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1. 发明申请

WO2009097539A2 SYSTEMS, DEVICES, AND METHODS FOR ROBOT-ASSISTED MICRO-SURGICAL STENTING 审中-公开
标题翻译：机器人辅助微创手术的系统，设备和方法
公开(公告)号：WO2009097539A2
公开(公告)日：2009-08-06
申请号：PCT/US2009032657
申请日：2009-01-30
申请人： UNIV COLUMBIA , SIMAAN NABIL , FINE HOWARD , WEI WEI , CHANG STANLEY
发明人： SIMAAN NABIL , FINE HOWARD , WEI WEI , CHANG STANLEY
IPC分类号： A61B17/34 , A61F2/82
CPC分类号： A61F2/82 , A61B34/30 , A61B34/37 , A61B34/71 , A61B34/77 , A61B2017/00331 , A61B2017/00345 , A61B2017/00991 , A61B2034/304 , A61B2090/064 , A61F2/966 , A61F9/007
摘要： Systems, devices, and methods for robot-assisted microsurgical stenting are described herein. In some embodiments a tele-robotic microsurgical system for eye surgery include: a tele- robotic master and a slave hybrid-robot; wherein the tele-robotic master has at least one master slave interface controlled by a medical professional; wherein the slave hybrid-robot has at least one robotic arm attached to a frame releasably attached to a patient's head; wherein the at least one robotic arm has a parallel robot and a serial robot; and wherein the serial robot includes a stenting unit which includes a support tube, a pre-bent tube mounted within the support tube and a guide wire extending from the support tube for carrying a stent and for piercing a blood vessel.
摘要翻译：本文描述了用于机器人辅助显微外科支架置入术的系统，装置和方法。在一些实施例中，用于眼科手术的远程机器人显微外科系统包括：远程机器人主机和从属混合机器人; 其中远程机器人主机具有由医疗专业人员控制的至少一个主从接口; 其中所述从动混合机器人具有附接到可释放地附接到患者头部的框架的至少一个机器人手臂; 其中所述至少一个机器臂具有并联机器人和串行机器人; 并且其中所述串联机器人包括支架单元，所述支架单元包括支撑管，安装在所述支撑管内的预弯曲管和从所述支撑管延伸以用于承载支架和用于刺穿血管的导丝。

2. 发明申请

WO2005066363A3 CANCER SPECIFIC GENE CCNDBP1 审中-公开
标题翻译：癌症特异基因CCNDBP1
公开(公告)号：WO2005066363A3
公开(公告)日：2005-11-03
申请号：PCT/GB2005000042
申请日：2005-01-07
申请人： MEDIGEN BIOTECHNOLOGY CORP , CREASE DEVANAND JOHN , CHANG STANLEY , CHANG HSUN-LANG , KUO WEI-YING , CHEN KUO-YEN , LI NING-YI
发明人： CHANG STANLEY , CHANG HSUN-LANG , KUO WEI-YING , CHEN KUO-YEN , LI NING-YI
IPC分类号： C07H21/04 , C07K14/47 , C07K16/30 , C07K16/32 , C12Q1/68 , G01N33/574
CPC分类号： C07H21/04 , C07K16/32 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/178 , G01N33/57484
摘要： CCNDBP1 is identified as an oncogene. Methods and compositions for detecting an diagnosing cancer in patients are provided, by determining the level of MG20 e pression in biological samples. Also provided are methods for screening for inY: bitors and moderators of MG20 expression and activity, as well as compositions comprising compounds and molecules that inhibit or moderate MG20 expression or activity, thereby treating cancer, MG20 (CCNDBPI) is identified as an oncogene. Methods and compositions for detecting and diagnosing cancer in patients are provided, by determining the level of MG20 expression in biological samples. Also provided are methods for screening for inhibitors and moderators of MG20 expression and activity, as well as compositions comprising compounds and molecules that inhibitor moderate MG20 expression or activity, thereby treating cancer, in vivo in vivo .
摘要翻译： CCNDBP1被鉴定为癌基因。通过确定生物样品中MG20 e的水平来提供检测患者诊断癌症的方法和组合物。还提供了用于筛选inY：MG20表达和活性的比特和调节剂的方法，以及包含抑制或中和MG20表达或活性，从而治疗癌症的化合物和分子的组合物，MG20（CCNDBPI）被鉴定为癌基因。通过确定生物样品中MG20表达水平，提供了检测和诊断患者癌症的方法和组成。还提供了筛选MG20表达和活性的抑制剂和调节剂的方法，以及包含抑制中度MG20表达或活性，从而治疗癌症的化合物和分子的组合物，鉴定为癌基因。通过确定生物样品中MG20表达水平，提供了检测和诊断患者癌症的方法和组成。还提供了筛选MG20表达和活性的抑制剂和调节剂的方法，以及包含抑制或中和MG20表达或活性的化合物和分子的组合物，从而在体内治疗癌症.GG20（CCNDBPI）被鉴定为癌基因。通过确定生物相容性的MG20表达水平，提供了患者癌症检测和诊断的方法和组成。还提供筛选MG抑制剂和调节剂的方法。表达和活性，以及包含抑制或中和MG20表达或活性的化合物和分子的组合物，从而治疗癌症，体内

3. 发明申请

WO2010077617A2 DEVICE AND METHOD FOR INTRANASAL DELIVERY 审中-公开
标题翻译：用于手工输送的装置和方法
公开(公告)号：WO2010077617A2
公开(公告)日：2010-07-08
申请号：PCT/US2009067030
申请日：2009-12-07
申请人： CHANG STANLEY , CHEN MICHAEL
发明人： CHANG STANLEY , LAI KUAN-LANG
IPC分类号： A61M35/00 , A61F13/02 , A61L27/14 , A61L27/54
CPC分类号： A61M31/002
摘要： The present invention provides a method and device for for producing a mucosal response in a subject in need thereof through nasal route, particularly in the treatment of a disease or disorder in respiratory tracts, such as allergen-induced airway inflammation, which is more easily operated and efficient in absorption than conventional methods. The device of the invention comprises a nasal clip containing first and second opposed portions for releasably gripping the nasal septum of the subject to retain said clip therein, and means for loading a mixture of an allergen and a pharmaceutically acceptable carrier at the ends of the first and second opposed portions, wherein the means for loading a mixture of an active ingredient and a pharmaceutically acceptable carrier contact the nasal mucosa of the subject.
摘要翻译：本发明提供了一种用于在有需要的受试者中通过鼻道产生粘膜应答的方法和装置，特别是用于治疗呼吸道疾病或病症如变应原诱发的气道炎症，其更容易操作并且比常规方法高效吸收。本发明的装置包括一个鼻夹，其包含第一和第二相对部分，用于可释放地夹持受试者的鼻隔膜以将所述夹子保持在其中，以及用于将第一和第二部分末端的变应原和药学上可接受的载体的混合物装载的装置和第二相对部分，其中用于装载活性成分和药学上可接受载体的混合物的装置接触受试者的鼻粘膜。

4. 发明申请

WO2007122380A3 MEDICAL SYSTEM AND METHOD FOR DETERMINING PARAMETERS 审中-公开
标题翻译：用于确定参数的医疗系统和方法
公开(公告)号：WO2007122380A3
公开(公告)日：2008-08-14
申请号：PCT/GB2007001363
申请日：2007-04-13
申请人： ACM MEDICAL TECHNOLOGIES INC , CREASE DEVANAND JOHN , LIN ALEX CHUN CHING , CHANG STANLEY , CHANG WEI-KUO
发明人： LIN ALEX CHUN CHING , CHANG STANLEY , CHANG WEI-KUO
IPC分类号： A61B10/00
CPC分类号： A61B10/0045 , A61B5/0059 , A61B2010/0061 , A61B2560/0406 , A61B2560/0425 , A61B2560/0456 , G01N21/4133 , G01N21/8483 , G01N33/558 , G01N2201/0221 , G01N2800/06
摘要： The present invention discloses a device or system, and the method thereof, for determining gastrointestinal parameters with the reference database saved equations for calculating the parameters comprising concentration of dietary formula, the gastric residual volume, the amount of dietary formula retained in the stomach, and volume of dietary formula remaining in stomach.
摘要翻译：本发明公开了一种装置或系统及其方法，用于使用参考数据库保存的方程来确定胃肠参数，用于计算包括饮食配方的浓度，胃残留体积，保留在胃中的膳食配方的量的参数，以及饮食习惯体积在胃里。

5. 发明申请

WO2005084109A3 CANCER SPECIFIC GENE MH15 审中-公开
标题翻译：癌症特异基因MH15
公开(公告)号：WO2005084109A3
公开(公告)日：2006-04-20
申请号：PCT/GB2005000858
申请日：2005-03-07
申请人： MEDIGEN BIOTECHNOLOGY CORP , CREASE DEVANAND JOHN , CHANG STANLEY , CHANG HSUN-LANG , KUO WEI-YING , CHEN KUO-YEN , LI NING-YI , HSU CHIH-PING , HO PEI-HSUN
发明人： CHANG STANLEY , CHANG HSUN-LANG , KUO WEI-YING , CHEN KUO-YEN , LI NING-YI , HSU CHIH-PING , HO PEI-HSUN
IPC分类号： C12Q1/68 , C07K16/30 , G01N33/53 , G01N33/574
CPC分类号： G01N33/5748 , C07K16/30 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： MH15 (Hn1L) is identified as an oncogene. Methods and compositions for detecting and diagnosing cancer in patients are provided, by determining the level of MH15 expression in biological samples. Also provided are methods for screening for inhibitors and moderators of MH15 expression and activity, as well as compositions comprising compounds and molecules that inhibit or moderate MH15 expression or activity, thereby treating cancer, in vivo.
摘要翻译： MH15（Hn1L）被鉴定为癌基因。通过确定生物样品中MH15表达的水平，提供了检测和诊断患者癌症的方法和组合物。还提供了用于筛选MH15表达和活性的抑制剂和调节剂的方法，以及包含抑制或抑制MH15表达或活性，从而在体内治疗癌症的化合物和分子的组合物。

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