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1. 发明申请

WO2012104490A1 A METHOD FOR DECOMPOSITION OF A COMPOSITE SIGNAL CONSISTING OF OSCILLATORY WAVEFORMS AND A MODULATING SIGNAL 审中-公开
标题翻译：一种分解振荡波形和调制信号的复合信号分解方法
公开(公告)号：WO2012104490A1
公开(公告)日：2012-08-09
申请号：PCT/FI2012/050099
申请日：2012-02-02
申请人： TTY-SÄÄTIÖ , SEPPÄ, Ville-Pekka , VIIK, Jari , HYTTINEN, Jari
发明人： SEPPÄ, Ville-Pekka , VIIK, Jari , HYTTINEN, Jari
IPC分类号： A61B5/08 , A61B5/0452
CPC分类号： A61B5/7207 , A61B5/0452 , A61B5/0535 , A61B5/0809 , A61B5/085 , A61B5/725
摘要： Various embodiments relate to a method, apparatus, system, and a computer program product for suppressing an oscillatory signal Sosc. In the method a composite signal S comprising said Soscand a modulating signal Smod are provided and the S is high pass filtered to produce estimates of the Sosc and the Smod,wherein the estimate of the Sosc comprises first oscillations during a first state of the modulating signal and second oscillations during a second state of the modulating signal. A first bin associated with said first state and a second bin associated with said second state are defined and assigned for said first oscillation and the second bin for said second oscillation according to a state defined from the estimate of the Smod.A first average waveform for said first oscillations and a second average waveform for said second oscillations are formed and used to suppress the Sosc signal from the composite signal S.
摘要翻译：各种实施例涉及用于抑制振荡信号Sosc的方法，装置，系统和计算机程序产品。在该方法中，提供包括所述Soscand的调制信号Smod的复合信号S，并且S被高通滤波以产生Sosc和Smod的估计，其中Sosc的估计包括在调制信号的第一状态期间的第一振荡以及在调制信号的第二状态期间的第二振荡。根据从Smod的估计定义的状态，定义并分配与所述第一状态相关联的第一仓和与所述第二状态相关联的第二仓，用于所述第一振荡和所述第二振荡的第二仓，所述第一振荡和所述第二振荡的第二平均波形被形成并用于抑制来自复合信号S的Sosc信号。

2. 发明申请

WO2017220868A1 VISUAL CARDIOMYOCYTE ANALYSIS 审中-公开
标题翻译：视觉心肌细胞分析
公开(公告)号：WO2017220868A1
公开(公告)日：2017-12-28
申请号：PCT/FI2017/050473
申请日：2017-06-22
申请人： TAMPEREEN YLIOPISTO , TTY-SÄÄTIÖ
发明人： MUHONEN, Ville , AHOLA, Antti , HYTTINEN, Jari
IPC分类号： G06T7/00 , G06K9/00 , G06T7/60
摘要： According to an example embodiment, a technique for estimating a biomechanical structure of one or more derived human cardiomyocytes (CMs) on basis of at least one image that represents the one or more derived human CMs is provided, the method comprising detecting respective image positions of predefined elements of the one or more derived human CMs, comprising detecting one or more first positions that indicate respective one or more adhesion points of a cell outline of the one or more derived human CMs where they attach to their substrate and detecting one or more second positions that indicate respective positions of one or more nuclei of the one or more derived human CMs; dividing the image representation of the one or more derived human CMs into a plurality of areas that represent respective sarcomeres of the one or more derived human CMs; and carrying out a further analysis of the one or more derived human CMs on basis of division of their image representation into said plurality of areas.
摘要翻译：根据示例实施例，提供了用于基于表示一个或多个派生的人类CM的至少一个图像来估计一个或多个派生的人类心肌细胞（CM）的生物力学结构的技术，所述方法包括检测所述一个或多个派生人CM的预定义元素的相应图像位置，包括检测指示所述一个或多个派生人CM的细胞轮廓的相应一个或多个附着点的一个或多个第一位置，它们的底物并检测一个或多个第二位置，所述一个或多个第二位置指示所述一个或多个衍生人CM的一个或多个核的各自位置; 将所述一个或多个派生的人CM的图像表示划分为表示所述一个或多个派生的人CM的相应的肌节的多个区域; 并且基于其图像表示划分为所述多个区域来对所述一个或多个派生的人CM进行进一步分析。

3. 发明申请

WO2014102449A1 VISUAL CARDIOMYOCYTE ANALYSIS 审中-公开
标题翻译：视觉心脏分析
公开(公告)号：WO2014102449A1
公开(公告)日：2014-07-03
申请号：PCT/FI2013/050905
申请日：2013-09-19
申请人： TAMPEREEN YLIOPISTO , TTY-SÄÄTIÖ
发明人： AALTO-SETÄLÄ, Katriina , LAHTI, Anna , HYTTINEN, Jari , AHOLA, Antti , HONKANEN, Markus , VENÄLÄINEN, Henna
IPC分类号： G06T7/00 , G06T7/20
CPC分类号： G06T7/246 , G01N33/4833 , G06T7/0016 , G06T7/11 , G06T7/223 , G06T2207/10016 , G06T2207/10056 , G06T2207/20021 , G06T2207/30024 , G06T2207/30048
摘要： A novel method for analyzing the beating of a derived human cardiomyocyte (CM) is provided. Said method comprises obtaining the derived human CM, capturing a sequence of images depicting the derived human CM over an analysis period, and determining at least one signal descriptive of the beating of the derived human CM during the analysis period on basis of the sequence of captured images. Furthermore, apparatuses, a computer program for analyzing the beating of a derived human CM and use thereof are provided, the apparatuses, the computer program and the use configured to provide for obtaining the sequence of images depicting the derived human CM over an analysis period, obtaining information indicative of the region of the images depicting the derived human CM, obtaining information indicative of two or more sub-regions within said region, and determining two or more signals characterizing the displacement within said region of the images depicting the derived human cardiomyocyte, each signal characterizing the extent of displacement within a respective sub-region of said region as a function of time.
摘要翻译：提供了一种用于分析衍生的人心肌细胞（CM）的跳动的新方法。所述方法包括获得导出的人CM，在分析期间捕获描绘所得人CM的图像序列，以及基于所捕获的序列确定在分析期间描述所导出的人CM的跳动的至少一个信号图片。此外，提供了用于分析导出的人类的CM的跳动的计算机程序及其使用的装置，所述装置，计算机程序和配置用于在分析周期内获得描绘所导出的人CM的图像序列，获取指示所述导出的人CM的图像的区域的信息，获得指示所述区域内的两个或更多个子区域的信息，以及确定描绘所述导出的人类心肌细胞的图像的所述区域内的位移的两个或更多个信号，每个信号表征作为时间的函数的所述区域的相应子区域内的位移程度。

4. 发明申请

WO2013001510A1 ARRANGEMENT FOR DEFINING A LOCATION WITHIN AN ORGANISM AND METHOD FOR MANUFACTURING A MANDRIN TO BE ACCOMMODATED IN A NEEDLE 审中-公开
标题翻译：用于定义有机体内的位置的装置以及用于制造将要接受的针头的方法
公开(公告)号：WO2013001510A1
公开(公告)日：2013-01-03
申请号：PCT/IB2012/053333
申请日：2012-06-29
申请人： INJEQ OY , KRONSTRÖM, Kai , KONTIOLA, Antti , PAASSILTA, Katja , AHONEN, Petri , HYTTINEN, Jari
发明人： KRONSTRÖM, Kai , KONTIOLA, Antti , PAASSILTA, Katja , AHONEN, Petri , HYTTINEN, Jari
IPC分类号： A61N1/08 , A61N1/05 , A61B5/06
CPC分类号： A61B5/068 , A61B5/0538 , A61B5/4887 , A61B5/6848 , A61B2562/125 , A61N1/0551 , A61N1/08
摘要： Arrangement for defining a location within an organism, said arrangement comprising: a hollow needle (2), comprising a longitudinal channel (5) and a distal end (4); a mandrin (1), accommodated in the longitudinal channel (5) in mobile manner in relation to it and removable from said channel (5) and having a distal and (3) of closed design, comprising an electrode pattern including at least two electrodes (7a, 7b, 7c, 7d); as well as a processing unit, configured to monitor the advancement of the distal end (4) only on the basis of a measurement signal of bioimpedance received from the electrodes (7a, 7b, 7c, 7d) of the electrode pattern. The application includes also an independent claim for a method for manufacturing a mandrin to be accommodated in a needle.
摘要翻译：用于限定生物体内的位置的装置，所述装置包括：中空针（2），包括纵向通道（5）和远端（4）; mand（1），以相对于其移动的方式容纳在所述纵向通道（5）中并且可从所述通道（5）移除并具有远端和（3）封闭设计，包括包括至少两个电极的电极图案（7a，7b，7c，7d）; 以及处理单元，其仅基于从电极图案的电极（7a，7b，7c，7d）接收的生物阻抗的测量信号来监视远端（4）的前进。本申请还包括用于制造要容纳在针中的mand的方法的独立权利要求。

5. 发明申请

WO2009083651A1 DETERMINING THE POSITION OF A NEEDLE 审中-公开
标题翻译：确定针头的位置
公开(公告)号：WO2009083651A1
公开(公告)日：2009-07-09
申请号：PCT/FI2008/050788
申请日：2008-12-29
申请人： PAASSILTA, Katja , SUURONEN, Riitta , HYTTINEN, Jari
发明人： PAASSILTA, Katja , SUURONEN, Riitta , HYTTINEN, Jari
IPC分类号： A61B5/053 , A61M5/46 , A61B1/01 , G01L1/00
CPC分类号： A61B5/053 , A61B5/063 , A61B5/415 , A61B5/418 , A61M5/3287 , A61M5/427
摘要： An arrangement for determining the position of a needle in an organ system and a method utilizing the arrangement in cosmetic treatment or cosmetic surgery. The arrangement (1) comprises a needle (2) with a distal tip (3), a measurement circuit (4) measuring the bioimpedance of tissues, a detection means (10) connected to the measurement circuit measuring bioimpedance and arranged to detect the progress of the distal tip (3) of the needle at a real-time basis from the bioimpedance measured from tissues. The arrangement (1) comprises at least two electrodes (16, 18, 21, 22) arranged at the distal tip (3) of the needle and connected to the measurement circuit (4). All the electrodes (16, 18, 21, 22) measuring impedance and needed for monitoring the progress of the distal tip (3) of the needle are arranged to the distal tip (3) of the needle.
摘要翻译：用于确定针在器官系统中的位置的装置以及在美容治疗或整容手术中利用该装置的方法。布置（1）包括具有远端尖端（3）的针（2），测量组织的生物阻抗的测量电路（4），连接到测量生物阻抗的测量电路的检测装置（10），并且被布置成检测进度根据从组织测量的生物阻抗实时地实现针的远端（3）。布置（1）包括布置在针的远端（3）处并连接到测量电路（4）的至少两个电极（16,18,21,22）。测量阻抗的所有电极（16,18,21,22）被布置在针的远端（3）上，用于监测针的远端尖端（3）的进展。

6. 发明申请

WO2012168534A1 DEVICE AND METHOD FOR MEASURING VIBRATION TRANSMITTANCE OF STERNUM 审中-公开
标题翻译：用于测量STERNUM的振动传递的装置和方法
公开(公告)号：WO2012168534A1
公开(公告)日：2012-12-13
申请号：PCT/FI2011/050543
申请日：2011-06-09
申请人： TAYS SYDÄNKESKUS OY , BEEV, Nikolai , HAUTALAHTI, Juha , LAURIKKA, Jari , TARKKA, Matti , HYTTINEN, Jari
发明人： BEEV, Nikolai , HAUTALAHTI, Juha , LAURIKKA, Jari , TARKKA, Matti , HYTTINEN, Jari
IPC分类号： A61B8/08 , A61B5/103
CPC分类号： A61B5/0051 , A61B5/4504 , A61B5/4538 , A61B5/6823
摘要： The invention relates to a method, device and system for measuring vibration transmittance of a sternum noninvasively. The method comprises producing vibration, transmitting the vibration to a first side the sternum through skin and soft tissues, obtaining response data of the sternum from a second side of the sternum through skin and soft tissues, which first and second sides of the sternum are on different sides of the midline of the sternum, and processing said response data for determining transmittance of vibration of the sternum. The response data may be used for defining state of a patient such as sternal instability of the breastbone or abnormal healing in the sternum after open chest surgery by surgeons.
摘要翻译：本发明涉及非侵入式地测量胸骨的振动透射率的方法，装置和系统。该方法包括产生振动，通过皮肤和软组织将振动传递到胸骨的第一侧，通过皮肤和软组织从胸骨的第二侧获得胸骨的反应数据，胸骨的第一和第二侧在其上在胸骨中线的不同侧面处理所述反应数据，以确定胸骨振动的透射率。响应数据可以用于定义患者的状态，例如胸骨的胸骨不稳定性或外科医生开胸手术后胸骨异常愈合。

7. 发明申请

WO2010079257A1 A DEVICE, AN APPARATUS AND A METHOD FOR MEASURING BIOLOGICAL INFORMATION 审中-公开
标题翻译：装置，装置和测量生物信息的方法
公开(公告)号：WO2010079257A1
公开(公告)日：2010-07-15
申请号：PCT/FI2009/050007
申请日：2009-01-07
申请人： Tampereen teknillinen yliopisto , LEKKALA, Jukka , HYTTINEN, Jari
发明人： LEKKALA, Jukka , HYTTINEN, Jari
IPC分类号： A61B5/024 , A61B5/0402 , A61B5/0404 , A61B5/00
CPC分类号： A61B5/0402 , A61B5/0205 , A61B5/02438 , A61B5/026 , A61B5/0476 , A61B5/053 , A61B5/6815 , A61B5/6838 , A61B5/6887
摘要： The invention relates to a device, comprising, at least two earpieces configured to be inserted in both ear canals or in close proximity to both ear canals, and at least two sensors being integrated into earpieces, said sensors being configured to measure biological signal patterns simultaneously from both ears of the user. The invention further relates to an apparatus, comprising the measuring device, at least one processing unit configured to process the biological signal data,at least one output unit configured to provide information based on the biological signal data and said at least one measurement device, said at least one processing unit and said at least one output unit being configured to communicate the biological signal data with each other. This invention also relates to a method for measuring biologic signal patterns simultaneously from both ears.
摘要翻译：本发明涉及一种装置，包括：至少两个耳机，被配置为插入在两个耳道中或者紧邻两个耳道，并且至少两个传感器被集成到听筒中，所述传感器被配置成同时测量生物信号图案从用户的双耳。本发明还涉及一种装置，包括测量装置，配置成处理生物信号数据的至少一个处理单元，配置成基于生物信号数据和所述至少一个测量装置提供信息的至少一个输出单元，所述至少一个至少一个处理单元和所述至少一个输出单元被配置为将生物信号数据彼此通信。本发明还涉及一种从双耳同时测量生物信号模式的方法。

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