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1. 发明申请

WO2014086285A1 ANTIFUNGAL COMPOUND AND USES THEREOF 审中-公开
标题翻译：抗真菌化合物及其用途
公开(公告)号：WO2014086285A1
公开(公告)日：2014-06-12
申请号：PCT/CN2013/088483
申请日：2013-12-04
申请人： THE UNIVERSITY OF HONG KONG
发明人： SENEVIRATNE, Chaminda Jayampath , KAO, Yi Tsun Richard , SAMARANAYAKE, Lakshman Perera , YUEN, Kwok Yung , YANG, Dan , WANG, Yu , WONG, Sze Wah, Sarah
IPC分类号： C07D309/34 , A61K31/351 , A61P31/10 , A61P31/18
CPC分类号： A61K31/351 , A01N43/40 , A01N59/00 , A61K9/0019 , A61K9/08 , A01N25/34
摘要： Disclosed herein is a novel antifungal compound, derivatives that are used b treat fungal infections. In a specific embodiment, the compound is a small molecule. In a specific embodiment, the compound described herein inhibits yeast to hypha transition under robust hyphal inducing conditions at lower concentration of the molecule. Also disclosed is a composition comprising the antifungal compound. In a specific embodiment, the composition is a pharmaceutical composition Also disclosed is a method of treating and/or preventing fungal infection using the disclosed compound. The disclosed compound exhibits antifungal activity against wide range of fungal species at slightly higher concentrations. Antifungal compound disclose d herein is use d as anti-biofilm agent against fungal infections. In a specific embodiment, the disclosed compound is effective for systemic fungal infections. In a certain embodiment, the disclosed compound is a broad-spectrum antifungal agent for treating topical local and/or systemic fungal infections. In a specific embodiment, the disclosed compound is used in the prevention or treatment of mycotic infections caused by various fungal pathogens.
摘要翻译：本文公开了一种新型抗真菌化合物，其用于治疗真菌感染的衍生物。在一个具体实施方案中，化合物是小分子。在一个具体的实施方案中，本文所述的化合物在分子浓度较低的条件下，在稳定的菌丝诱导条件下抑制酵母进行菌丝体转化。还公开了包含抗真菌化合物的组合物。在具体实施方案中，组合物是药物组合物。还公开了使用所公开的化合物治疗和/或预防真菌感染的方法。所公开的化合物在稍高的浓度下对广泛的真菌种类显示出抗真菌活性。本文中公开的抗真菌化合物d是使用d作为抗真菌感染的抗生物膜剂。在一个具体实施方案中，所公开的化合物对全身真菌感染是有效的。在某个实施方案中，所公开的化合物是用于治疗局部局部和/或系统性真菌感染的广谱抗真菌剂。在具体实施方案中，所公开的化合物用于预防或治疗由各种真菌病原体引起的霉菌感染。

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