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1. 发明申请

WO2007131193A3 MAIN CHAIN ACID-DEGRADABLE POLYMERS FOR THE DELIVERY OF BIOACTIVE MATERIALS 审中-公开
标题翻译：用于输送生物材料的主链酸可降解聚合物
公开(公告)号：WO2007131193A3
公开(公告)日：2009-04-09
申请号：PCT/US2007068284
申请日：2007-05-04
申请人： UNIV CALIFORNIA , FRECHET JEAN M J , STANDLEY STEPHANY M , JAIN RACHNA , LEE CAMERON C
发明人： FRECHET JEAN M J , STANDLEY STEPHANY M , JAIN RACHNA , LEE CAMERON C
IPC分类号： A61K9/14
CPC分类号： A61K31/787 , A61K9/1641 , A61K47/34
摘要： Novel main chain acid degradable polymer backbones and drug delivery systems comprised of materials capable of delivering bioactive materials to cells for use as vaccines or other therapeutic agents are described. The polymers are synthesized using monomers that contain acid-degradable linkages cleavable under mild acidic conditions. The main chain of the resulting polymers readily degrade into many small molecules at low pH, but remain relatively stable and intact at physiological pH. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and other sites of inflammation.
摘要翻译：描述了由能够将生物活性物质递送至用作疫苗或其它治疗剂的细胞的材料组成的新型主链酸可降解聚合物主链和药物递送系统。使用含有酸可降解键的单体在温和的酸性条件下可裂解来合成聚合物。所得聚合物的主链在低pH下容易降解成许多小分子，但在生理pH下保持相对稳定和完整。新材料具有在细胞的内体或溶酶体区室内通常发现的条件下能够通过酸水解降解的共同特征，从而释放其在细胞内的有效载荷。这些材料也可以用于将治疗剂递送到肿瘤和其它炎症部位的酸性区域。

2. 发明申请

WO2009137267A2 SUPERHYDROPHOBIC AND SUPERHYDROPHILIC MATERIALS, SURFACES AND METHODS 审中-公开
标题翻译：超级和超级材料，表面和方法
公开(公告)号：WO2009137267A2
公开(公告)日：2009-11-12
申请号：PCT/US2009041277
申请日：2009-04-21
申请人： UNIV CALIFORNIA , SVEC FRANTISEK , LEVKIN PAVEL A , FRECHET JEAN M J
发明人： SVEC FRANTISEK , LEVKIN PAVEL A , FRECHET JEAN M J
IPC分类号： C08J9/224 , C08J5/00 , C08J9/22 , C08K7/00 , C08L25/08 , C08L33/06 , C08L33/14
CPC分类号： C08J9/286 , C08F220/18 , C08F222/1006 , C08J5/00 , C08J2333/16 , C08L33/16 , Y10T428/24355
摘要： A broadly applicable method requiring no more than a single step facilitates the preparation of large area super hydrophobic or super hydrophilic surfaces on a variety of substrates such as such as glass, metal, plastic, paper, wood, concrete and masonry. The technique involves the free radical polymerization of common acrylic or styrenic monomers in the presence of porogenic solvents in a mold or on a free surface. The material can be semi- or fully- transparent and either super hydrophobic or super hydrophilic depending on the choice of the monomers. Because porosity and dual scale roughness are intrinsic bulk properties of the monolithic materials and not only a surface characteristic, the polymers can be powdered to produce a super hydrophobic powder or otherwise fragmented and attached to the surface of any object to render it super hydrophobic or super hydrophilic. The surface properties of the porous material may also be altered locally by photografting with selected monomers.
摘要翻译：广泛应用的方法不需要单一步骤便于在各种基材如玻璃，金属，塑料，纸，木材，混凝土和砖石上制备大面积超疏水或超亲水表面。该技术涉及常规丙烯酸或苯乙烯类单体在造孔溶剂存在下在模具中或自由表面上的自由基聚合。根据单体的选择，该材料可以是半透明的或完全透明的，并且是超疏水的或超亲水的。由于孔隙率和双重尺度粗糙度是整体材料的固有本体特性，不仅表面特性，聚合物可以被粉末化以产生超疏水性粉末，或以其他方式分散和附着到任何物体的表面，使其超疏水或超级亲水性。多孔材料的表面性质也可以通过用选择的单体进行光刻而局部改变。

3. 发明申请

WO2005107047A3 FUNCTIONALIZED ELECTROACTIVE POLYMERS 审中-公开
标题翻译：功能化电极聚合物
公开(公告)号：WO2005107047A3
公开(公告)日：2006-09-08
申请号：PCT/US2005013873
申请日：2005-04-22
申请人： UNIV CALIFORNIA , FRECHET JEAN M J , LIU JINSONG , TANAKA TORU
发明人： FRECHET JEAN M J , LIU JINSONG , TANAKA TORU
IPC分类号： C08G75/00 , C08F283/00 , C08G61/12 , C08L81/00 , H01L51/00 , H02K23/60
CPC分类号： C08G61/126 , H01L51/0036 , H01L51/0043 , H01L51/0086 , H01L51/4226 , H01L2251/306 , Y02E10/549
摘要： Novel thiophene polymers include homopolymers and random or alternating polymers. They may be included in electronic conducting devices such as photovoltaic cells, transistors and light emitters. The polymers provide improved performance in thin film transistors and electronic devices in which they are incorporated.
摘要翻译：新型噻吩聚合物包括均聚物和无规或交替聚合物。它们可以被包括在诸如光伏电池，晶体管和发光体的电子导电装置中。这些聚合物在其中并入其中的薄膜晶体管和电子器件中提供了改进的性能。

4. 发明申请

WO2005017487A2 MATRIX FOR MALDI ANALYSIS BASED ON POROUS POLYMER MONOLITHS 审中-公开
标题翻译：基于多孔聚合物单体的MALDI分析矩阵
公开(公告)号：WO2005017487A2
公开(公告)日：2005-02-24
申请号：PCT/US2004018499
申请日：2004-06-09
申请人： UNIV CALIFORNIA
发明人： FRECHET JEAN M J , SVEC FRANTISEK , PETERSON DOMINIC S , LUO QUANZHOU
IPC分类号： G01N20060101 , H01J49/00 , H01J49/16 , G01N
CPC分类号： H01J49/0418
摘要： The use of porous polymer monolithic matrix for matrix-assisted laser desorption/ionization time of flight mass spectrometry analysis on a sample suspected of containing an analyte is herein described. The porous polymer monoliths provide a matrix suitable for use in detecting and analyzing low molecular weight and small molecules. The matrices described herein also facilitate the creation of arrays of monolithic matrices for high-throughput detection and screening using MALDI-TOF mass spectrometry and exhibit a long shelf-life.
摘要翻译：本文描述了在疑似含有分析物的样品上使用多孔聚合物整体式基质用于基质辅助激光解吸/电离飞行时间质谱分析。多孔聚合物整料提供适用于检测和分析低分子量和小分子的基质。本文所述的基质还有助于创建用于高通量检测和筛选的单片矩阵阵列，其使用MALDI-TOF质谱法并展现出长的保存期限。

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