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1. 发明申请

WO1994001534A1 HEMATOPOIETIC FACILITATORY CELLS AND THEIR USES 审中-公开
标题翻译： HEMATOPOIETIC FACINAITORY细胞及其用途
公开(公告)号：WO1994001534A1
公开(公告)日：1994-01-20
申请号：PCT/US1993006506
申请日：1993-07-09
申请人： THE UNIVERSITY OF PITTSBURGH
发明人： THE UNIVERSITY OF PITTSBURGH , ILDSTAD, Suzanne, T. , SIMMONS, Richard, L. , RICORDI, Camillo , WREN, Sherry, M. , KAUFMAN, Christina
IPC分类号： C12N05/00
CPC分类号： C12N5/0634 , A61K35/28 , A61K2035/122 , A61K2035/124
摘要： The present invention relates to mammalian hematopoietic facilitatory cells (FC). In particular, it relates to the isolation, characterization and uses of the FC. The FC of the present invention can be distinguished from all other known bone marrow cells by their morphology, cell surface phenotype and (in vivo) function. It has now been established that purified hematopoietic stem cells alone or bone marrow cells depleted of FC do not readily engraft in a recipient. When co-administered with other bone marrow cells, especially the hematopoietic stem cells into a recipient, the FC enhance their engraftment, without apparent adverse biologic activities. In fact, the ability of the FC to enhance the engraftment of bone marrow cells in establishing lymphohematopoietic chimerism without producing graft versus host disease also induces donor-specific tolerance to permit the permanent acceptance of donor's cells, tissues and organs. Therefore, FC may have a wide range of applications, including, but not limited to, hematopoietic reconstitution by bone marrow transplantation for the treatment of cancers, anemias, autoimmunity, immunodeficiency, viral infections and metabolic disorders as well as facilitation of solid organ, tissue and cellular transplantation.
摘要翻译：本发明涉及哺乳动物造血辅助细胞（FC）。特别地，它涉及FC的隔离，表征和使用。本发明的FC可以通过其形态，细胞表面表型和（体内）功能与所有其他已知的骨髓细胞区分开来。现在已经确定，单独的纯化的造血干细胞或FC耗尽的骨髓细胞不容易在接受者中移植。当与其他骨髓细胞，特别是造血干细胞共同施用到受体中时，FC增强其植入，而没有明显的不利生物活性。事实上，FC增强骨髓细胞植入建立淋巴造血嵌合体而不产生移植物抗宿主病的能力也会诱发供体特异性耐受，从而允许永久接受供者的细胞，组织和器官。因此，FC可能具有广泛的应用，包括但不限于骨髓移植造血重建用于治疗癌症，贫血，自身免疫，免疫缺陷，病毒感染和代谢紊乱以及促进实体器官，组织和细胞移植。

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