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1. 发明申请

WO2008147530A1 INTEGRATED FLUIDIC DEVICES WITH MAGNETIC SORTING 审中-公开
标题翻译：具有磁性分离的集成流体装置
公开(公告)号：WO2008147530A1
公开(公告)日：2008-12-04
申请号：PCT/US2008006599
申请日：2008-05-23
申请人： UNIV CALIFORNIA , CYTOMX LLC , SOH HYONGSOK , FERGUSON BRIAN SCOTT , ZHANG YANTING , STAGLIANO NANCY E
发明人： SOH HYONGSOK , FERGUSON BRIAN SCOTT , ZHANG YANTING , STAGLIANO NANCY E
IPC分类号： B03C1/00
CPC分类号： B03C1/015 , B01L3/502761 , B01L2200/0636 , B01L2200/0668 , B03C1/286 , B03C1/288 , B03C5/028 , B03C2201/18 , B03C2201/26
摘要： A fluidic device employs one or more sorting stations for separating target species from other species in a sample. At least one of the sorting stations employs a magnetic field gradient to accomplish separation. In addition, the sorting station is integrated on a single substrate with one or more other modules for processing the sample. For example, the fluidic device may include both a sorting station and a separate trapping station that holds some or all components of the sample for additional processing. The trapping station may be located at a position upstream or downstream from the sorting module.
摘要翻译：流体装置采用一个或多个分选站，用于将样品中的目标物种与其他物种分离。至少一个分选站采用磁场梯度来实现分离。此外，分选站集成在具有用于处理样品的一个或多个其他模块的单个基板上。例如，流体装置可以包括分选站和分离收集站，分离站收集样品的一些或所有组分以用于附加处理。捕集站可以位于分拣模块上游或下游的位置。

2. 发明申请

WO2008048616A3 MICROFLUIDIC MAGNETOPHORETIC DEVICE AND METHODS FOR USING THE SAME 审中-公开
标题翻译：微流控磁体装置及其使用方法
公开(公告)号：WO2008048616A3
公开(公告)日：2008-06-12
申请号：PCT/US2007022105
申请日：2007-10-16
申请人： UNIV CALIFORNIA , OH SANG-HYUN , SINGH AMARENDRA KUMAR , ZHANG YANTING , NAWARATHNA DHARMAKIRTHI , KIM UNYOUNG , DAUGHERTY PATRICK SEAN , SOH HYONGSOK , FERGUSON BRIAN SCOTT
发明人： OH SANG-HYUN , SINGH AMARENDRA KUMAR , ZHANG YANTING , NAWARATHNA DHARMAKEERTHI , KIM UNYOUNG , DAUGHERTY PATRICK SEAN , SOH HYONGSOK , FERGUSON BRIAN SCOTT
IPC分类号： B01L3/00 , B03C1/02 , G01N33/543 , G01N35/00
CPC分类号： B01L3/502776 , B01L3/502761 , B01L2200/0636 , B01L2200/0647 , B01L2200/0668 , B01L2300/0864 , B01L2400/043 , B03C1/32 , B03C2201/18
摘要： A microfluidic device may employ one or more sorting stations for separating target species from other species in a sample. The separation is driven by magnetophoresis. A sorting station generally includes separate buffer and sample streams. A magnetic field gradient applied to the sorting station deflects the flow path of magnetic particles (which selectively label the target species) from a sample stream into a buffer stream. The buffer stream leaving the sorting station is used to detect or further process purified target species labeled with the magnetic particles.
摘要翻译：微流体装置可以采用一个或多个分选站，用于将样品中的目标物种与其他物种分离。分离由磁电泳驱动。分选站通常包括单独的缓冲器和采样流。施加到分选站的磁场梯度将磁性粒子（其选择性地标记目标物种）的流动路径偏转成缓冲液流。离开分选站的缓冲液流用于检测或进一步处理用磁性颗粒标记的纯化目标物种。

3. 发明申请

WO2009073063A2 HIGH-STRINGENCY SCREENING OF TARGET-BINDING PARTNERS USING A MICROFLUDIC DEVICE 审中-公开
标题翻译：使用微型流感设备对目标绑定伙伴进行高度紧密的筛选
公开(公告)号：WO2009073063A2
公开(公告)日：2009-06-11
申请号：PCT/US2008011452
申请日：2008-10-03
申请人： UNIV CALIFORNIA , SOH HYONGSOK , LOU XINHUI , LAGALLY ERIC
发明人： SOH HYONGSOK , LOU XINHUI , LAGALLY ERIC
IPC分类号： C40B30/04
CPC分类号： C40B30/04 , B01J2219/005 , B01J2219/00563 , B01J2219/00722 , B01J2219/00725 , B01J2219/085 , B01L3/502761 , B01L2200/0652 , B01L2400/043 , B01L2400/0454 , C12N15/1013 , C12N15/1034 , C40B70/00
摘要： The invention provides a method of screening a library of candidate agents by contacting the library with a target in a reaction mixture under a condition of high stringency, wherein the target includes a tag that responds to a controllable force applied to the tag, and passing the members of the library through a microfluidic device in a manner that exposes the library members to the controllable force, thereby displacing members of the library that are bound to the target relative to their unbound counterparts. Kits and systems for use with the methods of the invention are also provided.
摘要翻译：本发明提供了一种筛选候选药物文库的方法，该方法是在高度严格的条件下使文库与反应混合物中的靶标接触，其中靶标包括响应于施加于标签的可控力的标签，图书馆的成员通过微流体装置以使图书馆成员暴露于可控力的方式，从而使与目标相关的图书馆成员相对于他们的未绑定对象流离失所。还提供了与本发明的方法一起使用的试剂盒和系统。

4. 发明申请

WO2009132151A2 MICROFLUIDIC DEVICES AND METHODS OF USING SAME 审中-公开
标题翻译：微流体装置及其使用方法
公开(公告)号：WO2009132151A2
公开(公告)日：2009-10-29
申请号：PCT/US2009041466
申请日：2009-04-22
申请人： UNIV CALIFORNIA , SOH HYONGSOK , ADAMS JONATHAN D , KIM UNYOUNG
发明人： SOH HYONGSOK , ADAMS JONATHAN D , KIM UNYOUNG
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L3/502776 , B01L2400/043 , G01N33/54326
摘要： The present disclosure provides microfluidic devices and methods which facilitate high performance separation and/or purification of one or more target species from complex samples with high purity, recovery and throughput. The disclosed microfluidic devices and methods utilize one or more controllable forces to effect the separation and/or purification of the one or more target species.
摘要翻译：本公开提供了微流体装置和方法，其促进高纯度，回收率和产量的复杂样品中高效分离和/或纯化一种或多种靶物质。所公开的微流体装置和方法利用一个或多个可控力来实现一种或多种目标物种的分离和/或纯化。

5. 发明申请

WO2008127292A3 SCREENING MOLECULAR LIBRARIES USING MICROFLUIDIC DEVICES 审中-公开
标题翻译：使用微流体装置筛选分子图谱
公开(公告)号：WO2008127292A3
公开(公告)日：2008-12-18
申请号：PCT/US2007022118
申请日：2007-10-16
申请人： UNIV CALIFORNIA , SOH HYONGSOK , DAUGHERTY PATRICK SEAN , OH SANG-HYUN
发明人： SOH HYONGSOK , DAUGHERTY PATRICK SEAN , OH SANG-HYUN
IPC分类号： C40B60/04 , G01N33/553
CPC分类号： B03C1/286 , B01J2219/005 , B01J2219/00563 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00648 , B01J2219/00655 , B01J2219/00707 , B01L3/502761 , B01L3/502776 , B01L2200/0652 , B01L2300/0864 , B01L2400/043 , B01L2400/0487 , B03C1/30 , B03C2201/18
摘要： Screening in a microfluidic device is mediated by a magnetic field that in some manner displaces or otherwise activates the entities of interest. Entities of interest can be identified and/or separated from one or more other components provided to the microfluidic device. Microfluidic devices may have mechanisms that apply a defined magnetic field to a region of the microfluidic device where library members pass through sequentially and/or in parallel.
摘要翻译：在微流体装置中的筛选由磁场介导，磁场以某种方式置换或以其他方式激活感兴趣的实体。感兴趣的实体可以被识别和/或从提供给微流体装置的一个或多个其它组件分离。微流体装置可以具有将定义的磁场施加到微流体装置的区域的机制，其中库构件顺序地和/或并行穿过。

6. 发明申请

WO2014088830A3 SCREENING OF NUCLEIC ACID AGENTS VIA PARTICLE DISPLAY 审中-公开
标题翻译：通过颗粒显示筛选核酸试剂
公开(公告)号：WO2014088830A3
公开(公告)日：2015-07-16
申请号：PCT/US2013071318
申请日：2013-11-21
申请人： UNIV CALIFORNIA
发明人： WANG JINPENG , SOH HYONGSOK , GONG QIANG
IPC分类号： C40B30/04
CPC分类号： C12N15/1048 , C12N15/1037 , C12N15/115 , C12N2310/16 , C12N2310/351 , C12N2320/11 , C12N2320/13 , C12Q2541/101
摘要： The present disclosure provides a method for identifying one or more nucleic acid agents, e.g., aptamers, having a desired property from a mixture of candidate nucleic acid agents. The method generally includes immobilizing the mixture of candidate nucleic acid agents onto particles, wherein only a subset of the candidate nucleic acid agents are immobilized on any one of the particles, and wherein the subset is present in multiple copies. The particles are exposed to a target, and particles including candidate nucleic acid agents having the desired property are isolated. In this way, one or more nucleic acid agents having the desired property may be identified. Related compositions and nucleic acid agents identified as having one or more desired properties are also provided.
摘要翻译：本公开提供了用于从候选核酸试剂的混合物鉴定具有所需性质的一种或多种核酸试剂（例如适体）的方法。该方法通常包括将候选核酸试剂的混合物固定在颗粒上，其中只有候选核酸试剂的一个子集被固定在任何一个颗粒上，并且其中该子集以多个拷贝存在。将颗粒暴露于靶，并且分离包含具有所需性质的候选核酸试剂的颗粒。以这种方式，可以鉴定具有所需性质的一种或多种核酸试剂。还提供了鉴定为具有一种或多种所需性质的相关组合物和核酸试剂。

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