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1. 发明申请

WO2015120290A3 THIOL-X CLICK FOLDAMERS FOR POLYMER AFFINITY AND CATALYSIS LIBRARIES 审中-公开
标题翻译：用于聚合物亲和力和催化文库的THIOL-X点击折叠器
公开(公告)号：WO2015120290A3
公开(公告)日：2015-11-19
申请号：PCT/US2015014844
申请日：2015-02-06
申请人： UNIV COLORADO REGENTS
发明人： BOWMAN CHRISTOPHER N , KLOXIN CHRISTOPHER J , XI WEIXIAN , GONG TAO , PATTANAYAK SANKHA
IPC分类号： C12Q1/68 , C07D239/54
CPC分类号： C07D473/34 , C07D239/47 , C07D239/54 , C07D473/18 , C12N15/1048 , C12N15/1093 , C12Q1/6802 , C12Q1/6876
摘要： Click thiol-X monomers and polymers containing such monomers are disclosed. The clickable sequence controllable monomers include an optionally protected thiol moiety; an optionally protected Michael acceptor moiety; a primary functional side chain and one ore more secondary functional side chains. A clickable sequence controllable monomer, can have the structure: (formula), wherein independently Y and Z are atoms having a valence electrons of 3 or more; n is a integer from 0-10; m is a integer from 0-10; x is a integer from 0-10; PFS is a functional group SFSi; SFS2; and SFS3 are independently a combination of hydrogen, hydroxyl, aromatic, amine, carboxyl, and carbonyls, optionally substituted to form hydrophilic, hydrophobic, amphiphilic, or charged (positive or negative or both) side chains; T is an optionally protected thiol; and TCA is an optionally protected thiol-click acceptor. Methods of using such polymers are also disclosed.
摘要翻译：点击硫醇-X单体和含有这些单体的聚合物。可点击的序列可控单体包括任选保护的硫醇部分; 任选保护的迈克尔受体部分; 主要功能性侧链和一种或多种次要功能性侧链。可点击的序列可控单体可以具有以下结构：（式）其中独立地Y和Z是价电子数为3或更大的原子; n是0-10的整数; m是0-10的整数; x是0-10的整数; PFS是一个功能组SFSi; SFS2; 和SFS3独立地为氢，羟基，芳族，胺，羧基和羰基的组合，任选被取代以形成亲水性，疏水性，两亲性或带电荷（正或负或两者）侧链; T是任选保护的硫醇; 并且TCA是任选保护的巯基点击受体。也公开了使用这种聚合物的方法。

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