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1. 发明申请

WO2015056216A3 PEPTIDE COMPOSITION AND USES THEREOF 审中-公开
标题翻译：肽组合物及其用途
公开(公告)号：WO2015056216A3
公开(公告)日：2015-11-12
申请号：PCT/IB2014065375
申请日：2014-10-16
申请人： UNIV DO MINHO
发明人： CAVACO PAULO ARTUR MANUEL , FREITAS DA CRUZ CÉLIA , MACEDO FRANCESKO FERNANDES MARGARIDA MARIA
IPC分类号： A61K8/64 , A61Q5/00 , A61Q5/04 , A61Q5/06
CPC分类号： A61K8/64 , A61K8/645 , A61K2800/30 , A61Q5/002 , A61Q5/04 , A61Q5/06 , A61Q5/065
摘要： The present application relates to a composition comprising at least one peptide with a size of 6-12 amino acids, wherein 2-5 of said amino acids are cysteines, which can be used for treatment and grooming products for animal hair, preferably for treatment and cosmetics for human hair. Several methods are available for styling hair which involve breaking and re-establishing new disulphide bonds, allowing the hair to be relaxed and straightened. However, the currently more effective methods for styling hair use harmful chemical products. There is therefore a continuing need for formulations that can be used for effectively styling hair fibres without damaging same. The present invention therefore intends to provide a composition for treating animal hair, including human hair, without the use of chemicals that are harmful to hair fibres and to the health of the user, and uses of said compositions as a shampoo, lotion, serum, cream, conditioner, foam, elixir, oil, aerosol or mask.
摘要翻译：本申请涉及包含至少一种大小为6-12个氨基酸的肽的组合物，其中2-5个所述氨基酸为半胱氨酸，其可用于动物毛发的处理和修饰产品，优选用于治疗和用于人发的化妆品。有几种方法可用于造型头发，包括打破和重新建立新的二硫键，使头发放松和矫直。但是，目前更有效的头发造型方法使用有害的化学产品。因此，持续需要可用于有效定型头发纤维而不损伤头发纤维的配方。因此，本发明旨在提供一种用于处理包括人发在内的动物毛发的组合物，而不使用对头发纤维有害并且对使用者健康有害的化学物质，并且所述组合物用作香波，洗剂，血清，面霜，护发素，泡沫，酏剂，油，气雾剂或面膜。

2. 发明申请

WO2013084208A3 LIPOSOMES AND CORRESPONDING PRODUCTION METHOD 审中-公开
标题翻译：脂质体和相应的生产方法
公开(公告)号：WO2013084208A3
公开(公告)日：2013-11-07
申请号：PCT/IB2012057083
申请日：2012-12-07
申请人： UNIV DO MINHO
发明人： CAVACO PAULO ARTUR MANUEL , LOPES PRETO DE ALMEIDA ANA ARMINDA , DA COSTA NOGUEIRA EUGENIA SOFIA , FERREIRA CASTRO GOMES ANDREIA
IPC分类号： A61K47/48 , A61K9/127
CPC分类号： A61K47/48815 , A61K9/1271 , A61K47/551 , A61K47/6911 , C12N15/113
摘要： The present invention describes the use of conjugated peptide sequences enclosed in liposome membranes. Conjugation can be with a folic acid or an antibody of the folic acid receptor, which is coupled to the N-terminal of the peptide. The presence of these conjugated peptides in liposome formulations allows therapeutic agents and/or imaging agents to be specifically targetted to and subsequently released in cells with expression of folic acid receptors. The thus developed method allies the capacity of liposomes to transport and release drugs with the specific expression of receptors at the surface of cell membranes, allowing transmembrane transport mediated by specific liposomes. It thus can transport both hydrophobic and hydrophilic therapeutic and/or imaging agents inside the liposome. The therapeutic agents can be pharmacological compounds - active principles - or small interfering RNAs (siRNAs) specific to defined target genes.
摘要翻译：本发明描述了封闭在脂质体膜中的缀合肽序列的用途。缀合可以是叶酸或叶酸受体的抗体，其与肽的N末端偶联。这些缀合的肽在脂质体制剂中的存在使得治疗剂和/或显像剂特异性靶向并随后在具有叶酸受体表达的细胞中释放。这样开发的方法结合脂质体运输和释放具有细胞膜表面受体特异性表达的药物的能力，允许由特定脂质体介导的跨膜转运。因此，它可以在脂质体内输送疏水和亲水的治疗和/或成像剂。治疗剂可以是对定义的靶基因特异性的药理化合物 - 活性原理或小干扰RNA（siRNA）。

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