分类号： H01L41/318 , H01L41/094 , H01L41/0973 , H01L41/1875
摘要： A simple, economical sol-gel method was invented to produce thick and dense lead zirconate titanate (PZT) thin films that exhibit the stoichiometric chemical composition and unprecedented electrical and dielectric properties. The PZT films are the foundation of many microelectromechanical systems (MEMS) and nanoelectromechanical systems (NEMS) for micro/nano sensors and actuators applications.
摘要翻译：发明了一种简单，经济的溶胶 - 凝胶方法来生产厚而致密的锆钛酸铅（PZT）薄膜，其表现出化学计量的化学组成和前所未有的电和介电性能。 PZT薄膜是许多用于微/纳米传感器和致动器应用的微机电系统（MEMS）和纳机电系统（NEMS）的基础。

3. 发明申请

WO2008058121A9 SOL-GEL PRECURSORS AND METHODS FOR MAKING LEAD-BASED PEROVSKITE FILMS 审中-公开
标题翻译： SOL-GEL前身和制备基于铅的PEROVSKITE膜的方法
公开(公告)号：WO2008058121A9
公开(公告)日：2008-07-31
申请号：PCT/US2007083767
申请日：2007-11-06
申请人： UNIV DREXEL , SHIH WEI-HENG , SHIH WAN Y , SHEN ZUYAN , LI HUIDONG , GAO XIAOTONG
发明人： SHIH WEI-HENG , SHIH WAN Y , SHEN ZUYAN , LI HUIDONG , GAO XIAOTONG
IPC分类号： C04B41/45 , C04B41/50
CPC分类号： H01L41/318 , H01L41/094 , H01L41/0973 , H01L41/1875
摘要： A simple, economical sol-gel method was invented to produce thick and dense lead zirconate titanate (PZT) thin films that exhibit the stoichiometric chemical composition and unprecedented electrical and dielectric properties. The PZT films are the foundation of many microelectromechanical systems (MEMS) and nanoelectromechanical systems (NEMS) for micro/nano sensors and actuators applications.
摘要翻译：发明了一种简单经济的溶胶 - 凝胶法，以生产厚而致密的锆钛酸铅（PZT）薄膜，其表现出化学计量的化学成分和前所未有的电和介电性能。 PZT薄膜是用于微/纳米传感器和致动器应用的许多微机电系统（MEMS）和纳米机电系统（NEMS）的基础。

4. 发明申请

WO2005043126A3 PIEZOELECTRIC CANTILEVER SENSORS 审中-公开
标题翻译：压电式CANTILEVER传感器
公开(公告)号：WO2005043126A3
公开(公告)日：2005-08-04
申请号：PCT/US2004036705
申请日：2004-10-27
申请人： UNIV DREXEL , SHIH WAN Y , SHIH WEI-HENG , SHEN ZUYAN
发明人： SHIH WAN Y , SHIH WEI-HENG , SHEN ZUYAN
IPC分类号： G01N20060101 , G01N1/00 , G01N29/02 , G01N29/036
CPC分类号： G01N29/022 , G01N5/02 , G01N29/036 , G01N2291/0255 , G01N2291/0256 , G01N2291/02818 , G01N2291/0422 , G01N2291/0426 , G01N2291/0427
摘要： A piezoelectric cantilever with a non-piezoelectric, or piezoelectric tip useful as mass and viscosity sensors. The change in the cantilever mass can be accurately quantified by monitoring a resonance frequency shift of the cantilever. For bio-detection, antibodies or other specific receptors of target antigens may be immobilized on the cantilever surface, preferably on the non-piezoelectric tip. For chemical detection, high surface-area selective absorbent materials are coated on the cantilever tip. Binding of the target antigens or analytes to the cantilever surface increases the cantilever mass. Detection of target antigens or analytes is achieved by monitoring the cantilever's resonance frequency and determining the resonance frequency shift that is due to the mass of the adsorbed target antigens on the cantilever surface. The use of a piezoelectric unimorph cantilever allows both electrical actuation and electrical sensing. Incorporating a non-piezoelectric tip (14) enhances the sensitivity of the sensor. In addition, the piezoelectric cantilever can withstand damping in highly viscous liquids and can be used as a viscosity sensor in wide viscosity range.
摘要翻译：具有非压电或压电尖端的压电悬臂，可用作质量和粘度传感器。通过监测悬臂的共振频率偏移可以准确量化悬臂质量的变化。为了生物检测，靶抗原的抗体或其他特异性受体可以固定在悬臂表面上，优选地固定在非压电尖端上。对于化学检测，高表面积选择性吸收材料涂覆在悬臂尖端。目标抗原或分析物与悬臂表面的结合增加了悬臂质量。通过监测悬臂的共振频率并确定由于悬臂表面上吸附的靶抗原的质量而引起的共振频移，实现了靶抗原或分析物的检测。使用压电单块悬臂可以实现电致动和电感测。结合非压电尖端（14）增强了传感器的灵敏度。此外，压电悬臂可以承受高粘度液体中的阻尼，可用作宽粘度范围内的粘度传感器。

5. 发明申请

WO2009126378A3 ENHANCED DETECTION SENSITIVITY WITH PIEZOELECTRIC MICROCANTILEVER SENSORS 审中-公开
标题翻译：用压电微型传感器增强检测灵敏度
公开(公告)号：WO2009126378A3
公开(公告)日：2009-12-03
申请号：PCT/US2009036048
申请日：2009-03-04
申请人： UNIV DREXEL , SHIH WAN Y , SHIH WEI-HENG , ZHU QING
发明人： SHIH WAN Y , SHIH WEI-HENG , ZHU QING
IPC分类号： B81B3/00
CPC分类号： G01N29/2437 , G01N29/036 , G01N33/54373 , G01N2291/0257
摘要： A method for enhancing the detection sensitivity of a piezoelectric microcantilever sensor. The method may involve providing a piezoelectric microcantilever and inducing a change in the Young's modulus during detection of a species of interest. The change in the Young's modulus may be induced or enhanced by the application of a DC bias electric field to the piezoelectric layer that enhances non-180° polarization domain switching of the piezoelectric layer. The change in the Young's modulus may also result from binding of the species of interest to the piezelectric microcantilever sensor or a combination of binding and application of a DC bias electric field. Significantly enhanced detection sensitity results from the changed Young's modulus of the piezoelectric layer.
摘要翻译：一种提高压电微悬臂梁传感器检测灵敏度的方法。该方法可以包括提供压电微悬臂梁并在感兴趣的物种的检测期间引起杨氏模量的变化。杨氏模量的变化可以通过向压电层施加直流偏压电场而引起或增强，这增强了压电层的非180°极化域切换。杨氏模量的变化也可能是由感兴趣的物质与压电介质微悬臂梁传感器的结合或直流偏置电场的结合和施加的组合引起的。由压电层的杨氏模量的变化引起的检测敏感度显着提高。

6. 发明申请

WO2013066408A3 CLEAR MARGIN DETERMINATION DURING CANCER SURGERY 审中-公开
标题翻译：癌症手术期间清除肿瘤的确定
公开(公告)号：WO2013066408A3
公开(公告)日：2013-06-27
申请号：PCT/US2012039532
申请日：2012-05-25
申请人： UNIV DREXEL , PHILADELPHIA HEALTH & EDUCATIO , SHIH WEI-HENG , SHIH WAN Y , AU GIANG , BROOKS ARI D , SWAMI VANLILA K
发明人： SHIH WEI-HENG , SHIH WAN Y , AU GIANG , BROOKS ARI D , SWAMI VANLILA K
IPC分类号： G01N33/532 , B82Y15/00 , G01N21/63 , G01N33/574
CPC分类号： G01N33/57488 , B82Y5/00 , B82Y15/00 , B82Y40/00 , C07K16/22 , C07K16/30 , G01N33/532 , G01N33/533 , G01N33/574 , G01N33/57484 , G01N33/57492 , G01N33/588 , G01N2333/475 , G01N2333/705 , G01N2400/00 , G01N2458/00 , Y10S977/774 , Y10S977/824 , Y10S977/892 , Y10S977/927
摘要： One or more aqueous, near infrared emitting, high yield, highly photoluminescent, stable quantum dots conjugated to one or more biomarkers specific moieties. The conjugated quantum dots have an enhanced detection sensitivity and selectivity and may be formed using a novel and efficient method for conjugating one or more biomarker specific moieties to the quantum dots. The invention is further directed to a method for using the conjugated quantum dots for cancer detection in the margin of excised tissue.
摘要翻译：与一个或多个生物标志物特异性部分缀合的一种或多种水性近红外发射的高产率高度光致发光的稳定的量子点。共轭量子点具有增强的检测灵敏度和选择性，并且可以使用用于将一个或多个生物标记特异性部分缀合到量子点的新颖且有效的方法形成。本发明还涉及一种在切除组织边缘使用共轭量子点进行癌症检测的方法。

7. 发明申请

WO2009140660A3 SYSTEM AND METHOD FOR EVALUATING TISSUE 审中-公开
标题翻译：用于评估组织的系统和方法
公开(公告)号：WO2009140660A3
公开(公告)日：2010-03-04
申请号：PCT/US2009044250
申请日：2009-05-15
申请人： UNIV DREXEL , PHILADELPHIA HEALTH & EDUCATIO , SHIH WAN Y , SHIH WEI-HENG , YEGINGIL HAKKI , BROOKS ARI D
发明人： SHIH WAN Y , SHIH WEI-HENG , YEGINGIL HAKKI , BROOKS ARI D
IPC分类号： G01N33/483 , C12Q1/02
CPC分类号： A61B5/0053 , A61B5/4244 , A61B5/4312 , A61B5/4381 , A61B5/441 , A61B5/442 , A61B8/085 , A61B8/403 , A61B8/485 , G01N29/0672 , G01N2291/02475 , G01N2291/02827
摘要： A sensor system for measuring an elastic modulus and a shear modulus and a method for evaluating a tissue. The invention pertains to a method for determining the presence of and/or characterizing abnormal growths, using a piezoelectric finger sensor (PEFS) system. The PEFS system may be particularly useful for screening for tumors and various forms of cancer. Additionally, the PEFS system may be useful for various dermatological applications.
摘要翻译：用于测量弹性模量和剪切模量的传感器系统和用于评估组织的方法。本发明涉及使用压电手指传感器（PEFS）系统确定异常生长的存在和/或表征异常生长的方法。 PEFS系统可能特别适用于筛选肿瘤和各种形式的癌症。此外，PEFS系统可用于各种皮肤病学应用。

8. 发明申请

WO2009079154A3 LEAD-FREE PIEZOELECTRIC CERAMIC FILMS AND A METHOD FOR MAKING THEREOF 审中-公开
标题翻译：无铅压电陶瓷膜及其制造方法
公开(公告)号：WO2009079154A3
公开(公告)日：2009-10-22
申请号：PCT/US2008084190
申请日：2008-11-20
申请人： UNIV DREXEL , SHIH WEI-HENG , SHIH WAN Y , LI HUIDONG
发明人： SHIH WEI-HENG , SHIH WAN Y , LI HUIDONG
IPC分类号： H01L41/187
CPC分类号： G01N27/12 , H01L41/1873 , H01L41/314 , H01L41/43
摘要： This invention relates to lead-free piezoelectric ceramic films and a method of making thereof. Specifically, the invention is directed to a method for fabricating lead-free piezoelectric free standing films having enhanced piezoelectric properties. The films may be used for a number of applications including incorporation in microelectronic devices such as energy harvesting devices and sesor technologies.
摘要翻译：本发明涉及无铅压电陶瓷膜及其制造方法。具体而言，本发明涉及制造具有增强的压电性能的无铅压电独立膜的方法。这些薄膜可用于许多应用，包括纳入微电子器件如能量收集器件和吸收技术。

9. 发明申请

WO2009046251A3 SPECIFICITY AND SENSITIVITY ENHANCEMENT IN PIEZOELECTRIC CANTILEVER SENSING 审中-公开
标题翻译：压电悬臂梁传感器的特异性和灵敏度增强
公开(公告)号：WO2009046251A3
公开(公告)日：2009-08-13
申请号：PCT/US2008078675
申请日：2008-10-03
申请人： UNIV DREXEL , SHIH WEI-HENG , SHIH WAN Y
发明人： SHIH WEI-HENG , SHIH WAN Y
IPC分类号： G01N33/533
CPC分类号： G01N33/54373
摘要： The invention is directed to a sensor system including at least one sensor and target specific receptors bound substrates for purposes of enhancing detection sensitivity. Optionally, the sensor system may include quantum dots for independently verifying the presence of a target molecule or compound. The sensor system may be particularly beneficial in the field of medical diagnostics, bio-defense, food safety, water safety and general chemical detection.
摘要翻译：本发明涉及一种传感器系统，其为了提高检测灵敏度而包括至少一个传感器和目标特异性受体结合的基底。可选地，传感器系统可以包括用于独立验证靶分子或化合物的存在的量子点。传感器系统在医疗诊断，生物防御，食品安全，水安全和一般化学检测领域可能特别有益。

10. 发明申请

WO2008121429A3 ENERGY HARVESTING DEVICE 审中-公开
标题翻译：能量采集设备
公开(公告)号：WO2008121429A3
公开(公告)日：2009-05-28
申请号：PCT/US2008052292
申请日：2008-01-29
申请人： UNIV DREXEL , SHIH WEI-HENG , SHIH WAN Y , YEGINGIL HAKKI
发明人： SHIH WEI-HENG , SHIH WAN Y , YEGINGIL HAKKI
IPC分类号： H02N2/18 , H01L41/08
CPC分类号： H01L41/1136 , H01L41/1875 , H02N2/188
摘要： A piezoelectric energy harvesting device (PEHD) comprising a driving element, conducting element, piezoelectric layer and non-piezoelectric layer capable of converting ambient mechanical energy into electrical energy. The piezoelectric layer may be constructed from PMN-PT or PZT having a thickness of about 1-150 ?m. The PEHD may be used to generate about 1 W. The harvested energy may be stored and used to power microelectronic devices and rechargeable battery technologies.
摘要翻译：一种压电能量收集装置（PEHD），包括能够将环境机械能转换为电能的驱动元件，导电元件，压电层和非压电层。压电层可以由具有约1-150μm的厚度的PMN-PT或PZT构成。 PEHD可用于产生约1W。收获的能量可以被存储并用于为微电子器件和可充电电池技术供电。

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