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1. 发明申请

WO2012054582A2 SILK FIBROIN-BASED MICRONEEDLES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：基于丝基纤维素的麦克风及其制备方法
公开(公告)号：WO2012054582A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056856
申请日：2011-10-19
申请人： TRUSTEES OF TUFTS COLLEGE , KAPLAN, David L. , TSIORIS, Konstantinos , OMENETTO, Fiorenzo G. , PRITCHARD, Eleanor M.
发明人： KAPLAN, David L. , TSIORIS, Konstantinos , OMENETTO, Fiorenzo G. , PRITCHARD, Eleanor M.
IPC分类号： A61M37/00 , A61M5/158 , A61L27/58
CPC分类号： A61L31/125 , A61B17/205 , A61K9/0021 , A61L31/047 , A61L31/16 , A61M5/158 , A61M37/0015 , A61M2037/0046 , A61M2037/0053
摘要： A microneedle or microneedle device includes a microneedle body extending from a base to a penetrating tip formed from a silk fibroin based material, which is easy to fabricate and highly biocompatible. The microneedle device can include one or more microneedles mounted to a substrate. The silk fibroin can include active agents to be transported into or across biological barriers such as skin, tissue and cell membranes. The silk fibroin microneedles can be fully or partially biodegradable and/or bioerodible. The silk fibroin is highly stable, affords room temperature storage and is implantable. The silk fibroin structure can be modulated to control the rate of active agent delivery.
摘要翻译：微针或微针装置包括从基部延伸到由丝素蛋白基材料形成的穿透尖端的微针体，其易于制造和高度生物相容性。微针装置可以包括安装到基底的一个或多个微针。丝素蛋白可以包括被运送到生物屏障如皮肤，组织和细胞膜之中或之上的活性剂。丝素蛋白微针可以全部或部分生物降解和/或生物侵蚀。丝素蛋白高度稳定，提供室温储存并可植入。可以调节丝素蛋白结构以控制活性剂递送的速率。

2. 发明申请

WO2018013612A1 ARTIFICIAL BRAIN TISSUE 审中-公开
标题翻译：人造大脑组织
公开(公告)号：WO2018013612A1
公开(公告)日：2018-01-18
申请号：PCT/US2017/041599
申请日：2017-07-11
申请人： TRUSTEES OF TUFTS COLLEGE
发明人： KAPLAN, David L. , CANTLEY, William , LIAUDANSKAYA, Volha , SOOD, Disha , DINGLE, Yu-Ting , COLLINS, William , OMENETTO, Fiorenzo G.
IPC分类号： A61F2/00 , A61F2/02 , A61K9/00 , A61K9/70 , A61K35/19 , A61K35/28 , A61K35/44
摘要： The present invention provides, among other things, powerful new tools for therapeutic and research uses in the central and/or peripheral nervous system. The present invention provides, inter alia , compositions including a plurality of human nerve cells, a plurality of glial cells, and silk fibroin, as well as methods for making and using such compositions.
摘要翻译：除其他外，本发明提供了用于中枢和/或外周神经系统中的治疗和研究用途的强大的新工具。本发明特别提供了包含多种人神经细胞，多种神经胶质细胞和丝素蛋白的组合物，以及制备和使用这种组合物的方法。

3. 发明申请

WO2017123383A3 SILK-FIBROIN HYDROGELS, METHODS OF FORMING, AND USES THEREOF 审中-公开
公开(公告)号：WO2017123383A3
公开(公告)日：2017-07-20
申请号：PCT/US2016/067269
申请日：2016-12-16
申请人： TRUSTEES OF TUFTS COLLEGE
发明人： OMENETTO, Fiorenzo G. , APPLEGATE, Matthew B. , KAPLAN, David L.
IPC分类号： A61F2/00 , A61L27/22 , A61L27/56
摘要： The present disclosure provides transparent, elastic silk hydrogels for applications, including corneal reshaping to restore visual acuity and photolithography. The present disclosure also provides methods of photocrosslinking silk fibroin protein using riboflavin as a photoinitiator and exposing such riboflavin doped silk fibroin to light resulting in the formation of a transparent, elastic hydrogel.

4. 发明申请

WO2020068243A1 SYSTEMS AND METHODS FOR A REMOTE CONTROL ACTUATOR 审中-公开
公开(公告)号：WO2020068243A1
公开(公告)日：2020-04-02
申请号：PCT/US2019/040430
申请日：2019-07-02
申请人： TRUSTEES OF TUFTS COLLEGE
发明人： OMENETTO, Fiorenzo G. , LI, Meng
IPC分类号： F03G7/06 , H01H37/32 , H01H37/58
摘要： The present application relates to compositions and methods of making flexible composite materials that are capable of moving, on a micro- or macro-scale, in response to an applied magnetic field and localized heat from a heat source. The present disclosure further provides systems and methods of using the flexible composite material as an actuator for performing a mode of actuation. In one embodiment, the flexible composite material forms a wireless actuator that, when irradiated with light, is capable of micro- and macro-scale motion acting through the interplay of optically absorptive elements and low-Curie temperature magnetic particles.

5. 发明申请

WO2017123383A2 SILK-FIBROIN HYDROGELS, METHODS OF FORMING, AND USES THEREOF 审中-公开
标题翻译：丝蛋白水凝胶，形成方法及其用途
公开(公告)号：WO2017123383A2
公开(公告)日：2017-07-20
申请号：PCT/US2016/067269
申请日：2016-12-16
申请人： TRUSTEES OF TUFTS COLLEGE
发明人： OMENETTO, Fiorenzo G. , APPLEGATE, Matthew B. , KAPLAN, David L.
IPC分类号： A61F2/16 , A61K38/17
CPC分类号： A61F2/14 , A61K38/00
摘要： The present disclosure provides transparent, elastic silk hydrogels for applications, including corneal reshaping to restore visual acuity and photolithography. The present disclosure also provides methods of photocrosslinking silk fibroin protein using riboflavin as a photoinitiator and exposing such riboflavin doped silk fibroin to light resulting in the formation of a transparent, elastic hydrogel.
摘要翻译：本公开提供用于应用的透明弹性丝绸水凝胶，包括角膜重塑以恢复视敏度和光刻。本发明还提供了使用核黄素作为光引发剂使光致交联丝素蛋白的方法，并将这种核黄素掺杂的丝素蛋白暴露于光下，导致形成透明的弹性水凝胶。

6. 发明申请

WO2018026853A1 BIOMIMETIC MECHANICAL TENSION DRIVEN FABRICATION OF NANOFIBRILLAR ARCHITECTURE 审中-公开
标题翻译：生物医学机械张力驱动纳米纤维结构的研制
公开(公告)号：WO2018026853A1
公开(公告)日：2018-02-08
申请号：PCT/US2017/044960
申请日：2017-08-01
申请人： TRUSTEES OF TUFTS COLLEGE
发明人： OMENETTO, Fiorenzo G. , TSENG, Peter
IPC分类号： B82Y30/00 , B82Y40/00 , B82B1/00 , B82B3/00 , D01F4/00 , D01F4/02
摘要： This present disclosure provides methods for utilizing such forces in when generating nanofibrillar constructs with engineered morphology from the nano- to macro-scales. Using for example, a biopolymer silk fibroin as a base material, patterns of an intermediate hydrogel were generated within a deformable mold. Subsequently, mechanical tension was introduced via either hydrogel contraction or mold deformation, and finally a material is reentrapped in this transformed shape via beta-sheet crystallization and critical point drying. Topdown engineered anchorages, cables, and shapes act in concert to mediate precision changes in nanofiber alignment/orientation and a macroscale form of provided nanofibrillar structure. An ability of this technique to engineer large gradients of nano- and micro-scale order, manipulate mechanical properties (such as plasticity and thermal transport), and the in-situ generation of 2D and 3D, multi-tiered and doped, nanofibrillar constructs was demonstrated.
摘要翻译：本发明提供了在产生具有从纳米级到宏观级的工程化形态的纳米原纤维构建体时利用这些力的方法。使用例如生物聚合物丝心蛋白作为基础材料，在可变形的模具内生成中间水凝胶的图案。随后，通过水凝胶收缩或模具变形引入机械张力，最后通过β-片层结晶和临界点干燥将材料重新包裹在该转变形状中。自顶向下设计的锚固点，电缆和形状协调一致地调解纳米纤维排列/取向的精确变化以及所提供的纳米纤丝结构的宏观形式。该技术能够设计纳米级和微米级的大梯度，操纵机械性能（如塑性和热传递），以及2D和3D，多层和掺杂的纳米纤丝结构的原位生成是证实。

7. 发明申请

WO2020198648A1 REVERSIBLE WRINKLE PATTERNS AND METHODS OF MAKING AND USING THE SAME 审中-公开
公开(公告)号：WO2020198648A1
公开(公告)日：2020-10-01
申请号：PCT/US2020/025386
申请日：2020-03-27
申请人： TRUSTEES OF TUFTS COLLEGE
发明人： OMENETTO, Fiorenzo G. , WANG, Yu , KIM, Beom Joon
IPC分类号： A61K41/00 , A61K47/42 , A61K9/10
摘要： The present disclosure relates to reversibly wrinkled silk-based compositions. The provided compositions are tunable and the reversible wrinkles are sensitive to water vapor, methanol vapor, and UV irradiation. The present disclosure also provides methods for making and using the same.

8. 发明申请

WO2020068243A9 SYSTEMS AND METHODS FOR A REMOTE CONTROL ACTUATOR 审中-公开
公开(公告)号：WO2020068243A9
公开(公告)日：2020-04-02
申请号：PCT/US2019/040430
申请日：2019-07-02
申请人： TRUSTEES OF TUFTS COLLEGE
发明人： OMENETTO, Fiorenzo G. , LI, Meng
IPC分类号： F03G7/06 , H01H37/32 , H01H37/58
摘要： The present application relates to compositions and methods of making flexible composite materials that are capable of moving, on a micro- or macro-scale, in response to an applied magnetic field and localized heat from a heat source. The present disclosure further provides systems and methods of using the flexible composite material as an actuator for performing a mode of actuation. In one embodiment, the flexible composite material forms a wireless actuator that, when irradiated with light, is capable of micro- and macro-scale motion acting through the interplay of optically absorptive elements and low-Curie temperature magnetic particles.

9. 发明申请

WO2018006037A1 INNERVATED ARTIFICIAL SKIN 审中-公开
标题翻译：保护性人造皮肤
公开(公告)号：WO2018006037A1
公开(公告)日：2018-01-04
申请号：PCT/US2017/040423
申请日：2017-06-30
申请人： TRUSTEES OF TUFTS COLLEGE
发明人： KAPLAN, David L. , VIDAL, Sarah Lightfoot , ABBOT, Rosalyn , ZHAO, Siwei , CAIRNS, Dana , OMENETTO, Fiorenzo G.
IPC分类号： C12N5/00 , C12N5/071 , C12N5/16
摘要： The present invention provides, in some embodiments, multi-layer silk compositions including a first layer comprising silk fibroin and keratinocytes, a second layer comprising silk fibroin and fibroblasts, a third layer comprising silk fibroin and adipocytes, and a plurality of nervous system cells, wherein at least some of the plurality of nervous system cells span at least two layers, and methods of making and using the same. In some embodiments, provided methods and compositions further include immune cells and/or endothelial cells.
摘要翻译：在一些实施方案中，本发明提供多层丝组合物，其包含含丝素蛋白和角质形成细胞的第一层，含丝素蛋白和成纤维细胞的第二层，含丝素蛋白和脂肪细胞的第三层，和多个神经系统细胞，其中所述多个神经系统细胞中的至少一些跨越至少两个层，以及制造和使用它们的方法。在一些实施方案中，提供的方法和组合物还包含免疫细胞和/或内皮细胞。

10. 发明申请

WO2017019841A1 POLYPEPTIDE MONOLITHS 审中-公开
标题翻译：多肽单体
公开(公告)号：WO2017019841A1
公开(公告)日：2017-02-02
申请号：PCT/US2016/044411
申请日：2016-07-28
申请人： TRUSTEES OF TUFTS COLLEGE
发明人： OMENETTO, Fiorenzo G. , KAPLAN, David L. , MARELLI, Benedetto , LI, Chunmei
IPC分类号： A61K47/32 , A61K47/42 , A61L27/14 , A61L27/22
CPC分类号： A61K47/32 , A61K47/42 , A61L27/22 , A61L27/227 , A61L27/46 , A61L27/54 , A61L27/56
摘要： The present application relates to amphiphilic polypeptide materials, methods for making and using the same. Provided amphiphilic polypeptide materials are water-based and manufactured using all aqueous processing. Provided materials exhibit a capacity to encapsulate and store biologically active molecules or macromolecules. Such biologically active molecules or macromolecules retain their structure and the biological activity so that these biologically active molecules or macromolecules are not materially degraded, reduced, and/or inhibited by processing steps or exposure. Provided materials possess unique mechanical and structural properties, including size, density, moldability and machinability.
摘要翻译：本申请涉及两亲多肽材料，其制备和使用方法。提供的两亲多肽材料是水性的并且使用所有水性处理制造。所提供的材料具有包封和储存生物活性分子或大分子的能力。这样的生物活性分子或大分子保留其结构和生物活性，使得这些生物活性分子或大分子不会被加工步骤或暴露物质降解，降低和/或抑制。提供的材料具有独特的机械和结构性能，包括尺寸，密度，成型性和可加工性。

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