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1. 发明申请

WO2008086813A3 PEPTIDES DERIVED FROM PROTEINS OF THE INSULIN SUPER-FAMILY 审中-公开
标题翻译：从胰岛素超家族蛋白衍生的肽
公开(公告)号：WO2008086813A3
公开(公告)日：2008-12-04
申请号：PCT/DK2008050009
申请日：2008-01-18
申请人： UINV KOBENHAVNS , BOCK ELISABETH , BEREZIN VLADIMIR
发明人： BOCK ELISABETH , BEREZIN VLADIMIR
IPC分类号： C07K14/65 , A61K38/30 , A61K39/395 , C07K7/04 , C12N15/09
CPC分类号： C07K14/62 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/65
摘要： The present invention relates to peptides derived from members of the insulin super-family. The peptides preferably bind and modify the activation status of receptors of proteins of the insulin super-family. The invention also relates to a pharmaceutical composition containing a compound comprising one or more of the peptides capable of promoting cell differentiation and/or modulating neuronal plasticity and/or proliferation of neural cells, and/or modulating survival and/or regeneration of cells expressing a receptor of a protein of the insulin super-family. The peptides may further be used to treat conditions affecting the peripheral and/or the central nervous system and/or muscles and other tissues or for treatment of normal, degenerated or damaged cells which express receptors of one or more proteins of the insulin super-family.
摘要翻译：本发明涉及衍生自胰岛素超家族成员的肽。肽优选结合并修饰胰岛素超家族的蛋白质的受体的活化状态。本发明还涉及包含一种或多种能够促进神经细胞的神经元可塑性和/或神经细胞增殖的调节和/或调节神经细胞的可塑性和/或增殖的一种或多种肽的化合物的药物组合物，和/或调节表达细胞的细胞的存活和/或再生胰岛素超家族蛋白的受体。肽可以进一步用于治疗影响外周和/或中枢神经系统和/或肌肉和其他组织的病症，或用于治疗表达胰岛素超家族的一种或多种蛋白质的受体的正常，退化或损伤的细胞。

2. 发明申请

WO2009068042A3 NOVEL PEPTIDES DERIVED FROM NCAM (FGLS) 审中-公开
标题翻译： NCAM衍生的新肽（FGLS）
公开(公告)号：WO2009068042A3
公开(公告)日：2009-07-30
申请号：PCT/DK2008050282
申请日：2008-11-28
申请人： ENKAM PHARMACEUTICALS AS , COPENHAGEN UNIVERSITY , BEREZIN VLADIMIR , BOCK ELISABETH , EBDRUP SOEREN , KLEMENTIEV BORIS
发明人： BEREZIN VLADIMIR , BOCK ELISABETH , EBDRUP SOEREN , KLEMENTIEV BORIS
IPC分类号： C07K14/705 , A61P25/00 , C07K19/00
CPC分类号： C07K14/70503 , A61K38/00
摘要： The present invention relates to novel compounds comprising at most 13 contiguous amino acid residues derived from the fibronectin type 3,Il module of neural cell adhesion molecule (NCAM), or a variant or fragment thereof, capable of interacting with an FGFR and thereby the compounds are capable of inducing differentiation, modulating proliferation, stimulate regeneration, neuronal plasticity and/or survival of cells. Further, the present invention relates to the use of said compounds for production of a medicament for treatment of conditions and diseases, wherein NCAM and/or FGFR play a prominent role.
摘要翻译：本发明涉及新型化合物，其包含至少13个来源于3型纤连蛋白的连续氨基酸残基，神经细胞粘附分子（NCAM）的II模块或其变体或片段，其能够与FGFR相互作用，从而化合物能够诱导分化，调节增殖，刺激再生，细胞的神经元可塑性和/或存活。此外，本发明涉及所述化合物在制备用于治疗病症和疾病的药物中的用途，其中NCAM和/或FGFR发挥显着作用。

3. 发明申请

WO2007071248A8 NEURITOGENIC AND NEURONAL SURVIVAL PROMOTING PEPTIDES DERIVED FROM THE FAMILY OF S-100 PROTEINS 审中-公开
标题翻译：从S-100蛋白家族衍生的神经生长因子和神经营养促进肽
公开(公告)号：WO2007071248A8
公开(公告)日：2007-09-13
申请号：PCT/DK2006000730
申请日：2006-12-20
申请人： COPENHAGEN UNIVERSITY , BOCK ELISABETH , BEREZIN VLADIMIR , KIRYUSHKO DARYA
发明人： BOCK ELISABETH , BEREZIN VLADIMIR , KIRYUSHKO DARYA
IPC分类号： C07K14/43 , A61K38/17 , C07K14/47
CPC分类号： C07K14/4728 , A61K38/00
摘要： The present invention relates to peptide fragments derived from proteins of the S-100 family promoting neural cell survival, differentiation and proliferation. The invention further relates to pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of diseases and conditions where the effects of stimulating neural cell proliferation, differentiation and/or survival, and/or stimulating neural plasticity associated with learning and memory are beneficial for treatment.
摘要翻译：本发明涉及衍生自S-100家族蛋白质的肽片段，促进神经细胞存活，分化和增殖。本发明还涉及包含所述肽片段的药物组合物及其用于治疗刺激神经细胞增殖，分化和/或存活和/或刺激与学习和记忆相关的神经可塑性的效果有益于治疗的疾病和病症的用途。

4. 发明申请

WO2007045247A3 FIBROBLAST GROWTH FACTOR RECEPTOR-DERIVED PEPTIDES 审中-公开
标题翻译：成纤维细胞生长因子受体衍生肽
公开(公告)号：WO2007045247A3
公开(公告)日：2007-06-14
申请号：PCT/DK2006000585
申请日：2006-10-17
申请人： ENKAM PHARMACEUTICALS AS , BEREZIN VLADIMIR , KISELYOV VLADISLAV V , BOCK ELISABETH
发明人： BEREZIN VLADIMIR , KISELYOV VLADISLAV V , BOCK ELISABETH
IPC分类号： C07K14/71 , C07K14/47
CPC分类号： C07K14/71 , A61K38/00
摘要： The present invention relates to novel peptides capable of binding to a receptor of the fibroblast growth factor receptor family (FGFRs) and modulating activity of said receptor. The peptides of the invention are fragments of FGFRs, wherein said fragments comprise amino acid residues involved in the reciprocal interaction of the Immunoglobulin-like modules 2 (Ig2) and Immunoglobulin-like module 1 (Ig1) of FGFR. The invention discloses amino acid sequences derived from the reciprocal Ig 1 -to-lg2 binding site of FGFR and relates to use of the peptides comprising said amino acid sequences for the treatment of different pathological conditions, wherein FGFRs play a prominent role. Accordingly, pharmaceutical compositions comprising the compounds of the invention are also concerned.
摘要翻译：本发明涉及能够结合成纤维细胞生长因子受体家族（FGFR）受体并调节所述受体活性的新型肽。本发明的肽是FGFR的片段，其中所述片段包含涉及FGFR的免疫球蛋白样组件2（Ig2）和免疫球蛋白样组件1（Ig1）的相互作用的氨基酸残基。本发明公开了衍生自FGFR的互补Ig 1至Ig 1结合位点的氨基酸序列，并且涉及包含所述氨基酸序列的肽用于治疗不同病理学病症的用途，其中FGFR发挥显着作用。因此，包含本发明化合物的药物组合物也受到关注。

5. 发明申请

WO0247719A2 SURVICAL PROMOTING NCAM BINDING AND NCAM LIGAND BIDING COMPOUNDS 审中-公开
标题翻译：支持NCAM绑定和NCAM配对绑定化合物
公开(公告)号：WO0247719A2
公开(公告)日：2002-06-20
申请号：PCT/DK0100822
申请日：2001-12-12
申请人： ENKAM PHARMACEUTICALS AS , BOCK ELISABETH , BEREZIN VLADIMIR , KOEHLER LENE BORDING
发明人： BOCK ELISABETH , BEREZIN VLADIMIR , KOEHLER LENE BORDING
IPC分类号： A61K38/00 , A61K39/395 , A61P3/10 , A61P9/10 , A61P13/12 , A61P15/00 , A61P21/02 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/28 , C07K14/47 , C07K14/705
CPC分类号： C07K14/70503 , A61K38/00 , A61K2039/505
摘要： The present invention relates to compounds capable of stimulating survival of cells presenting the neural cell adhesion molecule (NCAM) or an NCAM-ligand (counter-receptor), such as neurons. Further, the present invention relates to the use of pharmaceutical compositions and medicaments in the treatment or protection of cells presenting NCAM or NCAM ligands. More particularly the invention describes the use of a compound comprising a peptide comprising at least 5 contiguous amino acid residues from an amino acid sequence of NCAM, a fragment thereof, or a variant thereof or a mimic thereof, for the preparation of a medicament for preventing cell death of cells presenting said NCAM or an NCAM ligand.
摘要翻译：本发明涉及能够刺激呈现神经细胞粘附分子（NCAM）的细胞或NCAM-配体（反受体）如神经元的存活的化合物。此外，本发明涉及药物组合物和药物在治疗或保护呈现NCAM或NCAM配体的细胞中的用途。更具体地，本发明描述了包含由NCAM的氨基酸序列至少5个连续氨基酸残基的肽的化合物，其片段或其变体或其模拟物在制备用于预防呈现所述NCAM或NCAM配体的细胞的细胞死亡。

6. 发明申请

WO2010136031A1 FIBROBLAST GROWTH FACTOR RECEPTOR-DERIVED PEPTIDES BINDING TO NCAM 审中-公开
标题翻译：纤维母细胞生长因子受体衍生肽与NCAM结合
公开(公告)号：WO2010136031A1
公开(公告)日：2010-12-02
申请号：PCT/DK2009050119
申请日：2009-05-27
申请人： UNIV KOEBENHAVN , BEREZIN VLADIMIR , BOCK ELISABETH , KOCHOYAN ARTHUR
发明人： BEREZIN VLADIMIR , BOCK ELISABETH , KOCHOYAN ARTHUR
IPC分类号： C07K14/71
CPC分类号： C07K16/42 , A61K38/179 , C07K2317/70
摘要： The present invention relates to the use of peptides that are capable of binding to, and modulating the activity of NCAM. The peptides are peptide fragments of FGFRs. They are derived from two distinct binding sites for binding of the immunoglobulin-like module 2 of FGFR to NCAM F3 modules 1-2. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein NCAM and/or FGFRs play a prominent role.
摘要翻译：本发明涉及能够结合并调节NCAM活性的肽的用途。肽是FGFR的肽片段。它们衍生自用于结合FGFR的免疫球蛋白样模块2与NCAM F3模块1-2的两个不同的结合位点。本发明还涉及所述肽在生产用于治疗不同病理状况的药物中的用途，其中NCAM和/或FGFRs起着重要作用。

7. 发明申请

WO2008151637A2 NEUROPLASTIN DERIVED PEPTIDES 审中-公开
标题翻译：神经母细胞衍生肽
公开(公告)号：WO2008151637A2
公开(公告)日：2008-12-18
申请号：PCT/DK2008050139
申请日：2008-06-12
申请人： COPENHAGEN UNIVERSITY , BEREZIN VLADIMIR , BOCK ELISABETH , SOROKA VLADISLAV
发明人： BEREZIN VLADIMIR , BOCK ELISABETH , SOROKA VLADISLAV
IPC分类号： A61K38/17 , A61K38/08 , A61K38/10 , A61K39/395 , A61P9/10 , A61P25/28 , A61P35/00
CPC分类号： A61K38/17
摘要： The present invention relates to peptides derived from neuroplastin which are capable of inducing neurite outgrowth by modulating intracellular calcium concentration and activity of intracellular signalling molecules such as Akt, Erk1/2 and CREB through binding and/or modulation of receptor tyrosine kinases including but not limited to Fibroblast Growth Factor receptors (FGFRs). The peptides are derived from neuroplastin or fragments thereof. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein neuroplastin and/or receptor tyrosine kinases, including but not limited to FGFRs, play a prominent role.
摘要翻译：本发明涉及衍生自神经淀粉蛋白的肽，其能够通过结合和/或调节受体酪氨酸激酶（包括但不限于）调节细胞内钙浓度和细胞内信号分子如Akt，Erk1 / 2和CREB的活性而诱导神经突生长成纤维细胞生长因子受体（FGFR）。肽衍生自神经淀粉蛋白或其片段。本发明还涉及所述肽用于生产用于治疗不同病理状况的药物的用途，其中包括但不限于FGFR的神经淀粉蛋白和/或受体酪氨酸激酶起着突出的作用。

8. 发明申请

WO2005123759A3 FGFR binding peptides 审中-公开
标题翻译： FGFR结合肽
公开(公告)号：WO2005123759A3
公开(公告)日：2006-05-04
申请号：PCT/DK2005000400
申请日：2005-06-17
申请人： ENKAM PHARMACEUTICALS AS , BOCK ELISABETH , BEREZIN VLADIMIR
发明人： BOCH ELISABETH , BEREZIN VLADIMIR
IPC分类号： C07K7/00 , C07K14/705 , A61K38/17 , A61P25/28 , C07K16/28
CPC分类号： C07K14/70503
摘要： The present invention relates to new peptide compounds capable of direct binding to fibroblast growth factor receptor (FGFR) and activating said receptor. The compounds of the invention comprise peptide fragments of the neural cell adhesion molecule (NCAM) derived from the fibronectin type-III module 1 (F3, 1) of NCAM. Peptide sequences of the invention are capable of stimulating learning and memory and/or neurite outgrowth and/or neural cell survival. Peptide sequences and compounds comprising thereof, according to the invention, may be beneficially used for treatment and/or prevention of different pathological conditions wherein FGFR and/or NCAM play a role in pathology and/or recovery from disease. Accordingly, pharmaceutical compositions comprising the peptide sequences and compounds of the invention are also in the scope of protection.
摘要翻译：本发明涉及能够直接结合成纤维细胞生长因子受体（FGFR）并激活所述受体的新肽化合物。本发明的化合物包含衍生自NCAM的纤连蛋白III型模块1（F3，1）的神经细胞粘附分子（NCAM）的肽片段。本发明的肽序列能够刺激学习和记忆和/或神经突生长和/或神经细胞存活。根据本发明的包含其的肽序列及其化合物可有利地用于治疗和/或预防其中FGFR和/或NCAM在病理学和/或疾病恢复中起作用的不同病理状况。因此，包含本发明的肽序列和化合物的药物组合物也在保护范围内。

9. 发明申请

WO2005121168A3 HEPARIN BINDING PEPTIDE 审中-公开
公开(公告)号：WO2005121168A3
公开(公告)日：2006-03-16
申请号：PCT/DK2005000382
申请日：2005-06-10
申请人： ENKAM PHARMACEUTICALS AS , BOCK ELISABETH , BEREZIN VLADIMIR
发明人： BOCK ELISABETH , BEREZIN VLADIMIR
IPC分类号： C07K14/705 , A61K38/17 , A61K39/395 , A61P25/28 , C07K7/00 , C07K16/28
CPC分类号： C07K14/70503
摘要： The invention relates to new peptide fragments capable of stimulating neurite outgrowth, stimulating of cell survival, stimulating neural plasticity associated with memory and learning, and modulating cell motility. The biological activity of the peptide fragments is associated with their capability of binding and activating a neurotrophin receptor of the Trk family. The peptide fragments of the invention comprise an amino acid motif which is essential for binding and activating a neurotrophin receptor of the Trk family. The invention also concerns pharmaceutical compositions comprising the compounds and uses thereof for prevention and/or treatment of conditions and/or diseases, wherein neurotrophing, Tkr receptors and/or NCAM play an important role, and wherein stimulating of neurite outgrowth, cell survival, neural plasticity associated with memory and learning, and/or modulating cell motility is beneficial for treatment.
摘要翻译：本发明涉及能够刺激神经突生长，刺激细胞存活，刺激与记忆和学习相关的神经可塑性以及调节细胞运动性的新肽片段。肽片段的生物活性与其结合并激活Trk家族的神经营养因子受体的能力相关。本发明的肽片段包含对于结合并激活Trk家族的神经营养因子受体必需的氨基酸基序。本发明还涉及包含该化合物的药物组合物及其用于预防和/或治疗病症和/或疾病的用途，其中神经刺激素，Tkr受体和/或NCAM起重要作用，并且其中刺激神经突生长，细胞存活，神经元与记忆和学习相关的可塑性和/或调节细胞运动性对治疗是有益的。

10. 发明申请

WO2005123759A8 FGFR BINDING PEPTIDES 审中-公开
标题翻译： FGFR结合肽
公开(公告)号：WO2005123759A8
公开(公告)日：2006-03-09
申请号：PCT/DK2005000400
申请日：2005-06-17
申请人： ENKAM PHARMACEUTICALS AS , BOCK ELISABETH , BEREZIN VLADIMIR
发明人： BOCK ELISABETH , BEREZIN VLADIMIR
IPC分类号： C07K7/00 , C07K14/705 , A61K38/17 , A61P25/28 , C07K16/28
CPC分类号： C07K14/70503
摘要： The present invention relates to new peptide compounds capable of direct binding to fibroblast growth factor receptor (FGFR) and activating said receptor. The compounds of the invention comprise peptide fragments of the neural cell adhesion molecule (NCAM) derived from the fibronectin type-III module 1 (F3, 1) of NCAM. Peptide sequences of the invention are capable of stimulating learning and memory and/or neurite outgrowth and/or neural cell survival. Peptide sequences and compounds comprising thereof, according to the invention, may be beneficially used for treatment and/or prevention of different pathological conditions wherein FGFR and/or NCAM play a role in pathology and/or recovery from disease. Accordingly, pharmaceutical compositions comprising the peptide sequences and compounds of the invention are also in the scope of protection.
摘要翻译：本发明涉及能够直接结合成纤维细胞生长因子受体（FGFR）并激活所述受体的新肽化合物。本发明的化合物包含衍生自NCAM的纤连蛋白III型模块1（F3，1）的神经细胞粘附分子（NCAM）的肽片段。本发明的肽序列能够刺激学习和记忆和/或神经突生长和/或神经细胞存活。根据本发明的包含其的肽序列及其化合物可有利地用于治疗和/或预防其中FGFR和/或NCAM在病理学和/或疾病恢复中起作用的不同病理状况。因此，包含本发明的肽序列和化合物的药物组合物也在保护范围内。

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