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1. 发明申请

WO2008157683A1 METHOD AND SYSTEM FOR TREATING OF ONYCHOMYCOSIS WITH AN APPLICATOR HAVING A GEL MEDICAMENT LAYER 审中-公开
标题翻译：用具有凝胶药物层的应用者治疗骨质疏松症的方法和系统
公开(公告)号：WO2008157683A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/067482
申请日：2008-06-19
申请人： TRANSPORT PHARMACEUTICALS, INC. , CHAKRABORTY, Bireswar , BARSNESS, Michael, S. , GOLDBERG, Dennis, I. , ETHEREDGE, Robert, W. , DAVIS, Shawn, P.
发明人： CHAKRABORTY, Bireswar , BARSNESS, Michael, S. , GOLDBERG, Dennis, I. , ETHEREDGE, Robert, W. , DAVIS, Shawn, P.
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61F13/068 , A61F13/105 , A61N1/0424 , A61N1/044
摘要： A method to electrokinetically deliver a medicament to a nail of a mammalian user including: forming a cast of the nail of the user wherein the cast is a reverse impression of the nail; applying a medicament matrix to the nail; sandwiching the medicament matrix between the cast and the nail; pressing the medicament matrix to the nail using the cast; applying electrical current to an electrical current path extending through the medicament matrix and the nail, and delivering medicament from the matrix into the nail by electrokinetic transporting the medicament along the current path.
摘要翻译：一种将药物电动地递送到哺乳动物使用者的指甲的方法，包括：形成使用者的指甲的铸件，其中铸件是指甲的反向印象; 将药物基质施用于指甲; 将药物基质夹在铸件和钉子之间; 使用铸件将药物基质压到指甲上; 将电流施加到延伸穿过药物基质和钉子的电流通道，以及通过沿着电流路径电动转运药物将药物从基质输送到钉子中。

2. 发明申请

WO2008157485A1 CURRENT CONCENTRATION SYSTEM AND METHOD FOR ELECTROKINETIC DELIVERY OF MEDICAMENTS 审中-公开
标题翻译：电流传递系统和方法用于药物输送
公开(公告)号：WO2008157485A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/067107
申请日：2008-06-16
申请人： TRANSPORT PHARMACEUTICALS, INC. , DAVIS, Shawn, P. , BARSNESS, Michael, S. , GOLDBERG, Dennis, I. , CHAKRABORTY, Bireswar , ETHEREDGE, Robert, W.
发明人： DAVIS, Shawn, P. , BARSNESS, Michael, S. , GOLDBERG, Dennis, I. , CHAKRABORTY, Bireswar , ETHEREDGE, Robert, W.
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0424 , A61N1/0448
摘要： An electrokinetic apparatus to apply medicament to a treatment site of a mammalian user, the apparatus including: a flux concentrator including an active electrode and a counter electrode adapted to be applied to the surface of a toenail or fingernail of the user, and a medicament matrix adjacent the active electrode and arranged to be sandwiched between the active electrode and nail.
摘要翻译：一种用于将药物施用于哺乳动物使用者的治疗部位的电动装置，所述装置包括：通量集中器，其包括适于施加到使用者的趾甲或指甲的表面的活性电极和对电极，以及药物基质邻近有源电极并且布置成夹在有源电极和钉子之间。

3. 发明申请

WO2008157481A1 METHOD AND SYSTEM FOR MITIGATING CURRENT CONCENTRATION IN ELECTROKINETIC DRUG DELIVERY 审中-公开
标题翻译：用于减轻电动药物输送中电流浓度的方法和系统
公开(公告)号：WO2008157481A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/067102
申请日：2008-06-16
申请人： TRANSPORT PHARMACEUTICALS, INC. , CHANG, Kuowei , GOLDBERG, Dennis, I. , ETHEREDGE, Robert, W. , BARSNESS, Michael, S.
发明人： CHANG, Kuowei , GOLDBERG, Dennis, I. , ETHEREDGE, Robert, W. , BARSNESS, Michael, S.
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0412 , A61N1/0424 , A61N1/0428 , A61N1/0448
摘要： An electrokinetic apparatus to apply medicament to a treatment site of a mammalian user, the apparatus including: a segmented active electrode; a medicament matrix having one side abutting the segmented active electrode and another side adapted to contact a surface of skin over the treatment site, wherein the matrix includes at least one current direction barrier suppressing transverse current flow through the matrix.
摘要翻译：一种用于将药物施用于哺乳动物使用者的治疗部位的电动装置，所述装置包括：分段活性电极; 药物基质，其一侧邻接所述分段的活性电极，另一侧适于在所述治疗部位接触皮肤表面，其中所述基质包括至少一个电流方向屏障，其阻止穿过所述基质的横向电流。

4. 发明申请

WO2007064722A1 AN APPLICATOR CARTRIDGE FOR AN ELECTROKINETIC DELIVERY SYSTEM FOR SELF ADMINISTRATION OF MEDICAMENTS 审中-公开
标题翻译：用于自我管理药物的电动输送系统的应用程序盒
公开(公告)号：WO2007064722A1
公开(公告)日：2007-06-07
申请号：PCT/US2006/045719
申请日：2006-11-30
申请人： TRANSPORT PHARMACEUTICALS, INC. , PETERSEN, John, S. , GOLDBERG, Dennis, I. , KELLAND, James, W. , ETHEREDGE, Robert, W. , BARNESS, Michael, S. , CHANG, Kuowei
发明人： PETERSEN, John, S. , GOLDBERG, Dennis, I. , KELLAND, James, W. , ETHEREDGE, Robert, W. , BARNESS, Michael, S. , CHANG, Kuowei
IPC分类号： A61N1/30
CPC分类号： A61N1/303
摘要： An applicator for a device for electrokinetic delivery of medicament to a treatment site includes an applicator head having an active electrode, a matrix, and a medicament or a medicament and an electrically conductive carrier, carried by the matrix in electrical contact with the electrode. The cartridge includes a plurality of raised projections allowing the matrix and head to be ultrasonically welded one to the other. The electrode opens through a face of the head remote from the matrix for connection with an electrical connector carried by the device. A lid overlies the matrix and is releasably attached to a margin of the head. The lid includes layers of different materials with one of the layers formed of a metallic material having a discontinued interface with the lid and a tab carried by the lid.
摘要翻译：用于将药物电动递送到治疗部位的装置的施加器包括具有活性电极，基质以及由电极与电极电接触的基质携带的药物或药物和导电载体的施用器头。盒包括多个凸起突起，允许矩阵和头被彼此超声波焊接。电极通过远离矩阵的头部的面打开，以与由该装置承载的电连接器连接。盖子覆盖在基体上并且可释放地附接到头部的边缘。盖子包括不同材料的层，其中一层由金属材料形成，该金属材料具有与盖不连续的界面和由盖承载的突片。

5. 发明申请

WO2008131205A1 A SINGLE USE APPLICATOR CARTRIDGE FOR AN ELECTROKINETIC DELIVERY SYSTEM AND METHOD FOR SELF ADMINISTRATION OF MEDICAMENTS 审中-公开
标题翻译：用于电动输送系统的单个使用者盒子和用于自我管理药物的方法
公开(公告)号：WO2008131205A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/060798
申请日：2008-04-18
申请人： TRANSPORT PHARMACEUTICALS, INC. , BARSNESS, Michael, S. , ETHEREDGE, Robert, W.
发明人： BARSNESS, Michael, S. , ETHEREDGE, Robert, W.
IPC分类号： A61N1/30
CPC分类号： A61N1/0428 , A61N1/0436 , A61N1/044 , A61N1/0448
摘要： An applicator cartridge for use with a device for electrokinetically delivering a medicament to a treatment site, the cartridge including: an applicator head including an active electrode, and a conductive path extending between a pair of electrical contacts, wherein the electrical contacts electrically engage respective contacts on the device when the cartridge is inserted into the device; a matrix support surface of said applicator head adjacent the active electrode; a matrix attached to the matrix support surface and in contact with the active electrode, the matrix having an exposed surface adapted to be applied to the treatment site; a medicament or a medicament and an electrically conductive carrier carried by said matrix; a removable lid covering the exposed surface of the matrix and sealed to the applicator head, the lid is conductively coupled to the applicator head and completes the conductive path on the applicator head, wherein removal of the lid breaks the conductive path.
摘要翻译：一种用于与用于将药物电动地递送到治疗部位的装置一起使用的涂抹器盒，所述药筒包括：施用头，其包括有源电极，以及在一对电触点之间延伸的导电路径，其中所述电触点电接合相应的触点当墨盒插入设备时在设备上; 邻近活性电极的所述施用器头部的基质支撑表面; 连接到基质支持表面并与活性电极接触的基质，所述基质具有适于施用于治疗部位的暴露表面; 由所述基质携带的药物或药物和导电载体; 一个可移除的盖，其覆盖基体的暴露表面并且密封到施用器头上，该盖与施加器头导电地联接，并且完成施加器头上的导电路径，其中盖的移除打破了导电路径。

6. 发明申请

WO2007064723A1 COMBINATION CARTRIDGE AND DEVICE FOR ELECTROKINETIC DELIVERY OF MEDICAMENT TO A TREATMENT SITE 审中-公开
标题翻译：组合式药盒和用于向治疗场地进行药物输送的装置
公开(公告)号：WO2007064723A1
公开(公告)日：2007-06-07
申请号：PCT/US2006/045720
申请日：2006-11-30
申请人： TRANSPORT PHARMACEUTICALS, INC. , GLAXOSMITHKLINE UK LIMITED , PETERSEN, John, S. , GOLDBERG, Dennis, I. , KELLAND, James W. , RAND, Paul, K. , JONES, Anthony, Patrick Charles , ETHEREDGE, Robert, W.
发明人： PETERSEN, John, S. , GOLDBERG, Dennis, I. , KELLAND, James W. , RAND, Paul, K. , JONES, Anthony, Patrick Charles , ETHEREDGE, Robert, W.
IPC分类号： A61N1/30
CPC分类号： A61N1/303
摘要： A device for electrokinetic delivery of medicament to a treatment site includes a cartridge having an active electrode and a membrane overlying the active electrode and a medicament or a medicament and an electrically conductive carrier therefor, carried by the membrane in electrical contact with the electrode. The electrode opens through a surface of the cartridge remote from the membrane for connection with an electrical connector carried by the device. An locking element releasably couples the cartridge to the housing.
摘要翻译：用于将药物电动递送到治疗部位的装置包括具有活性电极和覆盖有源电极的膜的药筒以及与电极电接触的膜携带的药物或药物及其导电载体。电极通过远离膜的盒的表面打开，以与由装置承载的电连接器连接。锁定元件可释放地将盒连接到壳体。

7. 发明申请

WO2007035710A2 ELECTROKINETIC DELIVERY SYSTEM AND METHODS THEREFOR 审中-公开
标题翻译：电动输送系统及其方法
公开(公告)号：WO2007035710A2
公开(公告)日：2007-03-29
申请号：PCT/US2006/036438
申请日：2006-09-19
申请人： TRANSPORT PHARMACEUTICALS, INC. , ETHEREDGE, Robert, W. , GOLDBERG, Dennis, I. , FRIDEN, Phillip, M. , PETERSON, John, S.
发明人： ETHEREDGE, Robert, W. , GOLDBERG, Dennis, I. , FRIDEN, Phillip, M. , PETERSON, John, S.
IPC分类号： A61B17/20
CPC分类号： A61B17/205 , A61M37/0015
摘要： The electrokinetic medicament delivery system includes at least one applicator having a multiplicity of non-conductive micro-needles carried on a non-conductive surface of the applicator. The opposite surface is formed of electrically conductive material for contact with an active electrode. The applicator includes a matrix containing a medicament or a carrier therefor between the opposite surfaces. When the applicator is applied to the individual's skin with the micro-needles penetrating the skin, an electrical current is completed through the power source, the active electrode, medicament, or electrically conductive carrier therefor, the targeted treatment site, the individual's body, a ground electrode and the power supply, thereby electrokinetically driving the medicament through the non-conductive micro-needles into the targeted treatment site.
摘要翻译：电动药物输送系统包括至少一个涂药器，其具有承载在涂药器的非导电表面上的多个不导电微针。相对表面由导电材料形成以用于与有源电极接触。敷抹器包括在相对表面之间包含药物或载体的基质。当施用器用微针穿透皮肤施用于个人的皮肤时，通过电源，活性电极，药物或其导电载体，目标治疗部位，个体的身体，a 接地电极和电源，从而通过非导电微针电动地驱动药物进入目标治疗部位。

8. 发明申请

WO2010083340A1 METHOD AND SYSTEM FOR MITIGATING CURRENT CONCENTRATION IN ELECTROKINETIC DRUG DELIVERY 审中-公开
标题翻译：用于减轻电动药物输送中电流浓度的方法和系统
公开(公告)号：WO2010083340A1
公开(公告)日：2010-07-22
申请号：PCT/US2010/021083
申请日：2010-01-14
申请人： NITRIC BIOTHERAPEUTICS, INC. , ETHEREDGE, Robert, W. , BARSNESS, Michael, S.
发明人： ETHEREDGE, Robert, W. , BARSNESS, Michael, S.
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61N1/303
摘要： An electrokinetic apparatus to apply medicament to a treatment site of a mammalian user, the apparatus including: a segmented active electrode; a medicament matrix having one side abutting the segmented active electrode and another side adapted to contact a surface of skin over the treatment site, wherein the matrix includes at least one current direction barrier suppressing transverse current flow through the matrix.
摘要翻译：一种用于将药物施用于哺乳动物使用者的治疗部位的电动装置，所述装置包括：分段活性电极; 药物基质，其一侧邻接所述分段的活性电极，另一侧适于在所述治疗部位接触皮肤表面，其中所述基质包括至少一个电流方向屏障，其阻止穿过所述基质的横向电流。

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