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1. 发明申请

WO2010019712A1 MODULATION OF INFLUENZA VIRUS 审中-公开
标题翻译：流感病毒调控
公开(公告)号：WO2010019712A1
公开(公告)日：2010-02-18
申请号：PCT/US2009/053612
申请日：2009-08-12
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , DEGRADO, William, F. , STOUFFER, Amanda, L. , ACHARYA, Rudresh , SALOM-ARBONA, David , POLISHCHUK, Alexei
发明人： DEGRADO, William, F. , STOUFFER, Amanda, L. , ACHARYA, Rudresh , SALOM-ARBONA, David , POLISHCHUK, Alexei
IPC分类号： C40B30/02
CPC分类号： G06F19/706 , G06F19/16
摘要： The present invention provides, among other things, methods for the identification of compounds that are capable of modulating the activity of the influenza A virus. For example, the present methods provide platforms for identifying small molecule inhibitors that target the proton transport pathway defined at least in part by two or more of the highly conserved channel residues 27, 30, 31, 34, 37, 41, 44, and 45 of the influenza A M2 protein. In one aspect, the present invention is directed to methods comprising comparing spatial models of a plurality of test compounds with the spatial model of the pathway defined by at least two residues from among residues 27, 30, 31, 34, 37 or 41, 44, and 45 on one or more subunits of the M2 transmembrane protein of the influenza A virus to determine the spatial complementarity of each of the test compounds with the pathway; assessing the ability of the test compounds to bind to the pathway; and, based on the assessed ability of the test compounds to bind the pathway, determining the compound that modulates the activity of influenza A.
摘要翻译：本发明尤其提供了用于鉴定能够调节甲型流感病毒活性的化合物的方法。例如，本方法提供用于鉴定靶向至少部分由两个或更多个高度保守通道残基27,30,31,34,37,41,44和45定义的质子转运途径的小分子抑制剂的平台的流感A M2蛋白。在一个方面，本发明涉及包括将多个测试化合物的空间模型与由残基27,30,31,34,37或41,44中的至少两个残基限定的途径的空间模型进行比较的方法和45个在甲型流感病毒的M2跨膜蛋白的一个或多个亚基上，以确定每种测试化合物与途径的空间互补性; 评估测试化合物结合途径的能力; 并且基于测试化合物结合途径的评估能力，确定调节流感A的活性的化合物。

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