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1. 发明申请

WO2018178722A1 PRODRUG COMPOSITIONS 审中-公开
公开(公告)号：WO2018178722A1
公开(公告)日：2018-10-04
申请号：PCT/GB2018/050888
申请日：2018-03-29
申请人： THE UNIVERSITY OF LIVERPOOL , THE JOHNS HOPKINS UNIVERSITY
发明人： RANNARD, Steven Paul , OWEN, Andrew , CURLEY, Paul , HOBSON, James , SICCARDI, Marco , FREEL MEYERS, Caren L. , AL-KHOUJA, Amer , MEYERS, David J. , FLEXNER, Charles Williams
IPC分类号： C07F9/6561 , A61K31/513 , A61K31/675 , C07D411/04 , A61P35/00 , A61P31/18 , A61K9/00 , A61K47/00 , A61K9/51
摘要： The present invention provides a composition comprising nanoparticles of prodrugs of certain pharmaceutically active agents, wherein the nanoparticles of prodrugs are dispersed within a carrier material. The present invention further provides processes for the making of the same.

2. 发明申请

WO2023067350A1 SOLID COMPOSITIONS COMPRISING TENOFOVIR ALAFENAMIDE AND/OR BICTEGRAVIR 审中-公开
公开(公告)号：WO2023067350A1
公开(公告)日：2023-04-27
申请号：PCT/GB2022/052684
申请日：2022-10-20
申请人： THE UNIVERSITY OF LIVERPOOL
发明人： RANNARD, Steven Paul , OWEN, Andrew , HOBSON, James , SAVAGE, Alison , BARLOW, Eleanor , CURLEY, Paul , SHARP, Joanne , DONNELLY, Ryan , ZHANG, Chunyang , WU, Yu
IPC分类号： A61K9/00 , A61K9/16 , A61K31/00 , A61P31/00
摘要： The present invention relates to solid compositions comprising microparticles of tenofovir alafenamide and/or bictegravir dispersed within a matrix comprising a first excipient and a second excipient. The present invention also relates to microneedle arrays, implantable rods, aqueous dispersions, and pharmaceutical compositions derived from said solid compositions and uses for the same.

3. 发明申请

WO2022101623A1 PHARMACEUTICALLY ACTIVE COMPOUND FORMULATIONS 审中-公开
公开(公告)号：WO2022101623A1
公开(公告)日：2022-05-19
申请号：PCT/GB2021/052909
申请日：2021-11-10
申请人： THE UNIVERSITY OF LIVERPOOL
发明人： RANNARD, Steven Paul , OWEN, Andrew , HOBSON, James , SAVAGE, Alison , DWYER, Andrew , UNSWORTH, Catherine , MCDONALD, Thomas Oliver
IPC分类号： A61K9/14 , A61K9/16
摘要： The present invention relates to solid compositions of pharmaceutically active compounds, aqueous dispersions derived from these compositions and processes for the preparation of these solid compositions and dispersions. The present invention also relates to pharmaceutical compositions derived from these solid compositions and dispersions, and their use in the treatment and/or prophylaxis of helminthic, protozoal, and viral infections.

4. 发明申请

WO2018178721A1 METHOD FOR PRODUCING A LIQUID COMPOSITION 审中-公开
公开(公告)号：WO2018178721A1
公开(公告)日：2018-10-04
申请号：PCT/GB2018/050887
申请日：2018-03-29
申请人： THE UNIVERSITY OF LIVERPOOL , THE JOHNS HOPKINS UNIVERSITY
发明人： RANNARD, Steven Paul , OWEN, Andrew , CURLEY, Paul , HOBSON, James , SICCARDI, Marco , FREEL MEYERS, Caren L. , AL-KHOUJA, Amer , MEYERS, David J. , FLEXNER, Charles Williams
IPC分类号： A61K9/00 , A61K47/14 , A61K9/08 , A61K47/44 , A61K9/14 , A61K9/19 , A61K9/48 , A61K31/675
摘要： A first aspect of the present invention provides a method of producing a liquid composition comprising stabilised particles of active species in oil by precipitating a solution of the active species in a non-solvent in the presence of one or more stabilisers, mixing the precipitate suspension with an oil and then removing the solvents. Further aspects of the present invention relate to liquid compositions produced by said method and methods of use of such liquid compositions.

5. 发明申请

WO2016124925A1 NANOEMULSIONS 审中-公开
标题翻译：纳米乳液
公开(公告)号：WO2016124925A1
公开(公告)日：2016-08-11
申请号：PCT/GB2016/050252
申请日：2016-02-03
申请人： THE UNIVERSITY OF LIVERPOOL
发明人： RANNARD, Steve , OWEN, Andrew , HOBSON, James , LIPTROTT, Neill , CHAMBON, Pierre
IPC分类号： A61K9/107 , A61K47/10 , A61K47/34 , C08F220/20
CPC分类号： A61K9/1641 , A61K9/0053 , A61K9/107 , A61K9/1075 , A61K31/513 , A61K31/536 , A61K47/10 , A61K47/34 , B01F17/0028 , C08F220/28 , C08F2220/286 , C08F2438/01 , C08F2222/1013
摘要： An oil-in-water emulsion comprises an emulsifier which is a non-gelled branched polymer (e.g. a branched vinyl polymer), wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. This is useful in, for example, facilitating the carrying of hydrophobic materials within aqueous systems, to enhance oral drug delivery. The oil-in-water emulsion may be prepared by mixing an oil phase with an aqueous phase in the presence of an emulsifier, wherein said emulsifier is a non-gelled branched polymer, wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. The oil phase may comprise a further solvent which is miscible with the oil, said solvent being allowed to evaporate to produce the final emulsion.
摘要翻译：水包油乳液包括乳化剂，其是非胶凝的支化聚合物（例如支链乙烯基聚合物），其中所述聚合物的至少一些链的末端终止于5个或更多个碳原子的烷基链，并且其中所述水包油乳液采用z平均直径不大于约1000nm的颗粒的形式。这在例如促进含水系统中的疏水性材料的携带以增强口服药物递送方面是有用的。水包油乳液可以通过在乳化剂存在下将油相与水相混合来制备，其中所述乳化剂是非胶凝的支化聚合物，其中所述聚合物的至少一些链的末端终止于5个或更多个碳原子的烷基链，并且其中水包油乳液采用z平均直径不大于约1000nm的颗粒的形式。油相可以包含与油混溶的另外的溶剂，允许所述溶剂蒸发以产生最终乳液。

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