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1. 发明申请

WO2009053725A3 PEPTIDES AND USES THEREOF 审中-公开
标题翻译：肽及其用途
公开(公告)号：WO2009053725A3
公开(公告)日：2009-07-30
申请号：PCT/GB2008003637
申请日：2008-10-27
申请人： UNIV BELFAST , KING S COLLEGE LONDON , SHAW CHRISTOPHER , JONES PETER , PERSAUD SHANTA , CHEN TIANBAO , WALKER BRIAN
发明人： SHAW CHRISTOPHER , JONES PETER , PERSAUD SHANTA , CHEN TIANBAO , WALKER BRIAN
IPC分类号： C07K14/575 , A61K38/22 , A61P3/00
CPC分类号： A61K31/7004 , A61K38/00 , C07K14/575 , A61K2300/00
摘要： The invention relates to fragments of Chromogranin A (CgA) derived peptide fragments and their use in methods of therapy, for example in the treatment of diabetes etc. The peptides, for example AL-11, GV-19 and WE-14, are tropic, i.e stimulate release of regulatory substances and may be used in the absence of a stimulatory concentration of glucose.
摘要翻译：本发明涉及嗜铬粒蛋白A（CgA）衍生的肽片段的片段及其在治疗方法中的用途，例如用于治疗糖尿病等。所述肽，例如AL-11，GV-19和WE-14是热带即刺激调节物质的释放，并且可以在没有刺激浓度的葡萄糖的情况下使用。

2. 发明申请

WO2008107722A3 PEPTIDES, COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：肽，组合物及其用途
公开(公告)号：WO2008107722A3
公开(公告)日：2009-01-15
申请号：PCT/GB2008050163
申请日：2008-03-07
申请人： UNIV BELFAST , SHAW CHRISTOPHER , CHEN TIANBAO , O'ROURKE MARTIN , WALKER BRIAN , HIRST DAVID
发明人： SHAW CHRISTOPHER , CHEN TIANBAO , O'ROURKE MARTIN , WALKER BRIAN , HIRST DAVID
IPC分类号： C07K7/18 , C07K7/00
CPC分类号： C07K7/18 , C07K14/47
摘要： Described is an N-terminal hexapeptide fragment of maximakinin, QUB 698.8, which exhibits potent tissue selective actions on smooth muscle. It demonstrates a high degree of selectivity for arterial smooth muscle over small intestinal smooth muscle, causing potent relaxation of arterial smooth muscle, while causing less potent contraction of ileal smooth muscle. It may be used treatment of diseases of the cardiovascular system and in promotion of angiogenesis.
摘要翻译：描述的是最大蛋白质的N末端六肽片段，QUB 698.8，其在平滑肌上表现出有力的组织选择性作用。它表现出对小肠平滑肌的动脉平滑肌的高度选择性，导致动脉平滑肌的强力松弛，同时引起回肠平滑肌的较不有效的收缩。它可用于治疗心血管系统疾病和促进血管生成。

3. 发明申请

WO2004074312A3 TRYPTOPHYLLIN PEPTIDES AND USES THEREOF 审中-公开
标题翻译：三苯乙烯肽及其用途
公开(公告)号：WO2004074312A3
公开(公告)日：2005-01-06
申请号：PCT/IB2004000806
申请日：2004-02-04
申请人： UNIV ULSTER , SHAW CHRIS , HIRST DAVID , CHEN TIANBAO , O'ROURKE MARTIN
发明人： SHAW CHRIS , HIRST DAVID , CHEN TIANBAO , O'ROURKE MARTIN
IPC分类号： A61K38/00 , A61K38/04 , A61P9/08 , C07K20060101 , C07K7/06 , C07K14/46
CPC分类号： C07K7/06 , A61K38/00 , C07K14/463
摘要： A vasodilatory tryptophyllin peptide, PdT-1, isolated from frog (Pachymedusa dacnicolor) defensive skin secretion, fragments and analogs thereof, are disclosed. The structure of PdT-1 is Lys-Pro-Hyp-Ala-Trp-Val-Pro.NH2 (SEQ ID NO: 1). Also disclosed are tryptophyllin analogs, prodrugs including the peptides, fusion peptides and multimeric peptides including the peptide sequences, pharmaceutical compositions including PdT-1 and analogs thereof, nucleic acids encoding PdT-1 and analogs thereof, and methods of treatment of diseases for which vasodilation is beneficial using such peptides and nucleic acids.
摘要翻译：公开了从青蛙（Pachymedusa dacnicolor）防御性皮肤分泌中分离的血管扩张性色氨酰蛋白肽PdT-1，其片段和类似物。 PdT-1的结构是Lys-Pro-Hyp-Ala-Trp-Val-Pro.NH 2（SEQ ID NO：1）。还公开了色氨酰蛋白类似物，包括肽的前药，包括肽序列的融合肽和多聚体肽，包括PdT-1及其类似物的药物组合物，编码PdT-1的核酸及其类似物，以及治疗血管扩张疾病的方法使用这样的肽和核酸是有益的。

4. 发明申请

WO2004068928A3 BRADYKININ B2 RECEPTOR ANTAGONIST PEPTIDE FROM AMPHIBIAN SKIN 审中-公开
标题翻译：来自AMPHIBIAN皮肤的BRADYKININ B2受体拮抗肽
公开(公告)号：WO2004068928A3
公开(公告)日：2005-08-11
申请号：PCT/GB2004000473
申请日：2004-02-06
申请人： UUTECH LTD , SHAW CHRIS , HIRST DAVID , CHEN TIANBAO , O'ROURKE MARTIN , RAO PINGFAN
发明人： SHAW CHRIS , HIRST DAVID , CHEN TIANBAO , O'ROURKE MARTIN , RAO PINGFAN
IPC分类号： C07K7/18 , C12N15/12 , A61K38/10 , A61P21/00
CPC分类号： C07K7/18
摘要： A bradykinin B2-receptor antagonist peptide, kinestatin, isolated from toad (Bombina maxima) defensive skin secretion, and analogs thereof, is disclosed. The structure of kinestatin is pGlu-Leu/Ile-Pro-Gly-Leu/Ile-Gly-Pro-Leu/Ile-Arg-NH2. Also disclosed are kinestatin analogs, prodrugs including the peptides, fusion peptides and multimeric peptides including the peptide sequences, pharmaceutical compositions including kinestatin and analogs thereof, prodrugs, fusion and multimeric peptides thereof, nucleic acids encoding kinestatin and analogs thereof, and nucleic acids encoding the fusion and multimeric peptides. Kinestatin and analogs thereof (including the prodrugs and multimeric and/or fusion peptides) can be used to treat and/or prevent disorders associated with bradykinin, including cardiovascular disorders, inflammation, asthma, allergic rhinitis, pain, angiogenesis and the like.
摘要翻译：公开了从蟾蜍（Bombina maxima）防御性皮肤分泌物中分离出的缓激肽B2受体拮抗剂肽kinestatin及其类似物。 kinestatin的结构是pGlu-Leu / Ile-Pro-Gly-Leu / Ile-Gly-Pro-Leu / Ile-Arg-NH2。还公开了活性抑素类似物，前药，包括肽，融合肽和多聚体肽，包括肽序列，药物组合物，包括激活素及其类似物，前药，其融合和多聚肽，编码激酶和其类似物的核酸，以及编码融合和多聚体肽。抗癌药及其类似物（包括前体药物和多聚体和/或融合肽）可用于治疗和/或预防与缓激肽相关的疾病，包括心血管疾病，炎症，哮喘，过敏性鼻炎，疼痛，血管发生等。

5. 发明申请

WO2004069857A3 "PEPTIDES, COMPOSITIONS AND USES THEREOF" 审中-公开
标题翻译： “肽，组合物及其用途”
公开(公告)号：WO2004069857A3
公开(公告)日：2004-11-18
申请号：PCT/GB2004000470
申请日：2004-02-06
申请人： UUTECH LTD , SHAW CHRIS , HIRST DAVID , CHEN TIANBAO , O'ROURKE MARTIN , RAO PINGFAN
发明人： SHAW CHRIS , HIRST DAVID , CHEN TIANBAO , O'ROURKE MARTIN , RAO PINGFAN
IPC分类号： A61K38/00 , C07K7/18 , C07K14/81 , A61K38/17
CPC分类号： C07K7/18 , A61K38/00
摘要： A bradykinin agonist peptide, maximakinin, isolated from toad (Bombina maxima) defensive skin secretion, fragments and analogs thereof, are disclosed. The structure of maximakinin is DLPKINRKGPRPPGFSPFR. Also disclosed are maximakinin analogs, prodrugs including the peptides, fusion peptides and multimeric peptides including the peptide sequences, pharmaceutical compositions including maximakinin and analogs thereof, prodrugs, fusion and multimeric peptides thereof, nucleic acids encoding maximakinin and analogs thereof, and nucleic acids encoding the fusion and multimeric peptides.
摘要翻译：公开了从蟾蜍（Bombina maxima）防御性皮肤分泌物中分离的缓激肽激动剂肽，maximakinin，其片段和类似物。 maximakinin的结构是DLPKINRKGPRPPGFSPFR。还公开了maximakinin类似物，包括肽的前药，包括肽序列的融合肽和多聚体肽，包括maximakinin及其类似物的药物组合物，前药，其融合和多聚体肽，编码maximakinin及其类似物的核酸，以及编码融合和多聚体肽。

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