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1. 发明申请

WO2008133900A1 QUATERNARY AMMONIUM COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：季铵化合物作为MUSCARINIC受体拮抗剂有用
公开(公告)号：WO2008133900A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/005224
申请日：2008-04-23
申请人： THERAVANCE, INC. , HUSFELD, Craig , JI, Yu-hua , LEE, Rick , LI, Li , MU, Yongqi , SMITH, Cameron , UY, Johnny
发明人： HUSFELD, Craig , JI, Yu-hua , LEE, Rick , LI, Li , MU, Yongqi , SMITH, Cameron , UY, Johnny
IPC分类号： C07D205/04 , C07D211/26 , C07D211/58 , C07D401/12 , C07D409/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/14 , A61K31/4468 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/397 , A61P11/06
CPC分类号： C07D409/14 , C07D205/04 , C07D211/26 , C07D211/58 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12
摘要： The invention provides compounds of the formula: (I) in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R 1-6 , a, Z and Q are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
摘要翻译：本发明提供式（I）盐或两性离子形式的化合物或其药学上可接受的盐，其中R 1-6，a，Z和Q如说明书中所定义。这些化合物是毒蕈碱受体拮抗剂。本发明还提供含有这些化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺疾病的方法。

2. 发明申请

WO2009079392A1 AMIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：含有AMIDINE的化合物作为MUSCARINIC受体拮抗剂有用
公开(公告)号：WO2009079392A1
公开(公告)日：2009-06-25
申请号：PCT/US2008/086645
申请日：2008-12-12
申请人： THERAVANCE, INC. , JI, Yu-Hua , HUSFELD, Craig , LEE, Rick , MU, Yongqi , SMITH, Cameron
发明人： JI, Yu-Hua , HUSFELD, Craig , LEE, Rick , MU, Yongqi , SMITH, Cameron
IPC分类号： C07D207/12 , C07D211/58 , C07D409/12 , C07D295/195 , A61K31/40 , A61K31/4468 , A61K31/495 , A61K31/496 , A61P11/06 , A61P11/08
CPC分类号： C07D295/195 , C07D207/12 , C07D211/58 , C07D409/12
摘要： The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, where R 1-3 , R 5 , R 7 , a, b, Q, X, X', X'', Y, Z, and Ar are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also relates to pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中R1-3，R5，R7，a，b，Q，X，X'，X“，Y，Z和Ar为在规范中定义。这些化合物是毒蕈碱受体拮抗剂。本发明还涉及含有这种化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺病的方法。

3. 发明申请

WO2008103426A1 QUATERNARY AMMONIUM DIPHENYLMETHYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：季戊四醇二甲苯化合物可用作肌酐受体拮抗剂
公开(公告)号：WO2008103426A1
公开(公告)日：2008-08-28
申请号：PCT/US2008/002321
申请日：2008-02-21
申请人： THERAVANCE, INC. , JI, Yu-hua , HUSFELD, Craig , LANGE, Christopher , LEE, Rick , MU, Yongqi
发明人： JI, Yu-hua , HUSFELD, Craig , LANGE, Christopher , LEE, Rick , MU, Yongqi
IPC分类号： C07D207/08 , C07D207/09 , A61K31/40 , A61P11/00
CPC分类号： C07D207/09 , C07D207/08 , C07D207/48
摘要： The invention provides compounds of formula (I) in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R 1-6 , a-e and Q are as defined in the specification,. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
摘要翻译：本发明提供盐或两性离子形式的式（I）化合物或其药学上可接受的盐，其中R 1-6，a-e和Q如说明书中所定义。这些化合物是毒蕈碱受体拮抗剂。本发明还提供含有这些化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺疾病的方法。

4. 发明申请

WO2009035542A2 GUANIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：含胍的化合物可用作麦考酚受体拮抗剂
公开(公告)号：WO2009035542A2
公开(公告)日：2009-03-19
申请号：PCT/US2008/010431
申请日：2008-09-05
申请人： THERAVANCE, INC. , JI, Yu-Hua , HUSFELD, Craig , MU, YongQi , LEE, Rick , LI, Li
发明人： JI, Yu-Hua , HUSFELD, Craig , MU, YongQi , LEE, Rick , LI, Li
IPC分类号： C07D209/14 , C07D213/38 , C07D231/12 , C07D277/28
CPC分类号： C07D333/24 , C07D209/14 , C07D213/38 , C07D231/12 , C07D277/28 , C07D295/13 , C07D307/52 , C07D307/81 , C07D317/58 , C07D333/20 , C07D333/58
摘要： The invention provides compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1-3 , R 5-7 , a, X, Y, Y', Y'', and Z are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
摘要翻译：本发明提供了式（I）的化合物或其药学上可接受的盐，其中R 1至R 3，R 5至R 7，，X，Y，Y'，Y“和Z如说明书中所定义。这些化合物是毒蕈碱受体拮抗剂。本发明还提供了含有这些化合物的药物组合物，制备这些化合物的方法以及使用这些化合物来治疗例如慢性阻塞性肺病和哮喘等肺部疾病的方法。

5. 发明申请

WO2003031288A2 INDUCTION DRIVE FOR INDUCTION DRIVEN CONVEYOR 审中-公开
标题翻译：用于感应驱动输送机的感应驱动
公开(公告)号：WO2003031288A2
公开(公告)日：2003-04-17
申请号：PCT/US2002/030225
申请日：2002-09-24
申请人： LEE, Rick
发明人： LEE, Rick
IPC分类号： B65G
CPC分类号： H02K41/03 , B65G15/02 , B65G23/23 , H02K1/27
摘要： Induction drives for either straight or curved conveyors as well as methods of driving endless conveyor belts. Pivotable magnets (310...) can be free floating in holders (330), or in other embodiments, each pivotable magnet (50...,190...,350...) can be interconnected serially with its previous and its subsequent magnet. Whether free floating or serially interconnected pivotable magnets (50...,190...,310...,350...) create the virtual continuous magnetic body (150...,290...,440...). When the virtual continuous magnetic body (150...,290...,440...) encounters the stator's electromagnetic field the resultant magnetic flux pushes the continuous magnetic body (150...,290...,440...) through the groove (40, 210, 230) of the conveyor bed (38, 112, 220). Each of the pivotable magnets (50...,190...,310...,350...) is dimensioned to not impede its previous magnet and its subsequent magnet, when the electromagnetic flux is reversed.
摘要翻译：直线或弯曲输送机的感应驱动装置以及驱动无端传送带的方法。可枢转磁体（310 ...）可以自由浮动在支架（330）中，或在其他实施例中，每个可枢转磁体（50 ...，190 ...，350 ...）可以与其先前的和其随后的磁铁。自由浮动或串联互连的可枢转磁铁（50 ...，190 ...，310 ...，350 ...）是否产生虚拟连续磁体（150 ...，290 ...，440 ... ）。当虚拟连续磁体（150 ...，290 ...，440 ...）遇到定子的电磁场时，所得磁通量推动连续磁体（150 ...，290 ...，440 .. ）通过输送床（38,112,220）的凹槽（40,210,230）。当电磁通量反转时，每个可枢转磁体（50 ...，190 ...，310 ...，350 ...）的尺寸被设计成不妨碍其先前的磁体及其随后的磁体。

6. 发明申请

WO2003031288A3 INDUCTION DRIVE FOR INDUCTION DRIVEN CONVEYOR 审中-公开
公开(公告)号：WO2003031288A3
公开(公告)日：2003-04-17
申请号：PCT/US2002/030225
申请日：2002-09-24
申请人： LEE, Rick
发明人： LEE, Rick
IPC分类号： B65G15/06
摘要： Induction drives for either straight or curved conveyors as well as methods of driving endless conveyor belts. Pivotable magnets (310...) can be free floating in holders (330), or in other embodiments, each pivotable magnet (50...,190...,350...) can be interconnected serially with its previous and its subsequent magnet. Whether free floating or serially interconnected pivotable magnets (50...,190...,310...,350...) create the virtual continuous magnetic body (150...,290...,440...). When the virtual continuous magnetic body (150...,290...,440...) encounters the stator's electromagnetic field the resultant magnetic flux pushes the continuous magnetic body (150...,290...,440...) through the groove (40, 210, 230) of the conveyor bed (38, 112, 220). Each of the pivotable magnets (50...,190...,310...,350...) is dimensioned to not impede its previous magnet and its subsequent magnet, when the electromagnetic flux is reversed.

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