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1. 发明申请

WO2008112278A3 METHODS AND COMPOSITIONS FOR MODULATING INSULIN SECRETION AND GLUCOSE METABOLISM 审中-公开
标题翻译：用于调节胰岛素分泌和葡萄糖代谢的方法和组合物
公开(公告)号：WO2008112278A3
公开(公告)日：2008-11-20
申请号：PCT/US2008003338
申请日：2008-03-12
申请人： UNIV COLUMBIA , HARRIS PAUL , XIE YULI , LANDRY DONALD , DENG SHI-XIAN , MAFFEI ANTONELLA
发明人： HARRIS PAUL , XIE YULI , LANDRY DONALD , DENG SHI-XIAN , MAFFEI ANTONELLA
IPC分类号： A01N43/62 , A61K31/70
CPC分类号： A61K31/473 , A61K31/00 , A61K31/05 , A61K31/4741 , A61K31/4745 , A61K31/475
摘要： The present invention relates to methods and compositions for treating or ameliorating the effects of diabetes. In addition, the present invention relates to methods and compositions for treating or preventing hyperglycemia, as well as modulating monoamine levels, islet ß-cell insulin secretion, insulin and/or glucagon levels in a patient. In certain preferred embodiments, such methods include administering to a patient an effective amount of a vesicular monoamine transporter type 2 (VMAT2) antagonist, such as tetrabenazine (TBZ), dihydrotetrabenazine (DTBZ), tetrahydroberberine (THB), reserpine, emetine, Compound 6, or enantiomers, optical isomers, diastereomers, N-oxides, crystalline forms, hydrates, metabolites or pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及用于治疗或改善糖尿病的作用的方法和组合物。此外，本发明还涉及用于治疗或预防高血糖的方法和组合物，以及调节患者体内单胺水平，胰岛β细胞胰岛素分泌，胰岛素和/或胰高血糖素水平。在某些优选的实施方案中，这些方法包括向患者施用有效量的2型（VMAT2）囊泡单胺转运蛋白拮抗剂，如丁苯那嗪（TBZ），二氢丁苯那嗪（DTBZ），四氢小檗碱（THB），利血平，，或对映体，旋光异构体，非对映异构体，N-氧化物，结晶形式，水合物，代谢物或药学上可接受的盐。

2. 发明申请

WO2007005283A3 USE OF DTBZ FOR IMAGING ENDOCRINE PANCREAS AND BETA CELL MASS IN TYPE 1 DIABETES 审中-公开
标题翻译： DTBZ用于1型糖尿病内分泌腺和胰岛β细胞的成像
公开(公告)号：WO2007005283A3
公开(公告)日：2007-03-22
申请号：PCT/US2006024049
申请日：2006-06-21
申请人： UNIV COLUMBIA , HARRIS PAUL , MAFFEI ANTONELLA
发明人： HARRIS PAUL , MAFFEI ANTONELLA
IPC分类号： A61K49/00 , A61K51/00
CPC分类号： A61K51/0455
摘要： The present invention provides non-invasive methods for determining the beta cell mass in the pancreas of a subject by administering to the subject an effective amount of a vesicular monoamine transporter type 2 (VMAT2)-specific radioligand; obtaining at least one computerized image of at least a portion of the pancreas of the subject; and quantitatively analyzing the computerized image in order to determine the beta cell mass in the pancreas of the subject. The present invention additionally provides methods for diagnosing a metabolic neuroendocrine disorder in a subject including insulinoma, diabetes and preclinical diabetes, as well as methods for determining the efficacy of treatment for a metabolic disorder. The present invention further provides methods for assessing the prognosis of a subject at risk for developing diabetes, and methods for managing the treatment or prevention of diabetes. The present invention also provides kits for use in determining the beta cell mass in the pancreas of a subject, as well as diagnosing metabolic or neuroendocrine disorders in a subject.
摘要翻译：本发明提供了通过向受试者施用有效量的泡状单胺转运蛋白2型（VMAT2）特异性放射性配体来确定受试者胰腺中β细胞量的非侵入性方法; 获得对象的至少一部分胰腺的至少一个计算机化图像; 并定量分析计算机化图像以确定受试者胰腺中的β细胞量。本发明另外提供了用于诊断受试者中的代谢性神经内分泌紊乱的方法，所述紊乱包括胰岛瘤，糖尿病和临床前糖尿病，以及用于确定治疗代谢紊乱的功效的方法。本发明进一步提供了评估处于发展糖尿病风险中的受试者的预后的方法，以及用于管理糖尿病的治疗或预防的方法。本发明还提供用于测定受试者胰腺中的β细胞量以及诊断受试者中的代谢或神经内分泌紊乱的试剂盒。

3. 发明申请

WO2012103300A3 POLYPEPTIDES HAVING CELLOBIOHYDROLASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有纤维二糖水解酶活性的多肽和编码该多肽的多核苷酸
公开(公告)号：WO2012103300A3
公开(公告)日：2012-09-20
申请号：PCT/US2012022671
申请日：2012-01-26
申请人： NOVOZYMES AS , NOVOZYMES INC , MORANT MARC D , HARRIS PAUL
发明人： MORANT MARC D , HARRIS PAUL
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C12N9/2445 , C12P7/14 , C12P19/02 , C12P19/14 , C12P21/00 , C12P2201/00 , C12Y302/01004 , C12Y302/01091 , Y02E50/16
摘要： The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有纤维二糖水解酶活性的分离的多肽和编码该多肽的分离的多核苷酸。本发明还涉及包含所述多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用所述多肽的方法。

4. 发明申请

WO2007109441A2 POLYPEPTIDES HAVING ENDOGLUCANASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有内切葡聚糖酶活性的多肽和编码相同的多核苷酸
公开(公告)号：WO2007109441A2
公开(公告)日：2007-09-27
申请号：PCT/US2007063710
申请日：2007-03-09
申请人： NOVOZYMES INC , NOVOZYMES AS , HARRIS PAUL , VLASENKO ELENA , LASSEN SOREN FLENSTED
发明人： HARRIS PAUL , VLASENKO ELENA , LASSEN SOREN FLENSTED
IPC分类号： C07K14/435
CPC分类号： C12N9/2434 , C12N9/2437 , C12Y302/01004
摘要： The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
摘要翻译：本发明涉及具有内切葡聚糖酶活性的分离的多肽和编码该多肽的分离的多核苷酸。本发明还涉及包含所述多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用所述多肽的方法。

5. 发明申请

WO2012044915A3 BETA-GLUCOSIDASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译： β-葡萄糖苷酶变体和编码它们的多核苷酸
公开(公告)号：WO2012044915A3
公开(公告)日：2012-06-14
申请号：PCT/US2011054185
申请日：2011-09-30
申请人： NOVOZYMES INC , WOGULIS MARK , HARRIS PAUL , OSBORN DAVID
发明人： WOGULIS MARK , HARRIS PAUL , OSBORN DAVID
IPC分类号： C12N9/42
CPC分类号： C12N9/2445 , C12P19/14 , C12Y302/01021 , Y02E50/16
摘要： The present invention relates to variants of a parent beta-glucosidase. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
摘要翻译：本发明涉及亲本β-葡糖苷酶的变体。本发明还涉及编码这些变体的多核苷酸; 核酸构建体，载体和包含多核苷酸的宿主细胞; 以及使用这些变体的方法。

6. 发明申请

WO2009111692A3 POLYPEPTIDES HAVING ENDOGLUCANASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
公开(公告)号：WO2009111692A3
公开(公告)日：2009-11-26
申请号：PCT/US2009036316
申请日：2009-03-06
申请人： NOVOZYMES AS , KROGH KRISTIAN , HARRIS PAUL
发明人： KROGH KRISTIAN , HARRIS PAUL
IPC分类号： C12N9/42 , C12N15/11 , C12N15/56 , C12P7/10
CPC分类号： C12N9/2437 , C12Y302/01004 , Y02E50/16
摘要： The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

7. 发明申请

WO2007115201A8 POLYPEPTIDES HAVING ENDOGLUCANASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有内切酶活性的多肽和编码其的多核苷酸
公开(公告)号：WO2007115201A8
公开(公告)日：2009-08-06
申请号：PCT/US2007065682
申请日：2007-03-30
申请人： NOVOZYMES INC , NOVOZYMES AS , HARRIS PAUL , VLASENKO ELENA , KAUPPINNEN MARCUS SAKARI , ZARETSKY ELIZABETH , TETER SARAH , BROWN KIMBERLY
发明人： HARRIS PAUL , VLASENKO ELENA , KAUPPINNEN MARCUS SAKARI , ZARETSKY ELIZABETH , TETER SARAH , BROWN KIMBERLY
IPC分类号： C12N9/42 , C07K14/37 , C12N15/56 , C12N15/82
CPC分类号： C12N9/244 , A61K38/00 , C07K14/5431 , C12N9/2437 , C12N15/1137 , C12P19/02 , C12P19/14 , C12P21/00 , C12Y302/01004 , Y02E50/16
摘要： The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
摘要翻译：本发明涉及具有内切葡聚糖酶活性的分离多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用多肽的方法。

8. 发明申请

WO2009085859A2 POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
公开(公告)号：WO2009085859A2
公开(公告)日：2009-07-09
申请号：PCT/US2008087231
申请日：2008-12-17
申请人： NOVOZYMES AS , HARRIS PAUL , MAIYURAN SUCHINDRA , BROWN KIMBERLY
发明人： HARRIS PAUL , MAIYURAN SUCHINDRA , BROWN KIMBERLY
IPC分类号： C07K14/39 , C12N9/42
CPC分类号： C07K14/37 , C12N9/2434
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

9. 发明申请

WO2012103300A8 POLYPEPTIDES HAVING CELLOBIOHYDROLASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有环糊精活性的多肽和编码其的多核苷酸
公开(公告)号：WO2012103300A8
公开(公告)日：2016-12-15
申请号：PCT/US2012022671
申请日：2012-01-26
申请人： NOVOZYMES AS , NOVOZYMES INC , MORANT MARC D , HARRIS PAUL
发明人： MORANT MARC D , HARRIS PAUL
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C12N9/2445 , C12P7/14 , C12P19/02 , C12P19/14 , C12P21/00 , C12P2201/00 , C12Y302/01004 , C12Y302/01091 , Y02E50/16
摘要： The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有纤维二糖水解酶活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

10. 发明申请

WO2011080267A3 GH61 POLYPEPTIDES HAVING DETERGENCY ENHANCING EFFECT 审中-公开
标题翻译： GH61多糖具有除臭效果
公开(公告)号：WO2011080267A3
公开(公告)日：2011-09-29
申请号：PCT/EP2010070795
申请日：2010-12-28
申请人： NOVOZYMES AS , ALLESEN-HOLM MARIE , ANDERSON LARS , SCHNORR KIRK MATTHEW , SPODSBERG NIKOLAJ , HARRIS PAUL
发明人： ALLESEN-HOLM MARIE , ANDERSON LARS , SCHNORR KIRK MATTHEW , SPODSBERG NIKOLAJ , HARRIS PAUL
IPC分类号： C11D3/386 , C07K14/37 , C12N9/24 , C12N9/30
CPC分类号： C12N9/242 , C11D3/3869
摘要： The present invention relates to the use of glycosyl hydrolase family 61 polypeptides as enhancers of enzyme benefits in detergents as well as a detergent composition comprising glycosyl hydrolase family 61 polypeptides in combination with detergency enzymes.
摘要翻译：本发明涉及糖基水解酶家族61多肽作为洗涤剂中酶有益效果的增强剂的用途，以及包含糖基水解酶家族61多肽与去污力酶的洗涤剂组合物的用途。

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